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immunoglobulin E definition: found on the surface membrane of basophils and mast cells in all individuals; may play a role in active immunity to helminthic parasites but in developed countries it is more commonly associated with immediate hypersensitivity diseases such as asthma and hay fever.
Immunoglobulin E definition: An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).
IgE definition: An immunoglobulin isotype (subclass). This isotype has the unique ability to bind with high affinity to IgE receptors (FceRI) on mast cells and basophils and induce degranulation and cytokine production by these cells when they are crosslinked by antigen. In addition to a central role in atopy and allergic responses, it has been speculated that IgE-mediated mast cell degranulation, by its release of mediators that increase vascular permeability, has an important role in the initiation of immune response in general.
Receptors, IgE definition: Specific molecular sites on the surface of B- and T-lymphocytes which combine with IgEs. Two subclasses exist: low affinity receptors (Fc epsilon RII) and high affinity receptors (Fc epsilon RI).
Olizumab definition: A humanized monoclonal antibody directed against the C-epsilon 3 domain of immunoglobulin E. Olizumab binds to this IgE domain, thereby preventing IgE from binding to its high-affinity mast-cell receptor. (NCI04)
IgE binding definition: Interacting selectively with an immunoglobulin of the IgE isotype. [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
Verb definition: [1] Wortart, mit der eine Handlung (z.B. spielen, lachen, werfen), ein Zustand (glänzen, sich auflösen) oder ein Geschehen (regnen, schneien) ausgedrückt wird.
ige definition: gencive.