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biphenyl compound definition: class of compounds containing two linked benzene rings.
Polybrominated Biphenyls definition: Biphenyl compounds which are extensively brominated. Many of these compounds are toxic environmental pollutants.
Polybrominated Biphenyl definition: A mixture of synthetic solids, containing three or more bromine atoms, that is virtually insoluble in water but is soluble in fat and various organic solvents. There are 209 different molecular combinations, or congeners, that are possible for polybrominated biphenyls. These mixtures are no longer used or produced in commercial quantities in the United States. Residues remaining in and around plants that formerly manufactured, processed or produced products using polybrominated biphenyls are the current sources for human exposure. The primary routes of potential human exposure to polybrominated biphenyls are ingestion, inhalation, and dermal contact. A commercial mixture of these compounds is reasonably anticipated to be a human carcinogen. (NCI05)
Polychlorinated Biphenyls definition: Industrial products consisting of a mixture of chlorinated biphenyl congeners and isomers. These compounds are highly lipophilic and tend to accumulate in fat stores of animals. Many of these compounds are considered toxic and potential environmental pollutants.
Polychlorinated Biphenyl definition: Polychlorinated Biphenyls (PCBs) are a family of more than 200 chemical compounds (congeners) with 1 to 10 chlorine atoms attached to biphenyl and a general structure of C12H10-xClx. PCBs were commercially produced as complex mixtures of congeners at different degrees of chlorination for a variety of applications. Their use was based on their chemical stability, and desirable physical properties. According to WHO, several congeners are now considered to be "dioxin-like" because of their toxicity and certain features of their structure similar to 2,3,7,8-tetrachlorodibenzo-p-dioxin. PCBs are not readily biodegradable, their use declined and was essentially terminated because of environmental concerns. USA stopped producing PCBs in 1977. (NCI)
biphenyl 2,3-dioxygenase activity definition: Catalysis of the reaction: biphenyl + NADH + H+ + O2 = (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD; requires Fe2+. [EC:]
biphenyl metabolic process definition: The chemical reactions and pathways involving biphenyl, a toxic aromatic hydrocarbon used as a heat transfer agent, as a fungistat in packaging citrus fruits and in plant disease control. Biphenyl can be chlorinated with 1-10 chlorine molecules to form polychlorinated biphenyls (PCBs). [GOC:jl]
Biphenyl Hydrolase-Like Protein definition: Encoded by human BPHL Gene (Serine Hydrolase Family), 274-amino acid 30 kD Biphenyl Hydrolase-Related Protein, with structural similarity to enzymes involved in degradation of aromatic compounds, has a putative role in detoxification processes. Highest expression occurs in liver and kidney. Serine hydrolases contain serine in their active site and are grouped into subfamilies in terms of substrate specificity or amino acid sequence. (from Swiss-Prot Q00306, OMIM 603156, and NCI)
BPHL Gene definition: This gene is involved in prodrug activation.
biphenyl synthase activity definition: Catalysis of the reaction: 3 malonyl-CoA + benzoyl-CoA = 4 CoA + 3,5-dihydroxybiphenyl + 4 CO2. [EC:]