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Eosinophilia definition: Abnormal increase of EOSINOPHILS in the blood, tissues or organs.
eosinophilia definition: disordered formation of eosinophils or an abnormal accumulation or deficiency of these cells.
Eosinophils definition: Granular leukocytes with a nucleus that usually has two lobes connected by a slender thread of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin.
eosinophil definition: granular leukocyte readily stained by eosin; granules are coarse, round, and uniform in size; the nucleus usually has two lobes connected by a slender thread of chromatin; these cells are thought to play a specialized role in immunity to helminth infections.
eosinophil definition: A type of white blood cell.
Eosinophil definition: Granular leukocytes with a nucleus that usually has two lobes connected by a slender thread of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin.
Acute Myeloid Leukemia with Abnormal Marrow Eosinophils definition: An acute myeloid leukemia (AML) with inv(16)(p13q22) or t(16;16)(p13;q22);(CBF-beat/MYH11). This AML shows monocytic and granulocytic differentiation and the presence of a characteristically abnormal eosinophil component in the bone marrow. This type of AML has a favorable prognosis. (WHO, 2001)
Eosinophil Count definition: The determination of the number of eosinophils in a blood sample.
Eosinophils definition: A measurement of the eosinophils per unit of a biological specimen.
Allergy Chemokine Network Pathway definition: The inflammatory response associated with asthma is characterized by the recruitment of eosinophils from the bronchial microcirculation in response to the regulated local production of chemoattractant molecules . Although several chemical mediators are active upon eosinophils in vitro, a central role in eosinophil accumulation in vivo is emerging for the C-C chemokine eotaxin, which was first identified in a guinea pig model of allergic airway inflammation using protein purification and microsequencing . Eotaxin is the dominant eosinophil-selective chemoattractant in this model, acting to cause both local eosinophil recruitment to the lung, and the release of a rapidly mobilizable pool of bone marrow eosinophils in cooperation with IL-5. Eotaxin and eotaxin-2 are potent stimulators of eosinophils, signaling exclusively via high affinity binding to the receptor CCR3. C-C chemokines, including MCP-3, MCP-4, and RANTES, also stimulate eosinophils via CCR3, although they show less leukocyte selectivity as they additionally signal via other chemokine receptors expressed on a range of leukocytes, including lymphocytes and monocytes. CCR3 is expressed in high numbers on eosinophils and is thought to be the major eosinophil chemokine receptor. Blockade of CCR3 in vivo inhibits eosinophil recruitment in response to eotaxin in both the guinea pig and mouse. More recently, CCR3 expression has been demonstrated on basophils and Th2-type T cells, suggesting possible roles for CCR3 in the genesis and maintenance of allergic inflammation. CCR3 is therefore a major target for anti-inflammatory drug development.
CCR3 Signaling Pathway definition: Eosinophils are a key class of leukocytes involved in inflammatory responses, including allergic reactions in skin and airway. The eosinophil response in inflammation is absent in mice lacking CCR3, indicating the key role of this G protein coupled receptor in inflammation and allergic responses. Eotaxin is a chemokine ligand for CCR3 that recruits eosinophils to the site of inflammation and activates them. Other chemokine ligands of CCR3 include eotaxin-2, MCP-3, MCP-4, and RANTES. Multiple signaling pathways activated by CCR3 participate in the inflammatory response of eosinophils. Eotaxin stimulates intracellular calcium release, production of reactive oxygen species, and changes in actin polymerization through a pertussis sensitive pathway. Rho is a G protein that activates ROCK, a protein kinase. Rho and ROCK regulate actin stress fiber formation and are required for eosinophil chemotaxis. Map kinase pathways are also involved in chemotaxis. Another key action of activated eosinophils is the release of reactive oxygen species, causing tissue damage during chronic inflammatory responses. Blocking eosinophil activation and the signaling pathways that lead to chemotaxis, degranulation, and reactive oxygen release may alleviate inflammatory conditions and inflammation-associated tissue damage. (BioCarta)
Eosinophil to Leukocyte Ratio definition: The determination of the ratio of eosinophils compared to leukocytes in a blood sample. The measurement may be expressed as a ratio or percentage.
Eosinophils/Leukocytes definition: A relative measurement (ratio or percentage) of the eosinophils to leukocytes in a biological specimen.