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Calcium-Transporting ATPases definition: Cation-transporting proteins that utilize the energy of ATP hydrolysis for the transport of CALCIUM. They differ from CALCIUM CHANNELS which allow calcium to pass through a membrane without the use of energy.
calcium transporting ATPase definition: family of ATP-driven, transmembrane molecular pumps which maintain concentration gradients of calcium across a variety of cell membranes, the most notable being sarcoplasmic reticulum term not valid for FY 92.
Calcium definition: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
calcium definition: basic element found in nearly all organized tissues; a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40; it is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth; it is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation and in many enzymatic processes.
calcium definition: (KAL-see-um) A mineral found in teeth, bones, and other body tissues.
Calcium definition: An element with atomic symbol Ca, atomic number 20, and atomic weight 40.08.
Calcium Carbonate definition: Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically as a phosphate buffer in hemodialysis patients and as a calcium supplement.
calcium carbonate definition: carbonic acid calcium salt (CaCO3) used therapeutically as a phosphate buffer in hemodialysis patients and as a calcium supplement.
calcium carbonate definition: A mineral taken primarily as a supplement to prevent osteoporosis. It is also being studied for cancer prevention.
calcium carbonate definition: The carbonic salt of calcium (CaCO3). Calcium carbonate is used therapeutically as a phosphate buffer in hemodialysis, as an antacid in gastric hyperacidity for temporary relief of indigestion and heartburn, and as a calcium supplement for preventing and treating osteoporosis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39679&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39679&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C332" NCI Thesaurus)
Calcium Carbonate definition: The carbonic salt of calcium (CaCO3). Calcium carbonate is used therapeutically as a phosphate buffer in hemodialysis, as an antacid in gastric hyperacidity for temporary relief of indigestion and heartburn, and as a calcium supplement for preventing and treating osteoporosis. (NCI04)
Calcium Channel Blockers definition: A class of drugs that act by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools. Since they are inducers of vascular and other smooth muscle relaxation, they are used in the drug therapy of hypertension and cerebrovascular spasms, as myocardial protective agents, and in the relaxation of uterine spasms.
calcium channel blocker definition: class of drugs that act by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools; since they are inducers of vascular and other smooth muscle relaxation, they are used in the drug therapy of hypertension and cerebrovascular spasms, as myocardial protective agents, and in the relaxation of uterine spasms.
Calcium Channels definition: Voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions. They are categorized as L-, T-, N-, P-, Q-, and R-types based on the activation and inactivation kinetics, ion specificity, and sensitivity to drugs and toxins. The L- and T-types are present throughout the cardiovascular and central nervous systems and the N-, P-, Q-, & R-types are located in neuronal tissue.
calcium channel definition: voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions.
Calcium Channel definition: An ion channel with selective permeability to calcium.
Calcium Chloride definition: A salt used to replenish calcium levels, as an acid-producing diuretic, and as an antidote for magnesium poisoning.
Calcium Chloride definition: A crystalline, white substance, soluble in water, Calcium Chloride is the chloride salt of calcium, a bivalent metallic element with many crucial biological roles. Calcium is a major constituent of the skeleton but plays many roles as an intracellular and plasma ion as well. In medicine, calcium chloride is also used as a 10% solution in injection, for calcium replenishment. (NCI04)
Edetate Calcium Disodium definition: Contracted name for a salt of ethylenediaminetetraacetate, an agent used as a chelator of lead and some other heavy metals. C10H12CaN2Na2O8.
Calcium Dobesilate definition: A drug used to reduce hemorrhage in diabetic retinopathy.
Calcium Fluoride definition: Calcium fluoride. Occurring in nature as the mineral fluorite or fluorspar. It is the primary source of fluorine and its compounds. Pure calcium fluoride is used as a catalyst in dehydration and dehydrogenation and is used to fluoridate drinking water. (From Merck Index, 11th ed)
calcium phosphate definition: calcium salts containing the phosphate radical (PO4), frequently used as calcium supplements.
Calcium Pyrophosphate definition: An inorganic pyrophosphate which affects calcium metabolism in mammals. Abnormalities in its metabolism occur in some human diseases, notably HYPOPHOSPHATASIA and pseudogout (CHONDROCALCINOSIS).
Calcium Sulfate definition: A calcium salt that is used for a variety of purposes including: building materials, as a desiccant, in dentistry as an impression material, cast, or die, and in medicine for immobilizing casts and as a tablet excipient. It exists in various forms and states of hydration. Plaster of Paris is a mixture of powdered and heat-treated gypsum.
Calcium, Dietary definition: Calcium compounds used as food supplements or in food to supply the body with calcium. Dietary calcium is needed during growth for bone development and for maintenance of skeletal integrity later in life to prevent osteoporosis.
dietary calcium definition: calcium compounds used as food supplements or in food to supply the body with calcium; dietary calcium is needed during growth for bone development and for maintenance of skeletal integrity later in life to prevent osteoporosis.
Dietary Calcium definition: Forms of the element calcium found in foods.
Calcium Chromate definition: A yellowish, crystalline, inorganic compound that emits toxic chromium fumes upon heating. Calcium chromate is highly corrosive and is a strong oxidizing agent. This substance is mainly used as a corrosion inhibitor and as a depolarizer in batteries. Calcium chromate primarily affects the nose, throat and lungs causing ulcerations, shortness of breath, bronchitis, pneumonia and asthma-like allergy but can also affect the gastrointestinal tract, liver, kidneys and immune system. This substance is a known human carcinogen and is associated with an increased risk of developing lung cancer and cancer of the sinonasal cavity. (NCI05)
Calcium Citrate definition: A colorless crystalline or white powdery organic, tricarboxylic acid occurring in plants, especially citrus fruits, and used as a flavoring agent, as an antioxidant in foods, and as a sequestrating agent. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
calcium citrate definition: The citrate salt of calcium. An element necessary for normal nerve, muscle, and cardiac function, calcium as the citrate salt helps to maintain calcium balance and prevent bone loss when taken orally. This agent may also be chemopreventive for colon and other cancers. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41817&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41817&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1355" NCI Thesaurus)
Calcium Citrate definition: The citrate salt of calcium. An element necessary for normal nerve, muscle, and cardiac function, calcium as the citrate salt helps to maintain calcium balance and prevent bone loss when taken orally. This agent may also be chemopreventive for colon and other cancers. (NCI04)
Analyzers, Laboratory, Body Fluid, Calcium definition: Laboratory analyzers used to measure the concentration of ionized calcium (Ca++), total calcium, or both in whole blood, plasma, serum, and other body fluids. These analyzers typically use electrochemical (ion-selective electrode) sensors to measure ionized calcium and fluorescence-quenching techniques for measuring total calcium. Many analyzers include an electrode for pH measurement or calculate the Ca++ content at a pH corrected value of 7.4, due its dependence on pH. Dedicated calcium analyzers are used to determine low- and high- serum calcium concentrations related to several diseases and the consumption of certain drugs and/or food. They are used in the course of some major surgical procedures.
Calcium Measurement definition: A quantitative measurement of the amount of calcium present in a sample.
Calcium definition: A measurement of the calcium in a biological specimen.
Calcium Compounds definition: Inorganic compounds that contain calcium as an integral part of the molecule.
Atorvastatin Calcium definition: The calcium salt of atorvastatin, a synthetic lipid-lowering agent. Atorvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent increases the number of LDL receptors on hepatic cell surfaces, enhancing the uptake and catabolism of LDL and reducing LDL production and the number of LDL particles, and lowers plasma cholesterol and lipoprotein levels. Like other statins, atorvastatin may also display direct antineoplastic activity, possibly by inhibiting farnesylation and geranylgeranylation of proteins such as small GTP-binding proteins, which may result in the arrest of cells in the G1 phase of the cell cycle. This agent may also sensitize tumor cells to cyctostatic drugs, possibly through the mTOR-dependent inhibition of Akt phosphorylation.
calcium disorder definition: condition in which there is a deviation or interruption in the processing of calcium in the body, its absorption, transport, storage, and utilization.
pentetic acid calcium definition: A drug that protects healthy tissues from the toxic effects of anticancer drugs.
pentetic acid calcium definition: A synthetic chelating agent related to EDTA. Pentetic acid calcium chelates with the metallic radioisotopic moieties of unbound, extracellular radioimmunotherapeutic agents, resulting in higher specific tumor cell binding of radioimmunotherpeutic agents, and so improved tumor cell radiocytotoxicity, while sparing normal cells and tissues from the radiocytotoxic effects of these agents. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42562&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42562&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1710" NCI Thesaurus)
Pentetic Acid Calcium definition: The calcium salt of pentetic acid, a synthetic chelating agent related to the chelating agent ethylenediaminetetraacetic acid (EDTA). Pentetic acid chelates with the metallic radioisotopic moieties of unbound, extracellular radioimmunotherapeutic agents, resulting in higher specific tumor cell binding of radioimmunotherapeutic agents; this results in improved tumor cell radiocytotoxicity and the sparing of normal cells and tissues from the radiocytotoxic effects of these agents.
calcium flux definition: large scale movement of calcium ions at the cellular level, as across the cell membrane, between organelles, or through the cytoplasm; a fundamental cellular signal transduction mechanism; do not confuse with CALCIUM METABOLISM, which applies to bodily balance.
calcium ion definition: divalent cation essential in cellular signal transduction and the normal functioning of nerves and muscles; plays a role in blood coagulation and in many enzymatic processes.
Calcium Cation definition: The metabolically-active portion of calcium, not bound to proteins, circulating in the blood.
Ca2+ definition: Calcium ion requiring two electrons to return to its elemental state.
Calcium Acetate definition: A calcium salt of acetic acid. Calcium is a mineral essential for many cellular functions including nerve impulse transmission, muscle contraction, cardiac function, bone formation, and capillary and cell membrane permeability. Calcium acetate is administered orally to prevent or treat calcium deficiency and to treat hyperphosphatemia due to its phosphate-binding properties.
leucovorin calcium definition: An active metabolite of folic acid (also called folinic acid and citrovorum factor), which does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist-type chemotherapeutic drugs. Leucovorin calcium counteracts the toxic effects of these medications, 'rescuing' the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug's metabolite to its target enzyme, thus prolonging drug activity. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42584&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42584&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C607" NCI Thesaurus)
Leucovorin Calcium definition: An active metabolite of folic acid (also called folinic acid and citrovorum factor), which does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist-type chemotherapeutic drugs. Leucovorin calcium counteracts the toxic effects of these medications, 'rescuing' the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug's metabolite to its target enzyme, thus prolonging drug activity. (NCI04)
Calcium Binding definition: Calcium Binding consists of a biophysical interaction between one or more calcium ion(s) and a biological molecule, such as a protein. Calcium binding with proteins often involves interaction of the ion(s) with a specific region, domain, or motif (e.g., EF-Hand) that supports protein structure or induces an alteration of protein activity in enzymatic or cell signaling cascades.
calcification definition: Deposits of calcium in the tissues. Calcification in the breast can be seen on a mammogram, but cannot be detected by touch. There are two types of breast calcification, macrocalcification and microcalcification. Macrocalcifications are large deposits and are usually not related to cancer. Microcalcifications are specks of calcium that may be found in an area of rapidly dividing cells. Many microcalcifications clustered together may be a sign of cancer.
Calcification definition: Deposition of calcium in the tissues. It may be the result of a metabolic disorder or long-standing infection, or it may be associated with the presence of cancer. -- 2004
calcium definition: [1] Calcium
calcium definition: Calcium, l’élément chimique.
calcium definition: Calcium, l’ion.
calcium definition: Calcium, le métal.
 
 
deGerman
Calcium definition: [1] chemisches Element mit der Ordnungszahl 20, das zur Gruppe der Erdalkalimetalle gehört
Calciumcitrat definition: [1] Das Calciumcitrat ist das Calciumsalz der Citronensäure.
Calcium definition: Calcium.
 
ltLithuanian
kalcis definition: [1] Kalzium
 
hyArmenian
կալցիում definition: [1] Chemie: Calcium
 
frFrench
calcium definition: [1] Calcium
calcium definition: Élément chimique de numéro atomique 20 et de symbole '''Ca''' qui fait partie des métaux alcalino-terreux.
calcium definition: L’ion de cet élément, noté Ca2+ ou Ca++.
calcium definition: Métal gris et mou, forme métallique pure de l’élément.
 
itItalian
benzoato di calcio definition: [1] Calciumbenzoat, Calciumverbindung der Benzoesäure
 
euBasque
kaltzio definition: [1] Chemie: Calcium
 
nlDutch
calcium definition: Calcium.