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Dependovirus definition: A genus of the family PARVOVIRIDAE, subfamily PARVOVIRINAE, which are dependent on a coinfection with helper adenoviruses or herpesviruses for their efficient replication. The type species is Adeno-associated virus 2.
adeno associated virus group definition: replication is dependent on a helper adenovirus; multiplies in cells which support adenovirus replication in many species of host.
Satellite Viruses definition: Defective viruses which can multiply only by association with a helper virus which complements the defective gene. Satellite viruses may be associated with certain plant viruses, animal viruses, or bacteriophages. They differ from satellite RNA; (RNA, SATELLITE) in that satellite viruses encode their own coat protein.
satellite virus definition: RNA molecules that depend on co-infection of a host cell with a helper virus for multiplication; most are associated with plant viruses.
AIDS-Associated Nephropathy definition: Renal syndrome in human immunodeficiency virus-infected patients characterized by nephrotic syndrome, severe proteinuria, focal and segmental glomerulosclerosis with distinctive tubular and interstitial changes, enlarged kidneys, and peculiar tubuloreticular structures. The syndrome is distinct from heroin-associated nephropathy as well as other forms of kidney disease seen in HIV-infected patients.
HIV-Associated Nephropathy definition: Renal syndrome in human immunodeficiency virus-infected patients characterized by nephrotic syndrome, severe proteinuria, focal and segmental glomerulosclerosis with distinctive tubular and interstitial changes, enlarged kidneys, and peculiar tubuloreticular structures. The syndrome is distinct from heroin-associated nephropathy as well as other forms of kidney disease seen in HIV-infected patients.
Lymphoma, AIDS-Related definition: B-cell lymphoid tumors that occur in association with AIDS. Patients often present with an advanced stage of disease and highly malignant subtypes including BURKITT LYMPHOMA; IMMUNOBLASTIC LARGE-CELL LYMPHOMA; PRIMARY EFFUSION LYMPHOMA; and DIFFUSE, LARGE B-CELL, LYMPHOMA. The tumors are often disseminated in unusual extranodal sites and chromosomal abnormalities are frequently present. It is likely that polyclonal B-cell lymphoproliferation in AIDS is a complex result of EBV infection, HIV antigenic stimulation, and T-cell-dependent HIV activation.
AIDS-Related Lymphoma definition: An aggressive lymphoma that develops in HIV-positive patients. There is a significant increase in the incidence of lymphomas associated with the AIDS epidemic in the last two decades. These lymphomas are usually extranodal, most often express a B-cell phenotype and morphologically are classified as Burkitt, diffuse large B-cell, and Hodgkin lymphomas. The prognosis is closely related to the severity of immunodeficiency.
LDL-Receptor Related Protein-Associated Protein definition: A membrane protein found in the rough endoplasm reticulum (ENDOPLASMIC RETICULUM, ROUGH) that binds to LDL-RECEPTOR RELATED PROTEINS. It may function to prevent ligand binding of receptors during protein processing events within endosomal compartments.
AIDS-Related Lymphoblastic Lymphoma definition: A lymphoblastic lymphoma occurring in HIV-positive patients.
HIV Enteropathy definition: A syndrome characterized by chronic, well-established DIARRHEA (greater than one month in duration) without an identified infectious cause after thorough evaluation, in an HIV-positive individual. It is thought to be due to direct or indirect effects of HIV on the enteric mucosa. HIV enteropathy is a diagnosis of exclusion and can be made only after other forms of diarrheal illness have been ruled out. (Harrison's Principles of Internal Medicine, 13th ed, pp1607-8; Haubrich et al., Bockus Gastroenterology, 5th ed, p1155)
Adeno-Associated Virus Type 2 definition: This strain of viridae is a non-pathogenic human parvovirus that is icosahedral, 20-25 nm in diameter, minus sense, and comprised of a 5 kb. single-stranded DNA genome. The virus is generally monomorphic and has been developed as a gene therapy vector for the treatment of numerous diseases. Wild-type AA-2 retains the ability to preferentially integrate its DNA into a 4 kilobase region of human chromosome 19, designated AAVS1, making it an attractive gene therapy vehicle. The virus has demonstrated anti-cancer activity by inducing apoptosis and inhibiting the growth of cancer cells.
Associated definition: Joined in some kind of relationship.
cell surface definition: The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]
Surface of cell definition: Anatomical surface, which is the surface of the plasma membrane.
Surface of cell definition: Anatomical surface, which is the surface of the plasma membrane.
Cell Surface definition: The part of the cell membrane that faces the exterior of the cell.
AIDS Related Immunoblastic Lymphoma definition: A morphologic variant of diffuse large B-cell lymphoma occurring in HIV-positive patients.