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enEnglish
beta-Alanine definition: An amino acid formed in vivo by the degradation of dihydrouracil and carnosine. Since neuronal uptake and neuronal receptor sensitivity to beta-alanine have been demonstrated, the compound may be a false transmitter replacing GAMMA-AMINOBUTYRIC ACID. A rare genetic disorder, hyper-beta-alaninemia, has been reported.
Meglutol definition: An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate limiting enzyme in the biosynthesis of cholesterol.
Aniline Mustard definition: Alkylating anti-neoplastic agent.
aniline mustard definition: An alkylating mustard with antineoplastic activity. Aniline mustard forms covalent linkages with nucleophilic centers, resulting in depurination, base miscoding and strand scission, and crosslinking of DNA strands, all of which contribute to its cytotoxicity. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39146&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39146&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C249" NCI Thesaurus)
Aniline Mustard definition: An alkylating mustard with antineoplastic activity. Aniline mustard forms covalent linkages with nucleophilic centers, resulting in depurination, base miscoding and strand scission, and crosslinking of DNA strands, all of which contribute to its cytotoxicity. (NCI04)
beta 2-Microglobulin definition: An 11-kDa protein associated with the outer membrane of many cells including lymphocytes. It is the small subunit of the MHC class I molecule. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinemia, renal failure, or kidney transplants.
Beta-2-Microglobulin Protein definition: Beta-2-microglobulin protein (119 aa, ~14 kDa) is encoded by the human B2M gene. This protein plays a role in immune responses and is a key component of major histocompatibility complex class I molecules. The protein is localized to the surface of cells and is utilized as a prognostic marker in persons with cancers that involve white blood cells. The polypeptide is also used as a marker in kidney damage diagnosis and in the detection of viral infection.
Carnosine definition: A naturally occurring dipeptide neuropeptide found in muscles.
beta-N-Acetylglucosaminylglycopeptide beta-1,4-Galactosyltransferase definition: An enzyme that catalyzes the transfer of galactose from UDP-galactose to a specific glycoprotein receptor, 2-acetamido-2-deoxy-D-glucosyl-glycopeptide, during glycopeptide synthesis. EC 2.4.1.38.
Penicillamine definition: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine definition: beta dimethyl analog of cysteine; USP lists as a chelating agent.
penicillamine definition: A drug that removes copper from the body and is used to treat diseases in which there is an excess of this metal. It is also being studied as a possible angiogenesis inhibitor in brain tumors.
penicillamine definition: A beta dimethyl analog of the amino acid cysteine. As a degradation product of penicillin antibiotics, penicillamine chelates with heavy metals and increases their urinary excretion. Possessing antineoplastic properties, penicillamine induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42546&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42546&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C729" NCI Thesaurus)
Penicillamine definition: A beta dimethyl analog of the amino acid cysteine. As a degradation product of penicillin antibiotics, penicillamine chelates with heavy metals and increases their urinary excretion. Possessing antineoplastic properties, penicillamine induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. (NCI04)
Vidarabine definition: A nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the VACCINIA VIRUS and varicella zoster virus.
vidarabine definition: A nucleoside antibiotic isolated from the bacterium Streptomyces antibioticus with antineoplastic activity. Vidarabine inhibits DNA polymerase, resulting in the inhibition of DNA replication in tumor cells. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39150&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39150&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C929" NCI Thesaurus)
Vidarabine definition: A nucleoside antibiotic isolated from the bacterium Streptomyces antibioticus with antineoplastic activity. Vidarabine inhibits DNA polymerase, resulting in the inhibition of DNA replication in tumor cells. (NCI04)
beta carotene definition: A vitamin A precursor. Beta carotene belongs to the family of fat-soluble vitamins called carotenoids.
Beta-carotene definition: Carotenoid consisting of a cyclic structure on each end with additional double bonds at the number 5 and 5' carbon atoms of the cyclic structures.
beta Carotene definition: A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
beta carotene definition: A naturally-occurring retinol (vitamin A) precursor obtained from certain fruits and vegetables with potential antineoplastic and chemopreventive activities. As an anti-oxidant, beta carotene inhibits free-radical damage to DNA. This agent also induces cell differentiation and apoptosis of some tumor cell types, particularly in early stages of tumorigenesis, and enhances immune system activity by stimulating the release of natural killer cells, lymphocytes, and monocytes. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40992&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40992&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1016" NCI Thesaurus)
Beta Carotene definition: A naturally-occurring retinol (vitamin A) precursor obtained from certain fruits and vegetables with potential antineoplastic and chemopreventive activities. As an anti-oxidant, beta carotene inhibits free-radical damage to DNA. This agent also induces cell differentiation and apoptosis of some tumor cell types, particularly in early stages of tumorigenesis, and enhances immune system activity by stimulating the release of natural killer cells, lymphocytes, and monocytes. (NCI04)
beta-Carotene 15,15'-Monooxygenase definition: A monooxygenase that catalyzes the conversion of BETA-CAROTENE into two molecules of RETINAL. It was formerly characterized as EC 1.13.11.21 and EC 1.18.3.1.
pyrazofurin definition: A nucleoside analog. Pyrazofurin potently inhibits orotidine 5'-monophosphate (OMP) decarboxylase, thereby interfering with de novo synthesis of uridine nucleotides and resulting in cytotoxicity. This agent also causes a rapid depletion of the pyrimidine deoxynucleotide pool, thereby inhibiting DNA synthesis and cell replication. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39575&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39575&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1208" NCI Thesaurus)
Pyrazofurin definition: A nucleoside analog. Pyrazofurin potently inhibits orotidine 5'-monophosphate (OMP) decarboxylase, thereby interfering with de novo synthesis of uridine nucleotides and resulting in cytotoxicity. This agent also causes a rapid depletion of the pyrimidine deoxynucleotide pool, thereby inhibiting DNA synthesis and cell replication. (NCI04)
Canthaxanthin definition: A trans-carotenoid pigment widely distributed in nature. The compound is used as an oral suntanning agent and as a food and drug coloring agent. Oral ingestion of the compound causes canthaxanthin retinopathy.
Canthaxanthin definition: Carotenoid having a chemical structure similar to beta-carotene with carbonyl (C=O) functions at the number 4 and 4' carbon atoms.
Inhibin-beta Subunits definition: They are glycopeptides and subunits in INHIBINS and ACTIVINS. Inhibins and activins belong to the transforming growth factor beta superfamily.
Inhibin Beta A definition: The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. (from LocusLink)
Adaptor Protein Complex beta Subunits definition: A family of large adaptin protein complex subunits of approximately 90-130 kDa in size.
beta-Crystallin A Chain definition: The acidic subunit of beta-crystallins.
beta-adrenergic receptor activity definition: Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein. [GOC:cb, GOC:mah, IUPHAR_GPCR:1274]
AP-2 Beta definition: A transcription factor that belongs to the AP-2 family and binds viral and cellular enhancers containing the consensus 5'-GCCNNNGGC-3' DNA motif. AP-2 Beta appears to regulate expression of genes required for ectodermal development and retinoic acid-induced differentiation of neuroectodermal cells. (from SWISS-PROT Q92481, OMIM 601601, and NCI)
AP-2 Beta definition: Encoded by human TFAP2B Gene (AP-2 Family), 449-aa 49-kD AP-2 Beta is a sequence-specific dimeric transcription co-activator that binds to 5prime-GCCNNNGGC-3prime DNA sequence in cellular enhancers of many genes involved in retinoic acid-induced neuroectodermal differentiation. AP-2 Beta also suppresses expression of the C/EBP-Alpha, MCAM/MUC18, and c-MYC genes. Unlike the N-terminal activation domain, the DNA-binding and dimerization domains of AP-2-Beta are highly conserved with other family members. AP2-B can form homodimers or heterodimers with AP-2 family members. TFAP2B defects cause of Char syndrome. (from LocusLink, Swiss-Prot, OMIM, and NCI)
beta definition: The beta-distribution is used for data that is bounded on both sides and may or may not be skewed (e.g., occurs when probabilities are estimated.) Two parameters a and b are available to adjust the curve. The mean m and variance s2 relate as follows: m = a/ (a + b) and s2 = ab/((a + b)2 (a + b + 1)).
TFAP2B wt Allele definition: Human TFAP2B wild-type allele is located within 6p21-p12 and is approximately 25 kb in length. This allele, which encodes transcription factor AP-2 beta protein, is involved in gene expression modulation during ectodermal differentiation. Missense mutations of the wild-type allele can lead to autosomal dominant Char syndrome.
beta-Hexosaminidase beta Chain definition: The beta subunit of hexosaminidase A and hexosamininidase B. Mutations in the gene that encodes this protein are linked to SANDHOFF DISEASE and can result in loss of both hexosaminidase A activity and hexosaminidase B activity.
beta definition: Bêta (β, lettre grecque).
 
 
deGerman
albern definition: [1] in unpassender und dummer Art lustig [2] kindisch
 
laLatin
beta definition: Betterave.
 
slSlovenian
beta definition: Bêta (β, lettre grecque).
beta definition: ''Nominatif singulier du nom'' beta.
 
frFrench
betterave definition: Variété de bette à racine charnue.
betterave definition: ''Avoir le nez rouge comme une '''betterave''','' ou ''Avoir un nez de '''betterave''','' Avoir le nez très rouge et bourgeonné.
moi definition: Attachement de quelqu’un à ce qui lui est personnel.
moi definition: Individualité métaphysique d’une personne.
moi definition: L’être humain, unique, différent des autres, dans ses pensées, ses actions; etc.
moi definition: Ma propre personne elle-même.
gourdiflot definition: Personne un peu niaise.
 
idIndonesian
hamba definition: Esclave.
hamba definition: Je, moi, ''(pour se rabaisser)''.
gua definition: Grotte, caverne.