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Definition
 
enEnglish
Carcinogenicity Tests definition: Tests to experimentally measure the tumor-producing/cancer cell-producing potency of an agent by administering the agent (e.g., benzanthracenes) and observing the quantity of tumors or the cell transformation developed over a given period of time. The carcinogenicity value is usually measured as milligrams of agent administered per tumor developed. Though this test differs from the DNA-repair and bacterial microsome MUTAGENICITY TESTS, researchers often attempt to correlate the finding of carcinogenicity values and mutagenicity values.
carcinogen testing definition: tests to experimentally measure the tumor producing or cancer cell producing potency of an agent by administering the agent and observing the quantity of tumors or the cell transformation developed over a given period of time; the carcinogenicity value is usually measured as milligrams of agent administered per tumor developed.
Anticarcinogenic Agents definition: Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved. They differ from antineoplastic agents in that they prevent neoplasms from forming. The anticarcinogenic substances can be divided into three categories. The first consists of compounds that prevent the formation of carcinogens from precursor substances. The second group consists of "blocking agents" which inhibit carcinogenesis by preventing carcinogenic agents from reaching or reacting with critical target sites in the tissues. The third group is the "suppressor agents" which act by suppression of expression of neoplasia in cells previously exposed to carcinogens that would otherwise cause neoplasms.
Carcinogenic Intervention definition: Treatment or procedure that the animal model was exposed to in order to initiate or support the development of neoplastic lesions.
Carcinogenic Anthraquinone definition: A compound that increases the risk of human cancer and is mainly used in the manufacture of dyes. These compounds consist of an anthracene ring that contains two ketone moieties in any position and can be substituted in any position except on the ketone groups. (NCI05)
Carcinogenic Brominated Hydrocarbon definition: A hydrocarbon compound consisting of carbons with one or more bromide atom incorporated in its structure that can increase the risk of human cancer. (NCI05)
Carcinogenic Chlorinated Hydrocarbon definition: A hydrocarbon compound consisting of carbons with one or more chloride atom incorporated in its structure that can increase the risk of human cancer. (NCI05)
Carcinogenic Cyclic Nitrosamine definition: A ring compound that increases the risk of human cancer and is a N-nitroso derivative of secondary amines (R2N-NO), formed by combining nitrates with amines. (NCI05)
Carcinogenic Epoxide definition: A ring-shaped organic compound that can potentially cause cancer in humans and consists of an oxygen atom bonded to two other atoms, usually of carbon, that are already bonded to each other. (NCI05)
Carcinogenic Fluorinated Hydrocarbon definition: A hydrocarbon compound consisting of carbons with one or more fluoride atom incorporated in its structure that can increase the risk of human cancer. (NCI05)
Carcinogenic Halogenated Aromatic Hydrocarbon definition: A compound that can increase human cancer risk and consists of hydrogen and carbon atoms arranged in a symmetrical 6-carbon ring structure with single and double bonds alternating around the ring (benzene ring) and in which at least one of the hydrogen atoms is substituted for a halogen (chlorine, bromine, fluorine) atom. These carcinogenic compounds can have single, double or multiple fused rings and can have other chemical groups attached to them in place of hydrogen. (NCI05)
Carcinogenic Halogenated Hydrocarbon definition: Molecules with carcinogenic activity that almost entirely consist of carbon and hydrogen that may be cyclic or non-cyclic structures with single, double bonds or both but have at least one halogen element (chloride, bromide, fluoride, iodide, astatine) atom substituted for one of the hydrogen atoms. (NCI05)
Carcinogenic Hydrocarbon definition: An organic compound that is likely to cause cancer and contains only carbon and hydrogen that can be arranged in rows, rings, or both, and connected by single, double or triple bonds. Carcinogenic hydrocarbons are often found in petroleum, natural gas and coal and are capable of causing cancer. (NCI05)
Carcinogenic Metal definition: An electropositive element that can increase the risk of human cancer and is characterized by ductility, malleability, luster, the ability to conduct heat and electricity and the tendency to lose rather than gain electrons in chemicals. (NCI05)
Carcinogenic Mineral definition: An inorganic, crystalline solid substance with a well-defined chemical composition and with characteristic physical properties that is found in nature and has the ability to increase human cancer risk. (NCI05)
Carcinogenic Mixture definition: A compound that consists of a combination of more than one substance that can cause cancer in humans. (NCI05)
Carcinogenic Nitrosamine definition: An organic N-nitroso compound with possible carcinogenic activity characterized by the group -NNO or -NHNO in its structure, formed by combining nitrates with amines. These compounds are found in various foods and many are carcinogenic or are suspected carcinogens. Cured meats can contain nitrosamines because meats contain amines and can react during cooking with sodium nitrite that is added as a preservative. (NCI05)
Carcinogenic Nitrosourea definition: Any of several chemically related nitrosourea-derivates that increases the risk of human cancer and are highly lipid-soluble and act by alkylation, carbamoylation, and inhibition of DNA repair. (NCI05)
Carcinogenic Polycyclic Aromatic Hydrocarbon definition: Carcinogenic Polycyclic Aromatic Hydrocarbons (PAH) are ubiquitous environmental pollutants that are formed in the process of incomplete burning of organic material and can cause cancer in humans. PAH molecules are made up of two or more fused aromatic rings. PAH causes a carcinogenic effect by metabolic activation to diol epoxides, which bind covalently to DNA. (NCI05)
Carcinogenic Salt definition: A chemical substance that can potentially cause cancer in humans and is produced from the reaction between acids and bases and consists of electropositive and electronegative radicals. (NCI05)
Carcinogenic Aromatic Amine definition: Potentially cancer-causing compound containing amine with an aromatic ring substituted for one or more of its hydrogen atoms, i.e., -NH2, -NH- or nitrogen group(s) attached to an aromatic hydrocarbon, whose structure usually contains one or more benzene rings. This group includes many industrial and tobacco carcinogens. (NCI05)
 
 
deGerman
krebserregend definition: [1] die Krankheit Krebs auslösend
 
frFrench
carcinogène definition: Substance qui peut provoquer un cancer.