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Plasminogen Activator Inhibitor 2 definition: Member of the serpin family of proteins. It inhibits both the tissue-type and urokinase-type plasminogen activators.
Plasminogen Activator Inhibitor-2 definition: Expressed in keratinocytes, monocytes, macrophages, placenta, and trophoblast by human SERPINB2 Gene (Serpin Family), 415-aa 47-kDa (predicted, unglycosylated) cytoplasmic Plasminogen Activator Inhibitor 2 is a specific inhibitor of urokinase-type plasminogen activator thought to regulate plasminogen activation in the extravascular compartment and to have a possible role in placental maintenance or embryo development. The primary intracellular distribution of SERPINB2 may also indicate a regulatory role in a protease-dependent cellular process such as apoptosis. (NCI)
Plasminogen Activator Inhibitor-2 definition: Plasminogen Activator Inhibitor-2 is a member of the serpin superfamily that inhibits both tissue-type and urokinase-type plasminogen activators. Inhibitors of plasminogen activators classify in four distinct groups: PAI1 type from endothelial cells; PAI2 type from placenta, monocytes, and macrophages; urinary inhibitor; and protease-nexin-I. PAI2 (monocyte Arg-serpin) also belongs to the serine protease subfamily in which target specificity is determined by an Arg residue at its reactive center: Met/Val for elastase, Leu for kinase, and Arg for thrombin. PAI2 may be involved in many processes; its role in placenta, pregnancy plasma, skin, and inflammatory conditions remain to be established. PAI2 is thought to regulate plasminogen activation in extravascular compartments. High levels are found in keratinocytes, monocytes, and the trophoblast. (from OMIM 173390 and NCI)
Urokinase-Type Plasminogen Activator definition: A proteolytic enzyme that converts PLASMINOGEN to FIBRINOLYSIN where the preferential cleavage is between ARGININE and VALINE. It was isolated originally from human URINE, but is found in most tissues of most VERTEBRATES.
Urokinase definition: Encoded by human PLAU Gene (Peptidase S1 Family), 431-aa 48.5-kD single-chain Urokinase precursor contains a kringle and an EGF-like domain. A potent activator of plasminogen to plasmin conversion by Arg-Val cleavage, the two-chain serine protease is composed of disulfide-linked A (18,000 D) and B (33,000 D) chains that arise from precursor Lys(158)-Ile(159) cleavage by plasmin. Urokinase occurs in high and low mass forms, each consisting of A and B chains. The high mass form contains a long A chain; cleavage after residue 155 in the low mass form yields a short A1 chain. Urokinase is immunologically unrelated to TPA. (from LocusLink, Swiss-Prot, OMIM, and NCI)
Receptors, Urokinase Plasminogen Activator definition: An extracellular receptor specific for UROKINASE-TYPE PLASMINOGEN ACTIVATOR. It is attached to the cell membrane via a GLYCOSYLPHOSPHATIDYLINOSITOL LINKAGE and plays a role in the co-localization of urokinase-type plasminogen activator with PLASMINOGEN.
Urokinase Receptor definition: High affinity cellular receptor for urokinase plasminogen activator (uPA). Plays a role in plasminogen activation by facilitating the conversion of uPA to an enzymatically active form anchored to the cell membrane, where plasminogen activation occurs. Affects tissue remodeling (surface proteolysis, cell adhesion, cell migration), and cancer invasion.
Reagents, Hematology, Fibrinolysis, Plasminogen Activator, Urokinase definition: Hematology reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample to determine urokinase, a plasminogen activator. Urokinase is present in urine and in many tissues, including the vascular endothelium and renal cells; it is present in normal plasma in trace amounts.
U-plasminogen activator receptor activity definition: Combining with the urokinase plasminogen activator to initiate a change in cell activity. [GOC:mah, PMID:16456079]
PLAU Gene definition: This gene plays a role in blood coagulation and the regulation of monocyte/macrophage functions.
PLAUR Gene definition: This gene is involved in the activation of cell-surface plasminogen and localized degradation of the underlying extracellular matrix.
SERPINB2 Gene definition: This gene plays a role in the regulation of transcription, cell proliferation and cell differentiation. It is also involved in the inhibition of apoptosis.
urokinase definition: A drug that dissolves blood clots or prevents them from forming.
PLAU wt Allele definition: Human PLAU wild-type allele is located within 10q24 and is approximately 6 kb in length. This allele, which encodes urokinase-type plasminogen activator protein, plays a role in the degradation of the extracellular matrix via activation of plasminogen. Overexpression of the PLAU gene is associated with cancer progression.
PLAUR wt Allele definition: Human PLAUR wild-type allele is located within 19q13 and is approximately 24 kb in length. This allele, which encodes urokinase plasminogen activator surface receptor protein, plays a role in the regulation of both cell-surface plasminogen activation and localized degradation of the extracellular matrix.