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Carcinoma definition: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
carcinoma definition: malignant new growth arising from epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases.
epithelial carcinoma definition: (ep-ih-THEE-lee-ul kar-sin-O-ma) Cancer that begins in the cells that line an organ.
epithelial carcinoma definition: (kar-sin-O-ma) Cancer that begins in the skin or in tissues that line or cover internal organs.
Carcinoma definition: A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas. Morphologically, the malignant epithelial cells may display abnormal mitotic figures, anaplasia, and necrosis. Carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Carcinomas invade the surrounding tissues and tend to metastasize to other anatomic sites. Lung carcinoma, skin carcinoma, breast carcinoma, colon carcinoma, and prostate carcinoma are the most frequently seen carcinomas.
Carcinoma in Situ definition: A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.
in situ cancer definition: (kar-sin-O-ma in SYE-too) Cancer that involves only the cells in which it began and that has not spread to neighboring tissues.
Carcinoma In Situ definition: A malignant epithelial neoplasm which is confined to the epithelial layer without evidence of further tissue invasion.
Carcinoma, Basal Cell definition: A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)
basal cell carcinoma definition: malignant skin neoplasm that seldom metastasizes but has potential for local invasion and destruction; clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid); develops on hair-bearing skin, most commonly on sun exposed areas.
basal cell carcinoma definition: (BAY-sal sel kar-sin-O-ma) A type of skin cancer that arises from the basal cells, small round cells found in the lower part (or base) of the epidermis, the outer layer of the skin.
Skin Basal Cell Carcinoma definition: The most frequently seen skin cancer. It arises from basal cells of the epidermis and pilosebaceous units. Clinically it is divided into the following types: nodular, ulcerative, superficial, multicentric, erythematous, and sclerosing or morphea-like.. More than 95% of these carcinomas occur in patients over 40. They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck and the remaining 15% on the trunk and extremities. Basal cell carcinoma usually grows in a slow and indolent fashion. However, if untreated, the tumor may invade the subcutaneous fat, skeletal muscle and bone. Distant metastases are rare. Excision, curettage and irradiation cure most basal cell carcinomas.
Carcinoma, Basosquamous definition: A skin carcinoma that histologically exhibits both basal and squamous elements. (From Dorland, 27th ed)
basosquamous cell carcinoma definition: skin carcinoma that histologically exhibits both basal and squamous elements.
Skin Basosquamous Cell Carcinoma definition: A basal cell carcinoma which displays squamous differentiation. The neoplastic cells have more abundant cytoplasm with more marked keratinization than typical basal cell carcinomas. It usually has a more aggressive clinical course compared to typical basal cell carcinoma, and it may produce regional or widespread metastases.
Adenocarcinoma, Bronchiolo-Alveolar definition: A carcinoma thought to be derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli. Involvement may be uniformly diffuse and massive, or nodular, or lobular. The neoplastic cells are cuboidal or columnar and form papillary structures. Mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells. Metastases in regional lymph nodes, and in even more distant sites, are known to occur, but are infrequent. (From Stedman, 25th ed)
Bronchioloalveolar Carcinoma definition: A well or moderately differentiated morphologic variant of lung adenocarcinoma characterized by tumor growth along the alveolar structures without stromal, vascular, or pleural invasion.
Carcinoma, Bronchogenic definition: Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.
bronchogenic carcinoma definition: group of carcinomas of the lung, arising from the epithelium of the bronchial tree.
Bronchogenic Carcinoma definition: A lung carcinoma arising from the bronchial epithelium. (NCI05)
Carcinoma, Squamous Cell definition: A carcinoma derived from stratified squamous epithelium. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
squamous cell carcinoma definition: (SKWAY-mus sel kar-sin-O-ma) Cancer that begins in squamous cells, which are thin, flat cells that look like fish scales. Squamous cells are found in the tissue that forms the surface of the skin, the lining of the hollow organs of the body, and the passages of the respiratory and digestive tracts. Also called epidermoid carcinoma.
squamous cell carcinoma definition: (ep-i-DER-moyd kar-sin-O-ma) A type of cancer in which the cells are flat and look like fish scales. Also called squamous cell carcinoma.
squamous cell carcinoma definition: carcinoma developed from squamous epithelium.
Squamous Cell Carcinoma definition: A carcinoma arising from squamous epithelial cells. Morphologically, it is characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous cell carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Well differentiated carcinomas are usually associated with keratin production and the presence of intercellular bridges between adjacent cells. Representative examples are lung squamous cell carcinoma, skin squamous cell carcinoma, and cervical squamous cell carcinoma.
Carcinoma, Adenoid Cystic definition: Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)
adenoid cystic cancer definition: A rare type of cancer that usually begins in the salivary glands.
Adenoid Cystic Carcinoma definition: A malignant tumor arising from the epithelial cells. Microscopically, the neoplastic epithelial cells form cylindrical spatial configurations (cribriform or classic type of adenoid cystic carcinoma), cordlike structures (tubular type of adenoid cystic carcinoma), or solid structures (basaloid variant of adenoid cystic carcinoma). Adenoid cystic carcinomas mostly occur in the salivary glands. Other primary sites of involvement include the lacrimal gland, the larynx, and the lungs. Adenoid cystic carcinomas spread along nerve sheaths, resulting in severe pain, and they tend to recur. Lymph node metastases are unusual; hematogenous tumor spread is characteristic.
Lip Carcinoma definition: A malignant epithelial neoplasm arising from the lips.
Esophageal Carcinoma definition: A malignant epithelial tumor arising from the esophageal mucosa. Two major histologic types of esophageal carcinoma have been described: squamous cell carcinoma and adenocarcinoma. This type of cancer is associated with excessive ethanol and cigarette usage. --2002
Undifferentiated Carcinoma definition: A usually aggressive malignant epithelial neoplasm composed of atypical cells which do not display evidence of glandular, squamous, or transitional cell differentiation.
Carcinoma, Adenosquamous definition: A mixed adenocarcinoma and squamous cell or epidermoid carcinoma.
Adenosquamous Carcinoma definition: A carcinoma composed of malignant glandular cells and malignant squamous cells.
Carcinoma, Acinar Cell definition: A malignant tumor arising from secreting cells of a racemose gland, particularly the salivary glands. Racemose (Latin racemosus, full of clusters) refers, as does acinar (Latin acinus, grape), to small saclike dilatations in various glands. Acinar cell carcinomas are usually well differentiated and account for about 13% of the cancers arising in the parotid gland. Lymph node metastasis occurs in about 16% of cases. Local recurrences and distant metastases many years after treatment are common. This tumor appears in all age groups and is most common in women. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1240; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)
Acinar Cell Carcinoma definition: A malignant glandular epithelial neoplasm consisting of secretory cells forming acinar patterns. Representative examples include the acinar cell carcinoma of the pancreas and the acinar adenocarcinoma of the prostate gland.
Adrenocortical Carcinoma definition: A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.
Adrenal Cortex Carcinoma definition: A rare, usually large (greater than 5cm), malignant epithelial tumor arising from the adrenal cortical cells. Symptoms are usually related to the excessive production of hormones, and include Cushing's syndrome and virilism in women. Common sites of metastasis include liver, lung, bone, and retroperitoneal lymph nodes. Advanced radiologic procedures have enabled the detection of small tumors, resulting in the improvement of the 5-year survival.
Carcinoma, Skin Appendage definition: A malignant tumor of the skin appendages, which include the hair, nails, sebaceous glands, sweat glands, and the mammary glands. (From Dorland, 27th ed)
Adnexal Carcinoma definition: A carcinoma arising from the sebaceous glands, sweat glands, or the hair follicles. Representative examples include sebaceous carcinoma, apocrine carcinoma, eccrine carcinoma, and pilomatrical carcinoma.
Gallbladder Carcinoma definition: A malignant tumor arising from the epithelium of the gallbladder. It is associated with the presence of gallstones. Clinical symptoms are not specific and usually present late in the course. Morphologically, most gallbladder carcinomas are adenocarcinomas; squamous cell carcinomas, adenosquamous carcinomas, signet ring carcinomas, and undifferentiated carcinomas can also occur. -- 2004
pancreatic cancer definition: A disease in which malignant (cancer) cells are found in the tissues of the pancreas. Also called exocrine cancer.
Pancreatic Carcinoma definition: A carcinoma arising from the exocrine pancreas. The overwhelming majority of pancreatic carcinomas are adenocarcinomas. --2002
Nasopharyngeal Carcinoma definition: A carcinoma within the nasopharynx.
Nasopharyngeal Carcinoma definition: A carcinoma arising from the nasopharyngeal epithelium. It includes the following types: keratinizing squamous cell carcinoma, nonkeratinizing carcinoma (differentiated and undifferentiated), basaloid squamous cell carcinoma, and papillary adenocarcinoma.
Nasopharyngeal Carcinoma definition: (LIM-fo-EP-ih-THEE-lee-O-ma) A type of cancer that begins in the tissues covering the nasopharynx (the upper part of the throat behind the nose).
Ampulla of Vater Carcinoma definition: A carcinoma arising from the ampulla of Vater. The vast majority of cases are adenocarcinomas. Signs and symptoms include jaundice, abdominal pain, anorexia, nausea, vomiting, and weight loss.
Anal Carcinoma definition: A carcinoma that arises from the anus. Anal carcinomas include the anal canal and anal margin (perianal skin) carcinomas. The anal margin carcinoma is staged separately as a skin carcinoma. Anal cancer stage terms are usually used as synonyms for anal canal cancer stage terms. -- 2003
Cervical Carcinoma definition: Cervical carcinoma may arise from either the exocervical squamous epithelium or the endocervical glandular epithelium. The major histologic types of cervical carcinoma are: squamous carcinoma, adenocarcinoma, adenosquamous carcinoma, adenoid cystic carcinoma and undifferentiated carcinoma.
Pituitary Gland Acidophil Carcinoma definition: A malignant epithelial neoplasm of the anterior pituitary gland in which the neoplastic cells stain positive with acidic dyes.
Basophilic Adenocarcinoma definition: A malignant epithelial neoplasm of the anterior pituitary gland in which the neoplastic cells stain positive with basic dyes.
Endometrial Carcinoma definition: A malignant tumor arising from the epithelium that lines the cavity of the uterine body. The vast majority of endometrial carcinomas are adenocarcinomas; squamous cell and adenosquamous carcinomas represent a minority of the cases. Endometrioid adenocarcinoma is the most frequently seen variant of endometrial adenocarcinoma. Uterine bleeding is an initial clinical sign. The prognosis depends on the stage of the tumor, the depth of myometrial wall invasion, and the degree of differentiation. -- 2004
laryngeal cancer definition: (luh-RIN-jee-ul KAN-ser) Cancer that forms in tissues of the larynx (area of the throat that contains the vocal cords and is used for breathing, swallowing, and talking). Most laryngeal cancers are squamous cell carcinomas (cancer that begins in flat cells lining the larynx).
Laryngeal Carcinoma definition: Carcinoma that arises from the laryngeal epithelium. More than 90% of laryngeal carcinomas are squamous cell carcinomas. The remainder are adenoid cystic carcinomas, mucoepidermoid carcinomas and carcinomas with neuroendocrine differentiation. --2002
ovarian epithelial cancer definition: (ep-ih-THEE-lee-ul) Cancer that occurs in the cells lining the ovaries.
Ovarian Carcinoma definition: A malignant neoplasm originating from the surface ovarian epithelium. It accounts for the greatest number of deaths from malignancies of the female genital tract and is the fifth leading cause of cancer fatalities in women. It is predominantly a disease of older white women of northern European extraction, but it is seen in all ages and ethnic groups. Adenocarcinomas constitute the vast majority of ovarian carcinomas. The pattern of metastatic spread in ovarian carcinoma is similar regardless of the microscopic type. The most common sites of involvement are the contralateral ovary, peritoneal cavity, para-aortic and pelvic lymph nodes, and liver. Lung and pleura are the most common sites of extra-abdominal spread. The primary form of therapy is surgical. The overall prognosis of ovarian carcinoma remains poor, a direct result of its rapid growth rate and the lack of early symptoms. --2002
breast cancer definition: (brest KAN-ser) Cancer that forms in tissues of the breast, usually the ducts (tubes that carry milk to the nipple) and lobules (glands that make milk). It occurs in both men and women, although male breast cancer is rare.
Breast Carcinoma definition: A carcinoma arising from the breast, most commonly the terminal ductal-lobular unit. It is the most common malignant tumor in females. Risk factors include country of birth, family history, menstrual and reproductive history, fibrocystic disease and epithelial hyperplasia, exogenous estrogens, contraceptive agents, and ionizing radiation. The vast majority of breast carcinomas are adenocarcinomas (ductal or lobular). Breast carcinoma spreads by direct invasion, by the lymphatic route, and by the blood vessel route. The most common site of lymph node involvement is the axilla.
Lung Carcinoma definition: A carcinoma originating in the lung. Lung carcinomas usually arise from the epithelium that lines the bronchial tree (bronchogenic carcinomas), and are classified as small cell or non-small cell carcinomas. Non-small cell lung carcinomas are usually adenocarcinomas, squamous cell carcinomas, or large cell carcinomas. Metastatic carcinomas to the lung are also common, and can be difficult to distinguish from primary tumors.
Parathyroid Gland Carcinoma definition: A malignant tumor arising from the parenchymal cells of the parathyroid gland. It is associated with the symptoms of primary hyperparathyroidism, resulting from the excessive production of parathyroid hormone. Morphologically, the differential diagnosis from parathyroid gland adenoma may be difficult. A definitive diagnosis of carcinoma is made only in the presence of capsular invasion, vascular invasion, and/or perineural invasion. (NCI05)
colon cancer definition: A disease in which malignant (cancer) cells are found in the tissues of the colon.
Colon Carcinoma definition: A malignant tumor usually arising from the epithelium lining the large intestinal mucosa. Colon carcinoma is one of the most common malignancies in both males and females, and is especially common in North America and Europe. Grossly, most colon carcinomas are polypoid or ulcerating lesions. Microscopically, adenocarcinoma is the most frequently seen morphologic subtype. Prognosis depends on the stage of the disease (depth of invasion, metastasis to regional/distal lymph nodes or other anatomic sites). -- 2004
Gastric Carcinoma definition: A malignant epithelial tumor of the stomach mucosa. The vast majority of gastric carcinomas are adenocarcinomas, arising from the gastric glandular epithelium. --2002
Bladder Carcinoma definition: A carcinoma arising from the bladder epithelium. Approximately 90% of the bladder carcinomas are transitional cell carcinomas. The remainder are squamous cell carcinomas, adenocarcinomas and small cell neuroendocrine carcinomas.
nonmelanoma skin cancer definition: Skin cancer that arises in basal cells or squamous cells but not in melanocytes (pigment-producing cells of the skin).
Metastatic Carcinoma to the Bone definition: A carcinoma that has spread to the bone from another, primary anatomic site. Bone is one of the most frequent sites of metastatic carcinoma. Common sites of origin include lung, breast, and prostate. --2003
Appendix Carcinoma definition: A malignant epithelial neoplasm arising from the appendix. The vast majority of the cases are adenocarcinomas.
Pharyngeal Carcinoma definition: Carcinoma, predominantly squamous cell, arising from epithelial cells of the pharynx. -- 2004
Stage 0 Cervical Cancer definition: Stage 0 includes: (Tis, N0, M0). Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th ed.) - 2003
Penile Carcinoma definition: Tumors of the penis make up approximately 1% to 1.5% of cancers in the male population in the United States and Europe. Risk factors include: phimosis (narrowing of the foreskin or prepuce) and Human Papilloma Viruses. The majority of penile cancers are squamous cell carcinomas. The most frequent clinical presentation is an irregular mass in the glans of the penis. Treatment includes: surgical management, radiation therapy (external beam and brachytherapy). - 2002
Endocervical Carcinoma definition: An adenocarcinoma characterized by the presence of malignant glandular epithelium resembling the endocervical epithelium.
Ameloblastic Carcinoma definition: A rare, cytologically malignant ameloblastoma that may metastasize.
bilateral cancer definition: Cancer that occurs in both paired organs, such as both breasts or both ovaries.
Hypopharyngeal Carcinoma definition: Carcinoma, predominantly squamous cell, arising from epithelial cells of the hypopharynx. -- 2004
Renal Carcinoma definition: A carcinoma arising from the epithelium of the renal parenchyma (renal cell carcinoma) or the renal pelvis (renal pelvis carcinoma). The vast majority of renal cell carcinomas are adenocarcinomas. The vast majority of renal pelvis carcinomas are transitional cell carcinomas. Renal carcinomas usually affect middle aged and elderly adults. Hematuria, abdominal pain, and a palpable mass are common symptoms. -- 2004
Basaloid Carcinoma definition: A malignant epithelial neoplasm characterized by the presence of neoplastic cells with hyperchromatic nuclei, small amount of cytoplasm, and peripheral nuclear palisading.
Apocrine Gland Carcinoma definition: A carcinoma with apocrine differentiation arising from the sweat glands. It presents as single or multiple nodular lesions which may be ulcerated or hemorrhagic and is usually in the axilla and less often in the anogenital region. It grows in the dermis and infiltrates subcutaneous tissues. It is characterized by the presence of large cells with abundant eosinophilic cytoplasm and large often vesicular nuclei. Most cases are slow growing tumors and have a prolonged course.
Carcinoma, Hepatocellular definition: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
hepatoma definition: (HEP-a-toe-SEL-yoo-ler kar-sin-O-ma) A type of adenocarcinoma, the most common type of liver tumor.
hepatoma definition: (hep-a-TOE-ma) A liver tumor.
hepatocellular carcinoma definition: primary malignant neoplasm of epithelial liver cells; it ranges from a well-differentiated tumor with epithelial cells indistinguishable from normal hepatocytes to a poorly differentiated neoplasm; the cells may be uniform or markedly pleomorphic, or form giant cells; associations exist with chronic hepatitis B virus infection, some types of cirrhosis, and hepatitis C virus infection.
Hepatocellular Carcinoma definition: A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation.
Oropharyngeal Carcinoma definition: Carcinoma, predominantly squamous cell, arising from epithelial cells of the oropharynx. -- 2004
 
 
frFrench
carcinome definition: [1] karzinom
carcinome definition: Variété de cancer qui se développe à partir de l'épithélium.
 
itItalian
carcinoma definition: [1] das Karzinom
carcinoma definition: Carcinome