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Definition
 
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MOS Gene definition: This gene is involved in signal transduction and the control of meioses.
MYB Gene definition: This gene plays a role in hematopoietic cell proliferation and development.
Oncogene MYB definition: Human Oncogene MYB is a mutated variant of MYB Gene, which encodes 6 alternative isoforms of 640 aa 72-kDa nuclear c-MYB protein, a DNA-binding transcriptional activator critical for hematopoietic progenitor cell proliferation and differentiation. MYB contains 3 N-terminal MYB-like DNA-binding domains that specifically recognize YAAC[GT]G, a central transcriptional activation domain and a C-terminal transcriptional repression domain. MYB may interact with HIPK2 and NLK; phosphorylation by NLK on multiple sites may induce proteasomal degradation. Ubiquitination may be mediated by SIAH1. Oncogene MYB disrupts normal cell function.
Oncogenes definition: Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of "v-" before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix "c-" before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene.
oncogene definition: endogenous or acquired genes whose presence or activation leads to neoplastic transformation; compare with TUMOR SUPPRESSOR GENE and PROTOONCOGENE.
oncogene definition: A gene that normally directs cell growth. If altered, an oncogene can promote or allow the uncontrolled growth of cancer. Alterations can be inherited or caused by an environmental exposure to carcinogens.
Oncogene definition: A gene that normally directs cell growth. If mutated or overexpressed in a dominant fashion, it can release the cell from normal restraints on growth. It alone or in concert with other changes, converts the cell into a tumor cell. Alterations can be inherited or caused by an environmental exposure to carcinogens.
Proto-Oncogenes definition: Normal cellular genes homologous to viral oncogenes. The products of proto-oncogenes are important regulators of biological processes and appear to be involved in the events that serve to maintain the ordered procession through the cell cycle. Proto-oncogenes have names of the form c-onc.
protooncogene definition: normal, nonpathogenic genes which, when mutated or otherwise altered, become oncogenes; many code for growth factors, growth factor receptors, genetic regulatory proteins, or other signal transduction molecules; compare with TUMOR SUPPRESSOR GENE and ONCOGENE.
Proto-Oncogene definition: Oncogenes are altered forms of normal cellular genes called proto-oncogene. Many proto-oncogenes are homologous to viral oncogenes and involved in the control of cell proliferation or differentiation. Mutations, amplifications or rearrangements of proto-oncogenes lead to upregulated or deregulated cell growth and allow them to function as oncogenes.
Genes, Tumor Suppressor definition: Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.
tumor suppressor gene definition: genes whose loss or deactivation leads to neoplastic transformation; compare with ONCOGENE and PROTOONCOGENE.
tumor suppressor gene definition: (TOO-mer) Genes in the body that can suppress or block the development of cancer.
Tumor Suppressor Gene definition: Tumor Suppressor Genes encode proteins whose functions inhibit expression of tumorigenic phenotypes by holding cellular proliferation in check. When inactivated or lost, a barrier to normal proliferation is removed and deregulated growth is possible. (NCI)
Oncogene ABL1 definition: Human v-abl Abelson murine leukemia viral oncogene homolog 1 (ABL1) gene, located at 9q34.1, encodes proto-oncogene tyrosine-protein kinase ABL1 protein. Alternative splicing of this gene produces two protein isoforms. A t(9;22) translocation, resulting in the fusion of the BCR and ABL1 genes, has been detected in many cases of chronic myelogeneous leukemia.. This BCR-ABL fusion gene is also present in acute myeloid leukemia and acute lymphoblastic leukemia.
V-ABL definition: V-ABL is an ABL oncogene of Abelson's murine leukemia virus.
Oncogene MYC definition: A viral and cellular gene. A proto-oncogene, identified in several avian tumors, encoding a nuclear protein with a leucine zipper motif.
MYC Gene definition: This gene plays a role in cell cycle progression and apoptosis. Cytogenetic aberrations in the gene are involved in cellular transformation and are associated with a variety of hematopoietic tumors, leukemias and lymphomas.
FOS Gene definition: This gene plays a role in several cellular processes such as: proliferation, differentiation, and transformation.
Oncogene FOS definition: Retrovirus-associated DNA sequences (fos) originally isolated from the Finkel-Biskis-Jinkins (FBJ-MSV) and Finkel-Biskis-Reilly (FBR-MSV) murine sarcoma viruses. The proto-oncogene c-fos encodes a nuclear protein that dimerizes with Jun via a zipper motif to form the transcription factor AP1 and is involved in growth-related transcriptional control. The insertion of c-fos into FBJ-MSV or FBR-MSV induces osteogenic sarcomas in mice. The human c-fos gene is located at 14q21-3 on the long arm of chromosome 14.
JUN Gene definition: This gene plays a critical role in transcriptional regulation and cellular growth.
Oncogene JUN definition: An oncogene from an avian sarcoma virus. The protein it encodes dimerizes with fos to form the transcription factor AP1.
Genes, erbB-2 definition: The erbB-2 gene is a proto-oncogene that codes for the erbB-2 receptor (RECEPTOR, ERBB-2), a protein with structural features similar to the epidermal growth factor receptor. Its name originates from the viral oncogene homolog (v-erbB) which is a truncated form of the chicken erbB gene found in the avian erythroblastosis virus. Overexpression and amplification of the gene is associated with a significant number of adenocarcinomas. The human c-erbB-2 gene is located at 17q21.2.
ERBB2 Gene definition: This gene plays a role in cellular proliferation and is involved in the oncogenic process through amplification and/or overexpression in several cancers.
Oncogene ErbB2 definition: Human Oncogene ErbB2 is a mutated variant of ERBB2 Gene, which encodes ERRB2 Receptor Protein Tyrosine Kinase, a 185-kDa type I membrane glycoprotein similar to EGFR that controls cell growth. Ligand binding increases ERBB2 tyrosine phosphorylation. A heterodimer with ERBB3 and ERBB4, p185ERBB2 is an essential component of the heregulin/neuregulin receptor. ERBB2 forms an IL6-dependent complex with IL6R gp130, resulting in ERBB2 tyrosine phosphorylation and MAPK activation. Oncogene ERBB2 disrupts normal cell function.
THRA Gene definition: This gene plays a role in receptor signaling and regulation of transcription. It is involved in thyroid hormone binding.
THRB Gene definition: This gene plays a role in receptor signaling and regulation of transcription. It is involved in inner ear development and color vision.
Genes, erbA definition: Genes related to the erbA DNA sequence that was first isolated from the avian erythroblastosis virus (ERYTHROBLASTOSIS VIRUS, AVIAN), v-erbA. In cells, erbA genes encode thyroid hormone receptors (RECEPTORS, THYROID HORMONE). Two distinct c-erbA genes have been identified: erbA-alpha located at 17q21; and erbA-beta located at 3p24. Truncations at the N- and C-terminals of erbA result in products resembling v-erbA. Truncations affect hormone responsiveness but not DNA binding capacity.
Oncogene ERB A definition: Two ERBA proto-oncogenes located on separate chromosomes, encode ERBA alpha and ERBA beta, which are thyroid hormone receptors in the nucleus and bind DNA to activate transcription. Multiple thyroid hormone receptor (THR) genes may be encoded in the human genome and perhaps as many as five loci with varying expression in different tissues and stages of development. The ERBA1 gene at 17q11.2 encodes ERBA alpha-1, ERBA alpha-2, and ERBA alpha-3, each produced by alternative splicing. All ERBA1 transcripts are coordinately expressed. The ERBA2 gene at 3p24.3 encodes ERBA beta-1 and a neighboring gene encodes ERBA beta-2. The TH receptor expressed in the mammalian CNS and most other tissues (except liver) is encoded by ERBA1. The receptor present in liver (the major TH-responsive organ) and some other tissues is encoded by ERBA2. Point mutations in the ERBA2 gene are associated with generalized resistance to thyroid hormone.
ERG Gene definition: This gene plays a regulatory role in transcription, cellular maintenance and hematopoiesis.
ETS1 Gene definition: This gene is involved in transcriptional activation and may play a role in the suppression of tumorigenicity.
ETS2 Gene definition: This gene is involved in transcriptional activation and skeletal development.
Oncogene AP2 definition: Human transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) (TFAP2A) gene, located at 6p24, encodes transcription factor AP-2 alpha. This gene is developmentally regulated and expression is induced by retinoic acid. Alternative splicing of the AP2 gene produces four mRNA transcripts, resulting in four protein isoforms. One of these proteins is a negative regulator of transcriptional activation by AP-2.
MCF2 Gene definition: This gene is involved in signal transduction.
Oncogene DBL definition: Human oncogene DBL is a mutated form of the MCF.2 cell line derived transforming sequence (MCF2) gene, located at Xq27, which encodes 4 alternative variants of the proto-oncogene DBL protein. Activation of the DBL oncogene is generated by 5-prime recombination with chromosome 3pter-p21 and by 3-prime recombination with chromosome 16p13-q22.
NOTCH4 Gene definition: This gene plays a regulatory role in vascular, renal and hepatic development.
EIF3E Gene definition: This gene is involved in the initiation and regulation of protein translation.
AKT1 Gene definition: This gene is involved in signal transduction and negative regulation of apoptosis. It also plays a role in glucose transport, glycogen synthesis, protein synthesis and neuronal survival.
AKT2 Gene definition: This gene plays a role in glucose homeostasis and the inhibition of apoptosis.
WNT1 Gene definition: This gene plays a role in signal transduction and intercellular communication. It is involved in neural development.
AXL Gene definition: This gene plays a role in the tyrosine kinase receptor-mediated signal transduction pathway. The gene is also involved in cellular proliferation and aggregation.
BRAF Gene definition: This gene is involved in cell organization/biogenesis and the inhibition of apoptosis.
CBL Gene definition: This gene plays a role in signal transduction and the regulation of protein degradation.
CRK Gene definition: This gene is involved in cellular signal transduction and plays a role in transformation.
CRKL Gene definition: This gene plays a role in cell communication and signal transduction.
CTTN Gene definition: This gene plays a role in epithelial cytoskeletal organization and in cellular adhesion.
EPHA1 Gene definition: This gene is involved in the mediation of development in the nervous system.
ERBB3 Gene definition: This gene is involved in signal transduction pathways that result in cellular proliferation or differentiation. The gene has also been associated with numerous cancers.
ERBB4 Gene definition: This gene is involved in neuronal development and plays a role in receptor tyrosine kinase signal transduction that regulates cellular proliferation and differentiation.
EVI1 Gene definition: This gene plays a role in transcriptional activation. Retroviral activation of the gene plays an important role in the translocations leading to myeloid leukemia/myelodysplastic syndrome.
MYCN Gene definition: This gene is involved in transcriptional regulation and amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.
Oncogene MYCN definition: Human Oncogene NMYC is a mutated variant of NMYC Gene (MYC Family), which encodes two nuclear N-MYC Proteins from the same mRNA; both are phosphorylated, exceptionally unstable and bind to single- and double-stranded DNA. N-MYC is a likely heterodimeric bZIP transcription factor with MAX; efficient DNA binding requires dimerization with another bHLH protein. NMYC amplification is associated with oncogenic transformation. Oncogene NMYC disrupts normal cell function.
MYCL1 Gene definition: This gene is involved in transcriptional regulation and is frequently amplified in small-cell lung cancer.
Oncogene LMYC definition: Human Oncogene LMYC is a mutated variant of LMYC Gene (MYC Family), which encodes L-MYC Protein, a bZIP transcription factor that binds to DNA as a heterodimer with MAX; DNA binding requires dimerization with another bHLH protein. The gene is amplified 10- to 20-fold in small-cell lung cancer (SCCL). Several LMYC mRNAs are produced in SCCL cells by alternative splicing and alternative polyadenylation. Oncogene LMYC disrupts normal cell function.
FGF3 Gene definition: This gene plays a role in the regulation of cell growth.
FGF6 Gene definition: This gene is involved in angiogenesis and cell proliferation.
FLT1 Gene definition: This gene is involved in cellular proliferation, differentiation and tyrosine kinase signal transduction.
GLI1 Gene definition: This gene plays a regulatory role in transcription and embryonic development.
GLI2 Gene definition: This gene is involved in transcriptional regulation and plays a role in sonic hedgehog signal transduction.
LYN Gene definition: This gene plays a role in signal transduction.
CXCL2 Gene definition: This gene is involved in the regulation of angiogenesis.
CXCL3 Gene definition: This gene plays a role in inflammatory processes and G-protein coupled receptor signaling.
MAS1 Gene definition: This gene plays a role in G protein-coupled receptor signal transduction and cellular proliferation.
Oncogene ETS definition: Oncogene ETS was originally discovered as a chimeric component, along with a truncated v-myb gene, in the genome of E26, an avian leukosis virus. ETS1 encodes 42-52 kD nuclear phosphoprotein transcription factors that interact with purine-rich promoter/enhancer sequences in the TCRA gene. ETS1 also regulates p16(INK4A) gene expression. The human gene is located at 11q23.3.
ABL2 Gene definition: This gene plays a role in signal transduction.
GLI3 Gene definition: This gene plays a regulatory role in limb development and is involved in sonic hedgehog signal transduction.
Oncogene FPS-FES definition: Human Oncogene FPS-FES is a mutated variant of FES Gene (FES/FPS Subfamily), which encodes 822 aa 93-kDa Tyrosine-Protein Kinase FES/FPS, a tyrosine-specific protein kinase involved in normal hematopoiesis and containing an FCH and SH2 domain. The FES chromosomal location is linked to a translocation identified in patients with acute promyelocytic leukemia. A truncated transcript is generated utilizing a start site in a far downstream exon. Oncogene FPS-FES disrupts normal cell function.
CXCL1 Gene definition: This gene is involved in immune processes and has been implicated in cancer metastasis.
ELK1 Gene definition: This gene plays a role in transcriptional regulation and mediates DNA-binding interactions. The gene is also involved in MAP kinase signal transduction.
CSF1R Gene definition: This gene is essential for the regulation of the production, differentiation, and function of macrophages.
Oncogene EGF definition: Human Oncogene EGF is a mutated variant of EGF Gene, which encodes Epidermal Growth Factor, a 53-aa peptide hormone with profound effects on cell differentiation and potent mitogenic effects on a variety of ectodermal and mesodermal cells. The EGF precursor is believed to exist as a membrane-bound molecule that is proteolytically cleaved to generate the hormone. Oncogene EGF disrupts normal cell function.
Oncogene CSF1R definition: Human colony stimulating factor 1 receptor (CSF1R) gene, located at 5q33.2-q33.3, encodes macrophage colony stimulating factor I receptor protein. Mutations in this gene have been detected in both chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. One out of fifty hematologically normal individuals exhibit a CSFR1 variant allele (Y969C) that may cause a predisposition to myeloid malignancy.
FGF4 Gene definition: This gene is involved in development and spermatogenesis.
Oncogene HST definition: Human Oncogene HST is a mutated variant of FGF4 Gene (FGF Family) about 35 kb downstream of INT2 (same orientation), which encodes Fibroblast Growth Factor 4, a heparin-binding growth factor with homology to basic and acidic FGF. Gremlin relays an SHH signal from the polarizing region to the apical ectodermal ridge. Formin-dependent activation of BMP-antagonist Gremlin induces FGF4 and the SHH/FGF4 feedback loop. Oncogene HST disrupts normal cell function.
LCK Gene definition: This gene is involved in signal transduction and the development/function of T cells.
Oncogene LCK definition: Human Oncogene LCK is a mutated variant of LCK Gene, which encodes p56LCK, a lymphocyte-specific tyrosine protein kinase with an SH2 and SH3 domain. LCK may participate in T-cell activation; p56LCK regulates allelic exclusion at the TCR beta locus. It binds to CD4, CD8 and IL-2R beta chain cytoplasmic domains. p56LCK is quickly activated by mIg cross-linking on B-cells or by TCR cross-linking. Pre-TCR co-localizes with p56LCK kinase in membrane rafts resulting in phosphorylation of CD3-epsilon and ZAP70. p56LCK, in the TCR complex, activates DNA binding of STAT5A and STAT5B. Oncogene LCK disrupts normal cell function.
FGR Gene definition: This gene plays a role in the regulation of cell migration and adhesion.
Oncogene FGR definition: Human Oncogene FGR is a mutated variant of FGR Gene (SRC Family), which encodes 529-aa 60-kDa p55-FGR, a protein tyrosine kinase that may bind PTPNS1 and contains 1 SH2 and 1 SH3 domain. Oncogene FGR disrupts normal cell function.
DEK Gene definition: This gene is involved in RNA processing and regulation of chromatin organization.
FOSB Gene definition: This gene plays a role in transcriptional regulation and several critical cellular processes.
RUNX1 Gene definition: This gene plays a role in transcriptional regulation and cytogenetic aberrations are associated with several leukemias.
WNT3 Gene definition: This gene plays a role in signal transduction and intercellular communication. It is involved in neural development.
MAP3K8 Gene definition: This gene is involved in cell growth, survival and proliferation.
EGFR Gene definition: This gene is involved in the epidermal growth factor signal transduction pathway.
FES Gene definition: This gene is involved in hematopoiesis and the maintenance of cellular transformation.
Oncogene KIT definition: Cloned cancer gene for Familial gastrointestinal stromal tumors (GIST), KIT proto-oncogene encodes a putative transmembrane receptor tyrosine kinase for stem cell factor and is critical in the development of pluripotent hematopoietic stem cells, migrating embryonic melanoblasts, and primordial germ cells. The human proto-oncogene is located at 4q12.
LCN2 Gene definition: This gene may play a role in both the transport of hydrophobic molecules and the mediation of inflammation.
Oncogene MET definition: The MET oncogene is derived from a chromosomal rearrangement involving the MET and TPR (translocated promoter region) loci and is a cloned gene for Hereditary Papillary Renal Carcinoma. The MET proto-oncogene encodes hepatocyte growth factor receptor, a disulfide-linked two subunit receptor protein tyrosine kinase. The human gene is located at 7q31.
MET Gene definition: This gene plays a regulatory role in the modulation of cell-surface receptors and hepatocyte growth factor interactions.
Oncogene Activation definition: Oncogene Activation involves a permanent and heritable nucleotide sequence change that alters proto-oncogene function and predisposes or promotes neoplastic cellular transformation.
ARAF Gene definition: This gene plays a role in signal transduction and the cellular response to mitogens.
Oncogene Fusion definition: The GENETIC RECOMBINATION of the parts of two or more GENES, including an ONCOGENE as at least one of the fusion partners. Such gene fusions are often detected in neoplastic cells and are transcribed into ONCOGENE FUSION PROTEINS.
Oncogene H-Ras definition: The oncogene (v-ras-Ha or v-Ha-ras) of Harvey murine sarcoma virus (Ha-MuSV) encodes a transforming protein.
DEK wt Allele definition: Human DEK wild-type allele is located within 6p23 and is approximately 40 kb in length. This allele, which encodes protein DEK, plays a role in both 3' splice site discrimination and intron removal during mRNA formation. Translocation of the DEK gene is associated with acute myeloid leukemia. This gene is overexpressed in certain types of cancer such as bladder cancer, colon cancer, larynx cancer, and melanoma.
Oncogene E1A definition: Viral Oncogene E1A encodes E1A Protein, a regulator of early viral gene transcription. E1A interacts with diverse cellular proteins to override host cell controls of cell cycle, differentiation or apoptosis. E1A reprograms gene expression and other processes, which leads to transformation. E1A interacts with general and specific transcription factors, co-activators and chromatin-modifying enzymes. Targeted proteins include pRbs, p300/CBP, cyclin/Cdk, transcriptional corepressor CtBP, YY1, RACK1 and SWI/SNF complex, as well as cAMP/PKA signal components. E1A N-terminus binds pRb and p300/CBP regulators. E1A C-terminus negatively modulates the N-terminus and interacts with CtBP. By binding COUP-TF repressor and decreasing NF-kB Class I enhancer binding, E1A can repress MHC Class I gene transcription and allow tumor cells to avoid lysis by cytotoxic T lymphocytes. E1A also determines susceptibility to NK cell lysis.
Oncogene E1B definition: Viral Oncogene E1B encodes 55-kDa E1B Protein, a regulator of early and late viral gene expression. E1B is implicated in selective nuclear export of viral late mRNAs and inhibition of export of cellular mRNAs. E1B counters host cell defenses mediated by p53.
ZBTB48 Gene definition: This gene is involved in transcriptional regulation.
Neutrophil Gelatinase-Associated Lipocalin definition: Neutrophil gelatinase-associated lipocalin (198 aa, ~22 kDa) is encoded by the human LCN2 gene. This protein may play a role in both the transport of lipophilic ligands and the regulation of inflammation.
 
 
frFrench
oncogène definition: Gène qui provoque ou favorise l’apparition de tumeurs.