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Interleukin-8 definition: A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.
interleukin 8 definition: basic, heparin-binding, proinflammatory cytokine produced by monocytes, vascular endothelium, and other cell types; acts on neutrophils as a chemoattractant, activator, and modulator of endothelial adhesion and transmigration.
Interleukin-8 definition: A member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types including monocytes, macrophages, T-lymphocytes, fibroblasts, endothelial cells, and keratinocytes. It functions as a chemoattractant, and is also a potent angiogenic factor. (from LocusLink)
Chemokine CCL2 definition: A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. It is produced by LEUKOCYTES of both monocyte and lymphocyte lineage and by FIBROBLASTS during tissue injury. It has specificity for CCR2 RECEPTORS.
monocyte chemoattractant protein 1 definition: attracts monocytes and memory T lymphocytes to the exclusion of other leukocytes such as neutrophils; it has been hypothesized that it plays a pathogenic role in a variety of diseases having a monocyte inflammatory component, such as atherosclerosis.
Small Inducible Cytokine A2 definition: A chemokine that is a chemoattractant for human monocytes and may also cause cellular activation of specific functions related to host defense. It is produced by leukocytes of both monocyte and lymphocyte lineage and by fibroblasts during tissue injury. (MeSH Definition)
Small Inducible Cytokine A2 definition: This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. (from LocusLink)
Chemokines, CC definition: Group of chemokines with adjacent cysteines that are chemoattractants for lymphocytes, monocytes, eosinophils, basophils but not neutrophils.
Beta Chemokine definition: Encoded by CC Cytokine Genes, Beta Chemokines are CC-type dual-cysteine chemokines with adjacent cysteine residues in their primary sequence that act as chemoattractants for lymphocytes, monocytes, eosinophils, and basophils, but not for neutrophils. (NCI)
Chemokines, CXC definition: Group of chemokines with paired cysteines separated by a different amino acid. CXC chemokines are chemoattractants for neutrophils but not monocytes.
Alpha Chemokine definition: Members of the Alpha-Chemokines are referred to also as the 4q chemokine family because the genes encoding members of this family map to human chromosome 4q12-21. The first two cysteine residues of members of this family are separated by a single amino acids and these proteins, therefore, are called also CXC-Chemokines. Some members of the subgroup of the human CXC-Chemokines are defined by the conserved ELR sequence motif (glutamic acid-leucine-arginine) immediately preceding the first cysteine residue near the amino-terminal end. Chemokines with an ELR sequence motif have been found to chemoattract and activate primarily neutrophils. Chemokines without the ELR sequence motif appear to chemoattract and activate monocytes, dendritic cells, T-cells, NK-cells, B-lymphocytes, basophils, and eosinophils.
Chemokines definition: Class of pro-inflammatory cytokines that have the ability to attract and activate leukocytes. They can be divided into at least three structural branches: C; (CHEMOKINES, C); CC; (CHEMOKINES, CC); and CXC; (CHEMOKINES, CXC); according to variations in a shared cysteine motif.
chemokine definition: family of 8-10 KD cytokines; chemoattract leukocytes.
Chemokine definition: Chemokines, short for chemotactic cytokines, are a complex superfamily of small, secreted proteins (6-14 kD) that were originally characterized by their effects on a variety of leukocytes. Usually chemokines act on more than one leukocyte, and a leukocyte can express more than one type of receptor. To date there are at least 40 known chemokines and at least 16 known receptors, and this number seems to increase daily.
Chemokine definition: Chemokines constitute a superfamily of small (8-10 kDa), inducible, secreted, pro-inflammatory cytokines that are involved in a variety of immune and inflammatory responses as well as in viral infection. Chemokines act primarily as chemoattractants and activators of specific types of leukocytes. Some members of this family were initially identified on the basis of their biological activities (e.g., IL-8, GRO), others were discovered using subtractive hybridization (e.g., RANTES) or signal sequence trap (e.g., PBSF/SDF-1)11 cloning strategies. They attract and activate leukocytes and regulate diverse cellular systems and organs ranging from blood vessels to the central nervous system.
Chemokines, C definition: Group of chemokines without adjacent cysteines that are chemoattractants for lymphocytes only.
Gamma Chemokine definition: Gamma chemokines are cytokines that lack adjacent cysteine residues and act as chemoattractants for lymphocytes. Most members of the chemokind family have at least four conserved cysteine residues that form two intramolecular disulfide bonds.
Chemokines, CX3C definition: Group of chemokines with the first two cysteines separated by three amino acids. CX3C chemokines are chemotactic for natural killer cells, monocytes, and activated T-cells.
Delta Chemokine definition: The last family member of chemokines is the CX3C (delta) chemokines. As the acronym suggests, there are three amino acids between the N-terminal cysteine residues.
Other Recombinant Chemokine definition: Formulated therapeutic analogs of one of a number of endogenous chemokines other than those classified as CXC, CC, C, or CX3C (previously known as alpha, beta, gamma, and delta, respectively). (NCI04)
Recombinant Beta Chemokine definition: Formulated therapeutic analogs of one of a number of endogenous chemotactic polypeptide cytokines. Beta chemokine is synthesized and released by macrophages, endothelial cells, keratinocytes, fibroblasts, and smooth muscle cells in response to infection or tissue damage, recruiting circulating macrophages to sites of production. This agent may regulate tumor growth by modulating tumor-associated angiogenesis and metastasis and may either promote or inhibit tumor growth. (NCI04)
Recombinant Alpha Chemokine definition: One of a number of chemotactic cytokines. Alpha chemokines are small polypeptides released by macrophages, endothelial cells, keratinocytes, fibroblasts, and smooth muscle cells in the presence of infection or physical tissue damage. In a therapeutic setting, these agents may act as chemoattractants to recruit neutrophils and T cells from the blood to sites of infection or damage and may either promote or inhibit tumor growth by modulating tumor-associated angiogenesis and metastasis. Also known as CXC chemokines. (NCI04)
Recombinant Chemokine definition: Formulated therapeutic analogs of one of a number of endogenous small polypeptide cytokines with potential antineoplastic activity. Synthesized by macrophages, endothelial cells, keratinocytes, fibroblasts, and smooth muscle cells, chemokines are released in the presence of infection or physical tissue damage, and act as chemoattractants to recruit macrophages, neutrophils, and T cells from the blood to sites of infection or damage. These agents may regulate tumor growth by modulating tumor-associated angiogenesis and metastasis and can either promote or retard tumor growth. (NCI04)
Recombinant Gamma Chemokine definition: A family of synthetic or recombinant C-type chemokines lacking adjacent cysteine residues and act as chemoattractants for lymphocytes.
Recombinant Delta Chemokine definition: Recombinant form of endogenous delta-chemokine family.
DARC Gene definition: This gene is involved in cytokine recognition.
Chemokine CCL1 definition: A CC-type chemokine secreted by activated MONOCYTES and T-LYMPHOCYTES. It has specificity for CCR8 RECEPTORS.