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Hypoxia-Inducible Factor 1, Alpha Subunit definition: Under normoxic conditions, HIF-1alpha is rapidly degraded, whereas hypoxia, CoCl(2), or desferroxamine promote protein stabilization, thus evoking its transcriptional activity.
Hypoxia-Inducible Factor 1, alpha Subunit definition: Hypoxia-inducible factor 1, alpha subunit is a basic helix-loop-helix transcription factor that is regulated by OXYGEN availability and is targeted for degradation by VHL TUMOR SUPPRESSOR PROTEIN.
HIF1A Gene definition: This gene plays a role in cardiovascular development and systemic oxygen homeostasis.
HIF1A wt Allele definition: Human HIF1A wild-type allele is located within 14q21-q24 and is approximately 53 kb in length. This allele, which encodes hypoxia-inducible factor 1 alpha protein, is involved in angiogenesis and transcriptional regulation during the cellular adaptive response to hypoxia. Overexpression of the HIF1A gene is associated with several types of cancer such as hepatocellular carcinoma and renal cell carcinoma.