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Definition
 
enEnglish
Arginase definition: A ureahydrolase that catalyzes the hydrolysis of arginine or canavanine to yield L-ornithine (ORNITHINE) and urea. Deficiency of this enzyme causes HYPERARGININEMIA. EC 3.5.3.1.
Arginine definition: An essential amino acid that is physiologically active in the L-form.
arginine definition: essential amino acid physiologically active in the L-form.
Arginine definition: An essential amino acid in juvenile humans, Arginine is a complex amino acid, often found at active site in proteins and enzymes due to its amine-containing side chain. Arginine may prevent or treat heart and circulatory diseases, combat fatigue, and stimulate the immune system. It also boosts production of nitric oxide, relaxing blood vessels, and treating angina and other cardiovascular problems. Arginine is also an important intermediate in the urea cycle and in detoxification of nitrogenous wastes. (NCI04)
Arginine definition: Amino acid with side chain -CH2CH2CH2NH-C(NH)NH2.
Arginine Kinase definition: An enzyme that catalyzes the phosphorylation of the guanidine nitrogen of arginine in the presence of ATP and a divalent cation with formation of phosphorylarginine and ADP. EC 2.7.3.3.
arginine vasopressin definition: usual mammalian antidiuretic hormone, it is a cyclic peptide with arginine in position 8 of the chain.
Arginine Vasopressin definition: The predominant form of mammalian antidiuretic hormone. It is a nonapeptide containing an ARGININE at residue 8 and two disulfide-linked cysteines at residues of 1 and 6. Arg-vasopressin is used to treat DIABETES INSIPIDUS or to improve vasomotor tone and BLOOD PRESSURE.
Vasopressin definition: This protein is processed from a precursor protein consisting of arginine vasopressin and two associated proteins, neurophysin II and a glycopeptide, copeptin. Arginine vasopressin is a posterior pituitary hormone which is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin II, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. It has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. This hormone can contract smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. (LocusLink)
Desmopressin definition: A synthetic octapeptide, and an analogue of human hormone arginine vasopressin with antidiuretic and coagulant activities. Desmopressin binds to V2 receptors in renal collecting ducts which leads to exocytosis of von Willebrand factor (VWF) and tissue plasminogen activator (t-PA) from Weibel-Palade bodies, thereby increasing water resorption. This agent also increases nitric oxide (NO) production via activation of endothelial NO synthase, thereby induces afferent arteriolar vasodilation. Furthermore, desmopressin stimulates the release of factor VIII from endothelial cells mediated through V1a receptor, thereby promotes blood coagulation.
Deamino Arginine Vasopressin definition: A synthetic analog of the pituitary hormone, ARGININE VASOPRESSIN. Its action is mediated by the VASOPRESSIN receptor V2. It has prolonged antidiuretic activity, but little pressor effects. It also modulates levels of circulating FACTOR VIII and VON WILLEBRAND FACTOR.
Plasminogen Activator Inhibitor 2 definition: Member of the serpin family of proteins. It inhibits both the tissue-type and urokinase-type plasminogen activators.
Plasminogen Activator Inhibitor-2 definition: Expressed in keratinocytes, monocytes, macrophages, placenta, and trophoblast by human SERPINB2 Gene (Serpin Family), 415-aa 47-kDa (predicted, unglycosylated) cytoplasmic Plasminogen Activator Inhibitor 2 is a specific inhibitor of urokinase-type plasminogen activator thought to regulate plasminogen activation in the extravascular compartment and to have a possible role in placental maintenance or embryo development. The primary intracellular distribution of SERPINB2 may also indicate a regulatory role in a protease-dependent cellular process such as apoptosis. (NCI)
Plasminogen Activator Inhibitor-2 definition: Plasminogen Activator Inhibitor-2 is a member of the serpin superfamily that inhibits both tissue-type and urokinase-type plasminogen activators. Inhibitors of plasminogen activators classify in four distinct groups: PAI1 type from endothelial cells; PAI2 type from placenta, monocytes, and macrophages; urinary inhibitor; and protease-nexin-I. PAI2 (monocyte Arg-serpin) also belongs to the serine protease subfamily in which target specificity is determined by an Arg residue at its reactive center: Met/Val for elastase, Leu for kinase, and Arg for thrombin. PAI2 may be involved in many processes; its role in placenta, pregnancy plasma, skin, and inflammatory conditions remain to be established. PAI2 is thought to regulate plasminogen activation in extravascular compartments. High levels are found in keratinocytes, monocytes, and the trophoblast. (from OMIM 173390 and NCI)
Protein-Arginine N-Methyltransferases definition: Enzymes that catalyze the methylation of arginine residues of proteins to yield N-mono- and N,N-dimethylarginine. This enzyme is found in many organs, primarily brain and spleen.
Vasotocin definition: A nonapeptide that contains the ring of OXYTOCIN and the side chain of ARG-VASOPRESSIN with the latter determining the specific recognition of hormone receptors. Vasotocin is the non-mammalian vasopressin-like hormone or antidiuretic hormone regulating water and salt metabolism.
vasotocin definition: a nonapeptide hormone having both vasopressin- and oxytocin-like activities, occurring in birds, fish, and amphibians.
arginine butyrate definition: A substance that is being studied as a treatment for cancer.
arginine butyrate definition: The butyric acid salt of the amino acid arginine. In EBV-related lymphomas, arginine butyrate induces EBV thymidine kinase transcription and may act synergistically with the antiviral agent ganciclovir to inhibit cell proliferation and decrease cell viability. In addition, the butyrate moiety inhibits histone deacetylase, which results in hyperacetylation of histones H3 and H4. Acetylated histones have a reduced affinity for chromatin; this reduced histone-chromatin affinity may allow chromosomal unfolding, potentially enhancing the expression of genes related to tumor cell growth arrest and apoptosis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42492&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42492&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2570" NCI Thesaurus)
Arginine Butyrate definition: The butyric acid salt of the amino acid arginine. In EBV-related lymphomas, arginine butyrate induces EBV thymidine kinase transcription and may act synergistically with the antiviral agent ganciclovir to inhibit cell proliferation and decrease cell viability. In addition, the butyrate moiety inhibits histone deacetylase, which results in hyperacetylation of histones H3 and H4. Acetylated histones have a reduced affinity for chromatin; this reduced histone-chromatin affinity may allow chromosomal unfolding, potentially enhancing the expression of genes related to tumor cell growth arrest and apoptosis. (NCI04)
Carboxypeptidase U definition: A metallocarboxypeptidase that removes C-terminal lysine and arginine from biologically active peptides and proteins thereby regulating their activity. It is a zinc enzyme with no preference shown for lysine over arginine. Pro-carboxypeptidase U in human plasma is activated by thrombin or plasmin during clotting to form the unstable carboxypeptidase U.
Arginine Hydrochloride definition: The hydrochloride salt form of arginine, an essential amino acid in juvenile humans. Arginine is a complex amino acid, often found at active sites in proteins and enzymes due to its amine-containing side chain. Arginine may prevent or treat heart and circulatory diseases, combat fatigue, and stimulate the immune system. It also boosts production of nitric oxide, relaxing blood vessels, and treating angina and other cardiovascular problems. Arginine is also an important intermediate in the urea cycle and in detoxification of nitrogenous wastes. (NCI04)
arginine biosynthetic process definition: The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. [ChEBI:29016, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
arginine catabolic process definition: The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. [ChEBI:29016, GOC:go_curators]
arginine metabolic process definition: The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. [ChEBI:29016, GOC:go_curators]
peptidyl-arginine methylation, to symmetrical-dimethyl arginine definition: The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N'(omega)-dimethyl-L-arginine. [RESID:AA0067, RESID:AA0069]
peptidyl-arginine methylation, to asymmetrical-dimethyl arginine definition: The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N(omega)-dimethyl-L-arginine. [RESID:AA0068, RESID:AA0069]
AVP Gene definition: This gene is involved in growth factor regulation and vasoconstriction.
Amino-Arginine definition: An amino acid derivative. As an analog of arginine, amino-arginine competes with the normal substrate arginine and binds to the heme of the NOS as a false substrate, thereby inhibiting endothelial and inducible nitric oxide synthases (eNOS / NOS III and iNOS / NOS II). Arginine is the only physiological substrate for NOS which, in eukaryotic cells, generates NO and L-citrulline from L-arginine and molecular oxygen in a five-electron transfer reaction. This clinical use of amino-arginine is limited due to its epileptogenic properties. (NCI04)
peptidyl-arginine hydroxylation to peptidyl-4-hydroxy-L-arginine definition: The hydroxylation of peptidyl-arginine to form peptidyl-4-hydroxy-L-arginine. [RESID:AA0215]
peptidyl-arginine dihydroxylation to peptidyl-3,4-dihydroxy-L-arginine definition: The dihydroxylation of peptidyl-arginine to form peptidyl-3,4-dihydroxy-L-arginine. [PMID:10978343, RESID:AA0369]
Argipressin definition: A synthetic peptide identical to the endogenous nonapeptide hormone with antidiuretic property. Synthesized in the hypothalamus and stored/released from the posterior lobe of the pituitary, argipressin's primary function is regulating extracellular fluid volume. This agent can also act as a vasoconstrictor, increasing blood pressure and systemic vascular resistance.
arginine transport definition: The directed movement of arginine, 2-amino-5-guanidinopentanoic acid, into, out of, within or between cells. [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
arginine binding definition: Interacting selectively with 2-amino-5-(carbamimidamido)pentanoic acid. [ChEBI:29016, GOC:rl]
 
 
deGerman
Arginin definition: [1] Chemie: semiessentielle, proteinogene α-Aminosäure
 
frFrench
arginine definition: Acide aminé aliphatique, diaminé et polaire dont le groupement latéral contient une guanidine.
arginine-vasopressine definition: Variante orthographique de vasopressine.