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Definition
 
enEnglish
Epitopes definition: Sites on an antigen that interact with specific antibodies.
Epitope definition: The simplest form of an antigenic determinant, on a complex antigenic molecule, which can combine with antibody or T cell receptor.
Binding Sites definition: The parts of a macromolecule that directly participate in its specific combination with another molecule.
binding site definition: reactive portion of a macromolecule that directly participates in its specific combination with another molecule.
Binding, Competitive definition: The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.
Protein Binding definition: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
protein binding definition: Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). [GOC:go_curators]
protein binding definition: strong physiochemical attraction between proteins and other molecules, including proteins.
Insulin-Like Growth Factor Binding Protein 1 definition: Insulin-like growth factor binding protein 1 (259 aa, 28 kD) is a cell communication protein that is encoded by the human IGFBP1 gene and has a role in signal transduction.
Insulin-Like Growth Factor Binding Protein 1 definition: One of the six homologous proteins that specifically bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions. The function of this protein is not completely defined. However, several studies demonstrate that it inhibits IGF binding to cell surface receptors and thereby inhibits IGF-mediated mitogenic and cell metabolic actions. (Proc Soc Exp Biol Med 1993;204(1):4-29)
binding protein definition: general term for class of proteins whose most important function appears to be binding of some ligand for soluability, transport, bioactivity regulation, or other nonenzymatic process; prefer NTs whenever possible.
Ligand Binding Protein definition: General term for proteins that have binding as a major function.
Ligand Binding Domain definition: A Binding Site Domain is a region of protein that physically interacts stereospecifically, and usually at high affinity, with a specific ligand, substrate, or a specific domain of some complex target biomolecule, such as a protein, lipid, carbohydrate, or nucleic acid. Typically, but not necessarily, the interaction results in protein conformational alteration and functional modification.
antigen binding definition: Interacting selectively with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen. [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
Antigen Binding definition: Antigen Binding Interaction involves specific and high affinity non-covalent interaction (binding) of an endogenous antibody through intermolecular physical forces of attraction and spatial complementarity with a soluble or particulate substance (antigen) that induces an immune response.
bacteriochlorophyll binding definition: Interacting selectively with bacteriochlorophyll, a form of chlorophyll found in photosynthetic bacteria, such as the purple and green bacteria. There are several types, designated a to g. Bacteriochlorophyll a and bacteriochlorophyll b are structurally similar to the chlorophyll a and chlorophyll b found in plants. [ISBN:0192800981]
androgen binding definition: Interacting selectively with any androgen, male sex hormones. [GOC:jl, http://cancerweb.ncl.ac.uk/]
acetylcholine binding definition: Interacting selectively with acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. [GOC:ai]
AT binding definition: OBSOLETE (was not defined before being made obsolete). [GOC:go_curators]
AT DNA binding definition: Interacting selectively with oligo(A) and oligo(T) tracts of DNA (AT DNA). [GOC:jl, UniProtKB:P13483]
AU-rich element binding definition: Interacting selectively with AU-rich elements within the 3' untranslated region of mRNAs. [GOC:mah, PMID:7892223]
AMP binding definition: Interacting selectively with AMP, adenosine monophosphate. [GOC:go_curators]
ATP binding definition: Interacting selectively with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
ADP-ribosylation factor binding definition: Interacting selectively with ARF, ADP-ribosylation factor, a small monomeric cytosolic GTPase that, when bound to GTP, binds to the membranes of cells. [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
actin binding definition: Interacting selectively with monomeric or multimeric forms of actin, including actin filaments. [GOC:clt]
ankyrin binding definition: Interacting selectively with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins. [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
TATA-binding protein binding definition: Interacting selectively with TATA-binding protein (TBP), a component of various transcription factors. [GOC:jl, http://www.mblab.gla.ac.uk/]
TRAIL binding definition: Interacting selectively with TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor ligand family that rapidly induces apoptosis in a variety of transformed cell lines. [GOC:go_curators, PMID:9082980]
bacterial binding definition: Interacting selectively with any part of a bacterial cell. [GOC:jl]
binding definition: The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. [GOC:ceb, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
Molecular Interaction definition: Involves temporary, non-covalent binding of two or more molecules as a result of intermolecular physical forces and often involves spatial complementarity between the interacting objects.
acyl binding definition: Interacting selectively with an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid. [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
auxin binding definition: Interacting selectively with auxin, plant hormones that regulate aspects of plant growth. [GOC:sm]
3,4-didehydroretinal binding definition: Interacting selectively with 3,4-didehydroretinal, a form of retinal that plays a role in the visual process in freshwater fish and some amphibians analogous to that of all-trans retinal in other vertebrates. 3,4-didehydro-11-cis-retinal combines with an opsin to form cyanopsin (cone) or porphyropsin (rod). [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
arachidonic acid binding definition: Interacting selectively with arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. [GOC:ai]
actinin binding definition: Interacting selectively with actinin, any member of a family of proteins that crosslink F-actin. [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
activin binding definition: Interacting selectively with activin, a dimer of inhibin-beta subunits. [GOC:jic, GOC:mah]
beta-2-microglobulin binding definition: Interacting selectively with beta-2-microglobulin. [GOC:mah]
DBD domain binding definition: Interacting selectively with the DBD, DNA binding domain, of a protein. The DNA binding domain of the vitamin D receptor, one of a family of receptors with the DBD, is split into three regions, the P, D and T boxes. Residues that are critical for target sequence selectivity form the P-box. The D-box contains residues that are important for homodimerization of class I nuclear receptors. The T-box is essential for both DNA-binding and transactivation of the VDR; this region may also be important for dimerization with RXR for class II nuclear receptors. [PMID:9682036]
LBD domain binding definition: Interacting selectively with the LBD, the ligand binding domain found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket. [PMID:9682036]
androgen receptor binding definition: Interacting selectively with an androgen receptor. [GOC:ai]
IGFBP1 Gene definition: This gene plays a role in insulin-like growth factor modulation and degradation.
brain-derived neurotrophic factor binding definition: Interacting selectively with brain-derived neurotrophic factor. [GOC:dgh]
ATPase binding definition: Interacting selectively with an ATPase, any enzyme that catalyzes the hydrolysis of ATP. [GOC:ai]
anion binding definition: Interacting selectively with anions, charged atoms or groups of atoms with a net negative charge. [GOC:jl]
amine binding definition: Interacting selectively with any organic compound that is weakly basic in character and contains an amino or a substituted amino group. [GOC:jl]
alcohol binding definition: Interacting selectively with an alcohol, any of a class of alkyl compounds containing a hydroxyl group. [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
alkanesulfonate binding definition: Interacting selectively with alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon moiety. [GOC:mlg]
protein kinase B binding definition: Interacting selectively with protein kinase B, an intracellular kinase that is important in regulating glucose metabolism. [GOC:jl, http://www.heartandmetabolism.org/]
ADP binding definition: Interacting selectively with ADP, adenosine 5'-diphosphate. [GOC:jl]
angiostatin binding definition: Interacting selectively with angiostatin, a proteolytic product of plasminogen or plasmin containing at least one intact kringle domain, and which is an inhibitor of angiogenesis. [PMID:16043488]
serotonin binding definition: Interacting selectively with serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. [GOC:ai]
ALP binding definition: Interacting selectively wih ALP, actinin-associated LIM protein of the Z band. ALP is a PDZ/LIM domain protein found in the Z band. [PMID:11699871]
epinephrine binding definition: Interacting selectively with epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine. [GOC:ai]
adenine binding definition: Interacting selectively with adenine, a purine base. [GOC:hjd]
pyrimidine binding definition: Interacting selectively with a pyrimidine, an organic nitrogenous base. [GOC:hjd]
acrosin binding definition: Interacting selectively with acrosin, a protein that is found in the acrosomes of sperm and possesses protease and carbohydrate binding activities. [GOC:mah, PMID:12398221]
amide binding definition: Interacting selectively with an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. [ChEBI:32988, GOC:mah]
2-aminoethylphosphonate binding definition: Interacting selectively with 2-aminoethylphosphonate. [GOC:mlg]
apolipoprotein binding definition: Interacting selectively with an apolipoprotein, the protein component of a lipoprotein complex. [GOC:rl]
adiponectin binding definition: Interacting selectively with adiponectin, a protein hormone produced by adipose tissue that modulates a number of metabolic processes, including glucose regulation and fatty acid catabolism. [GOC:rl, PMID:15210937]
nitric oxide binding definition: Interacting selectively with nitric oxide (NO). [GOC:ecd]
aspartate binding definition: Interacting selectively with glutamate, the anion of 2-aminobutanedioic acid. [GOC:mah]
abscisic acid binding definition: Interacting selectively with abscisic acid, plant hormones that regulate aspects of plant growth. [PMID:17347412]
21U-RNA binding definition: Interacting selectively with a 21U-RNA, a 21-nucleotide RNA characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome. [GOC:kmv]
tetrahydrobiopterin binding definition: Interacting selectively with a tetrahydrobiopterin, 5,6,7,8-tetrahydrobiopterin or a derivative thereof; tetrahydrobiopterins are enzyme cofactors that carry electrons in redox reactions. [ChEBI:15372, GOC:mah, GOC:rl]
arginine binding definition: Interacting selectively with 2-amino-5-(carbamimidamido)pentanoic acid. [ChEBI:29016, GOC:rl]
binding definition: Bande, bandeau, galon (d'ameublement), reliure.
binding definition: en informatique, module de liaison d'une bibliothèque pour un autre langage de programmation
bookbinding definition: Reliure.
 
 
deGerman
Bund definition: [1] politisch: eine Gruppe von souveränen Staaten, die sich für eine gemeinsame (Teil-)Politik zusammentun [2] politisch: höchste Verwaltungsebene eines föderal gegliederten Staates [3] hüftseitiges Ende, die Verstärkung an Kleidungsstücken [4] gegenseitige Verpflichtung von Gleichgesinnten [5] Verstärkung am Ende eines Rohres [6] Recht: juristischer Zusammenschluss [7] Buchbinderei: Bund eines Buches, Buchbindung [8] soziologische Kategorie [9] Musik: Erhebungen im Griffbrett bei Zupf- und Saiteninstrumenten zur Veränderung der Tonhöhen [10] ein Bündel; etwas, das zusammengebunden oder zusammengeschnürt ist [11] altes Maß, Maßeinheit für Tafelglas [12]
unverbindlich definition: [1] nicht verbindlich, ohne Festlegung [2] höflich, aber ohne freundliches Entgegenkommen, kurz angebunden
verbindlich definition: [1] entgegenkommend, freundlich [2] bindend
 
nlDutch
band definition: Bande, raie, rayure.
band definition: Ruban.
band definition: Bord, lisière.
band definition: Orchestre.
band definition: Bande, bandeau.
 
frFrench
reliure definition: Métier du relieur, art de relier les livres.
reliure definition: Ouvrage d’un relieur ; de la manière dont un livre est relié.
bandeau definition: Bande qui sert à ceindre le front et la tête.
bandeau definition: Bande, ou d’un morceau d’étoffe en plusieurs doubles, qu’on met sur les yeux de quelqu’un pour l’empêcher de voir.
bandeau definition: Espèce d’aveuglement moral qui naît d’une passion, d’une prévention, ou d’ignorance.
bandeau definition: Plate-bande unie, en saillie sur le nu du mur autour d’une baie de porte ou de fenêtre, destinée à tenir lieu de chambranle.
bandeau definition: Vignette gravée, en forme de frise, en tête de chapitre.
bandeau definition: Partie placée en haut d’une page de une, occupant généralement toute la largeur du journal.