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Annexin A5 definition: A protein of the annexin family isolated from human PLACENTA and other tissues. It inhibits cytosolic PHOSPHOLIPASE A2, and displays anticoagulant activity.
Annexin A5 Protein definition: Encoded by human Annexin A5 Gene, Annexin A5 is a 35 kD 320-amino acid monomeric placental protein similar to PP4-X that contains 4 annexin repeats; some may bind calcium and phospholipid. PP4 and PP4-X (Lipocortin family) are similar to lipocortin I and calpactin I. PP4 is also an Annexin family member, Ca(2+)-dependent phospholipid binding proteins located on the plasma membrane cytosolic face. PP4 forms a voltage-dependent membrane Ca(2+) channel; key amino acids act as selectivity filters and voltage sensors, regulating pore permeability to ions. As an anticoagulant protein, PP4 acts as an indirect inhibitor of the blood coagulation cascade thromboplastin-specific complex. PP4 may bind ATRX. (OMIM, Swiss-Prot, and NCI)
Annexins definition: Family of calcium- and phospholipid-binding proteins which are structurally related and exhibit immunological cross-reactivity. Each member contains four homologous 70-kDa repeats. The annexins are differentially distributed in vertebrate tissues (and lower eukaryotes) and appear to be involved in MEMBRANE FUSION and SIGNAL TRANSDUCTION.
annexin definition: family of proteins which bind phospholipids in the presence of calcium, believed to mediate intracellular calcium's role in membrane fusion and related events such as exocytosis; lipocortin and endonexin may also function extracellularly as inhibitors of phospholipase and blood coagulation.
Annexin A6 definition: Protein of the annexin family with a probable role in exocytotic and endocytotic membrane events.
Annexin A1 definition: Protein of the annexin family exhibiting lipid interaction and steroid-inducibility.
Annexin A2 definition: A member of the annexin family that is a substrate for a tyrosine kinase, ONCOGENE PROTEIN PP60(V-SRC). Annexin A2 occurs as a 36-KDa monomer and in a 90-KDa complex containing two subunits of annexin A2 and two subunits of S100 FAMILY PROTEIN P11. The monomeric form of annexin A2 was formerly referred to as calpactin I heavy chain.
Annexin A3 definition: A protein of the annexin family that catalyzes the conversion of 1-D-inositol 1,2-cyclic phosphate and water to 1-D-myo-inositol 1-phosphate.
Annexin A4 definition: Protein of the annexin family originally isolated from the electric organ of the electric ray Torpedo marmorata. It has been found in a wide range of mammalian tissue where it is localized to the apical membrane of polarized EPITHELIAL CELLS.
Annexin A7 definition: An annexin family member that plays a role in MEMBRANE FUSION and signaling via VOLTAGE-DEPENDENT CALCIUM CHANNELS.
Annexin A8 definition: Annexin VIII belongs to the family of Ca (2+) dependent phospholipid binding proteins (annexins), and has a high 56% identity to annexin V (vascular anticoagulant-alpha). It was initially isolated as 2.2 kb vascular anticoagulant-beta transcript from human placenta, a Ca (2+) dependent phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. However, the fact that annexin VIII is neither an extracellular protein nor associated with the cell surface suggests that it may not play a role in blood coagulation in vivo and its physiological role remains unknown. (LocusLink)
ANXA5 Gene definition: This gene is involved in anticoagulation processes and mediates lipid binding.
ANXA8 Gene definition: This gene plays a role in lipid binding regulation and the overexpression of the gene has been isolated in acute myelocytic leukemia.
Annexin A2, P90 Complex definition: A 90-KD complex containing two subunits of Annexin A2 and two subunits of S100 FAMILY PROTEIN P11.
ANXA5 wt Allele definition: Human ANXA5 wild-type allele is located within 4q27 and is approximately 29 kb in length. This allele, which encodes annexin A5 protein, plays a role in cellular signal transduction, inflammation, growth and differentiation.
ANXA8 wt Allele definition: Human ANXA8 wild-type allele is located in the vicinity of 10q11.2 and is approximately 24 kb in length. This allele, which encodes annexin A8 protein, is involved in anticoagulation. Overexpression of this gene has been associated with acute myelocytic leukemia.