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Acids definition: Chemical compounds which yield hydrogen ions or protons when dissolved in water, whose hydrogen can be replaced by metals or basic radicals, or which react with bases to form salts and water (neutralization). An extension of the term includes substances dissolved in media other than water. (Grant & Hackh's Chemical Dictionary, 5th ed)
acid definition: substances whose aqueous solutions are characterized by a sour taste, the ability to turn blue litmus red, and the ability to react with bases and certain metals to form salts; yields hydrogen ions when dissolved in water, acts as a proton donor, and can accept a pair of electrons to form a covalent bond.
Acid definition: A substance that yields hydrogen ions or protons in aqueous solutions; a substance capable of accepting a pair of electrons for the formation of a coordinate covalent bond; a substance whose hydrogen can be replaced by metals or basic radicals, or which react with bases to form salts and water.
Glial Fibrillary Acidic Protein definition: An intermediate filament protein found only in glial cells or cells of glial origin. MW 51,000.
glial fibrillary acidic protein definition: intermediate filament protein found only in glial cells or cells of glial origin.
Glial Fibrillary Acidic Protein definition: Glial fibrillary acidic protein (432 aa, ~50 kDa) is encoded by the human GFAP gene. This protein may be involved in both neuronal maintenance and astrocyte morphology and motility.
Fibroblast Growth Factor 1 definition: A 17-kDa single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. It binds to HEPARIN, which potentiates its biological activity and protects it from proteolysis. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages, and also has chemotactic and mitogenic activities. It was originally named acidic fibroblast growth factor based upon its chemical properties and to distinguish it from basic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 2).
Fibroblast Growth Factor 1 definition: A modifier of endothelial cell migration and proliferation, Fibroblast Growth Factor 1 may be important in neovascularization. Acidic Fibroblast Growth Factor and alpha-ECGF are derived from FGF1 by posttranslational processing. FGF1 causes the foregut endoderm to develop into the liver. The hepatogenic response is restricted to endoderm tissue, which selectively co-expresses FGF receptors 1 and 4. Different FGF signals appear to initiate distinct phases of liver development during mammalian organogenesis. FGF1 binding to FGFR2 is accompanied by binding of a heparin decasaccharide. (from OMIM 131220 and NCI)
Serine Protease Inhibitor, Kazal Type 1 definition: SPINK1 is secreted from pancreatic acinar cells into pancreatic juice and is thought to prevent trypsin-catalyzed premature activation of pancreatic zymogens. It is also found in serum and various normal tissues; SPINK1 is produced by gastrointestinal tract mucosa where it may protect mucosal cells from proteolytic breakdown. (from OMIM 167790 and NCI)
Acidic Glycosphingolipids definition: A subclass of GLYCOSPHINGOLIPIDS containing large polar heads made up of several sugar units. One or more of their terminal sugar units are bound to a negatively charged molecule at pH 7. Members of this class include: GANGLIOSIDES, uronoglycosphingolipids, SULFOGLYCOSPHINGOLIPIDS, phosphoglycosphingolipids, and phosphonoglycosphingolipids.
PHAPI2 Protein definition: Encoded by human oncogene ANP32B Gene, 272-amino acid 31 kD PHAPI2 is similar to PHAPI. (Swiss-Prot, LocusLink, and NCI)
Amino Acids, Acidic definition: Amino acids with side chains that are negatively charged at physiological pH.
Transforming Acidic Coiled-Coil-Containing Protein 1 definition: Encoded by human TACC1 Gene (TACC Family), TACC1 Protein is expressed during early embryogenesis as an 805-amino acid 87.8 kD protein rich in serine, proline, and acidic residues, with a 20-amino acid N-terminus rich in tryptophan, and containing two nuclear localization signals but no DNA- or RNA-binding domains. A 200-residue C-terminus with extensive alpha-helical segments is expected to adopt a coiled-coil structure. Although the nuclear protein is concentrated at centrosomes and interacts with microtubules and tubulin, its function is not yet determined. (from Swiss-Prot, OMIM, and NCI)
Amino Acid Transport Systems, Acidic definition: Amino acid transporter systems capable of transporting acidic amino acids (AMINO ACIDS, ACIDIC).
acidic amino acid transport definition: The directed movement of acidic amino acids, amino acids with a pH below 7, into, out of, within or between cells. [GOC:ai]
Keratins, Type I definition: A keratin subtype that includes keratins that are generally smaller and more acidic that TYPE II KERATINS. Type I keratins combine with type II keratins to form keratin filaments.
Transforming Acidic Coiled-Coil-Containing Protein 2 definition: Cell culture studies demonstrate that TACC2 interacts with GAS41 and the SWI/SNF chromatin remodeling complex. This suggests that defects in TACC2 expression may affect gene regulation, thus contributing to the pathogenesis of some tumors. (from Genomics 2003;81:192-201)
Transforming Acidic Coiled-Coil-Containing Protein 2 definition: Encoded by human TACC2 Gene, Acidic Coiled-Coil Protein 2 (TACC Family) is a 1026-amino acid 112 kD protein containing a coiled-coil region highly related to that of TACC1. Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins. Nuclear TACC2 protein strongly concentrates at centrosomes throughout the cell cycle and interacts with microtubules. It may organize centrosomal microtubules. Acidic coiled-coil protein 2 is a candidate tumor suppressor protein and a biomarker for tumor progression. (from SWISS-PROT, OMIM, and NCI)
acidic epididymal glycoprotein definition: OBSOLETE (was not defined before being made obsolete). [GOC:mah]
type I intermediate filament definition: OBSOLETE. A type of intermediate filament. [ISBN:0716731363, ISBN:0815316194]
GFAP definition: OBSOLETE. Glial fibrillary acidic protein forms filaments in the glial cells that surround neurons and in astrocytes. [ISBN:0716731363]
ANP32B Gene definition: This gene plays a regulatory role in the propagation of pro-apoptotic events.
ANP32C Protein definition: Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. This protein is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, ANP32C protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is divergent between PP32 and ANP32C. (LocusLink)
ANP32C Protein definition: Encoded by human ANP32C Gene, 234-amino acid 27 kD PP32R1 Protein (PP32 Family) shares approximately 90% amino acid sequence identity with tumor suppressor PP32 and PP32R2. PP32 can inhibit several types of cancers, including prostate and breast cancers. PP32R1 and PP32R2 are tumorigenic. Amino acids 150-174 of PP32 are responsible for its tumor suppressor function and are a region of divergence with PP32R1. Alternative use of PP32, PP32R1, and PP32R2 may modulate the oncogenic potential of human prostate cancer. (from SWISS-PROT, OMIM, and NCI)
ANP32D Protein definition: Encoded by human ANP32D Gene, 131-amino acid 14.8 kD PP32R2 Protein (PP32 Family) shares approximately 90% amino acid sequence identity with tumor suppressor PP32 and PP32R1. PP32 can inhibit several types of cancers, including prostate and breast cancers. PP32R2 and PP32R1 are tumorigenic. Amino acids 150-174 of PP32 are responsible for its tumor suppressor function and are a region of divergence with PP32R1. Alternative use of PP32, PP32R1, and PP32R2 may modulate the oncogenic potential of human prostate cancer. PP32R2 is expressed in prostate cancer. (from SWISS-PROT, OMIM, and NCI)
GFAP Gene definition: This gene may be involved in the regulation of astrocyte morphology and function.
Acidic Region definition: Any portion of a protein molecule with a net negative charge.
WAP Domain definition: The WAP (Whey Acidic Protein) Domain contains eight characteristically-spaced cysteine residues involved in disulphide bond formation and occurs in so-called 'four-disulphide core' proteins. The spatial pattern of these conserved domain cysteines suggests that the otherwise variable domain sequences may adopt a similar fold. The overall degree of domain sequence similarity is low; a few Pro and Gly residues are reasonably well conserved, as are polar/acidic residues between Cys3 and Cys4. WAP sequences are found in Whey Acidic Protein; Elafin (a human skin elastase-specific inhibitor); rat WDNM1 Protein (involved in metastatic potential); Kallmann Syndrome Protein; and guinea pig Caltrin-Like Protein II (inhibits calcium transport into spermatozoa). (NCI)
response to acidity definition: A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. [GOC:tb]