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Transcription Factor ETV6 definition: TEL protein is a member of the ETS family of transcription factors. It has an HLH motif and an ETS DNA-binding domain. Translocations of the gene produce chimeric proteins in many leukemias of myeloid or lymphoid origins. Leukemogenic translocations often fuse the TEL HLH domain with the tyrosine kinase domain of other genes, such as PDGFRB, NTRK3, and ABL2 or with other transcription factors, such as AML1 and ARNT. (from OMIM 600618 and NCI)
ETV6 Gene definition: This gene plays a regulatory role in transcription and in matrix metalloproteinase activity.
ETV6 wt Allele definition: Human ETV6 wild-type allele is located in the vicinity of 12p13 and is approximately 246 kb in length. This allele, which encodes transcription factor ETV6 protein, is involved in the repression of transcription by RNA polymerase II. Several malignancies, particularly leukemias, are linked to chromosomal translocations of this gene.