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Basement Membrane definition: A darkly stained mat-like EXTRACELLULAR MATRIX (ECM) that separates cell layers, such as EPITHELIUM from ENDOTHELIUM or a layer of CONNECTIVE TISSUE. The ECM layer that supports an overlying EPITHELIUM or ENDOTHELIUM is called basal lamina. Basement membrane (BM) can be formed by the fusion of either two adjacent basal laminae or a basal lamina with an adjacent reticular lamina of connective tissue. BM, composed mainly of TYPE IV COLLAGEN; glycoprotein LAMININ; and PROTEOGLYCAN, provides barriers as well as channels between interacting cell layers.
basement membrane definition: extracellular matrix characteristically found under epithelial cells.
basement membrane definition: A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers. [ISBN:0198547684]
Basement Membrane definition: Ubiquitous supportive tissue adjacent to epithelium and around smooth and striated muscle cells. This tissue contains intrinsic macromolecular components such as collagen, laminin, and sulfated proteoglycans. As seen by light microscopy one of its subdivisions is the basal (basement) lamina.
Connective Tissue definition: Tissue that supports and binds other tissues. It consists of CONNECTIVE TISSUE CELLS embedded in a large amount of EXTRACELLULAR MATRIX.
Connective tissue definition: Tissue which consists of fibroblasts, osteocytes or chondrocytes and intercellular matrix produced by these cells. Examples: bone (tissue), dense regular elastic tissue, areolar tissue, neuroglia, adipose tissue.
connective tissue definition: tissue that supports and binds other tissues; consists of connective tissue cells embedded in a large amount of extracellular matrix.
connective tissue definition: Supporting tissue that surrounds other tissues and organs. Specialized connective tissue includes bone, cartilage, blood, and fat.
Portion of connective tissue definition: Tissue which consists of fibroblasts, osteocytes or chondrocytes and intercellular matrix produced by these cells. Examples: bone (tissue), dense regular elastic tissue, areolar tissue, neuroglia, adipose tissue.
Connective Tissue definition: The supporting or framework tissue of the animal body, formed of fibrous and ground substance with more or less numerous cells of various kinds; it is derived from the mesenchyme, and this in turn from the mesoderm; the varieties of connective tissue are: areolar or loose; adipose; dense, regular or irregular, white fibrous; elastic; mucous; and lymphoid tissue; cartilage; and bone; the blood and lymph may be regarded as connective tissues the ground substance of which is a liquid.
Connective Tissue Cells definition: A group of cells that includes FIBROBLASTS, cartilage cells, ADIPOCYTES, smooth muscle cells, and bone cells.
connective tissue cell definition: group of cells that includes fibroblasts, cartilage cells, adipocytes, smooth muscle cells, and bone cells.
Connective and Soft Tissue Cell definition: A group of cells that includes fibroblasts, cartilage cells, adipocytes, smooth muscle cells, and bone cells. (MeSH)
Connective Tissue Diseases definition: A heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., collagen, elastin, or the mucopolysaccharides.
connective tissue disorder definition: deviation from or interruption of the normal structure or function of the connective tissue.
connective tissue disorder diagnosis definition: determination of diseases of the tissues that support or bind other tissues based on symptoms, medical history, risk factors, and clinical tests.
Mixed Connective Tissue Disease definition: A syndrome with overlapping clinical features of systemic lupus erythematosus, scleroderma, polymyositis, and Raynaud's phenomenon. The disease is differentially characterized by high serum titers of antibodies to ribonuclease-sensitive extractable (saline soluble) nuclear antigen and a "speckled" epidermal nuclear staining pattern on direct immunofluorescence.
Neoplasms, Connective Tissue definition: Neoplasms composed of connective tissue, including elastic, mucous, reticular, osseous, and cartilaginous tissue. The concept does not refer to neoplasms located in connective tissue.
connective tissue neoplasm definition: new abnormal connective tissue that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease; refers to neoplasms located in the connective tissue as well as those consisting of connective tissue.
basal lamina definition: A thin sheet of proteoglycans and glycoproteins, especially laminin, secreted by cells as an extracellular matrix. [ISBN:0198547684]
basal lamina definition: filamentous, ultramicroscopic layer that occurs at the base of epithelial cells and around muscle cells and nerve fibers; subdivision of basement membrane.
connective tissue growth factor definition: cysteine rich mitogen secreted by vascular endothelial cells.
Connective Tissue Growth Factor Protein definition: Connective tissue growth factor protein (349 aa, ~38kDa) is encoded by the human CTGF gene. This protein plays a role in the promotion of proliferation and differentiation of chondrocytes and also mediates heparin- and divalent cation-dependent cell adhesion in many different cell types. The protein has also been found to inhibit the metastatic activity of human lung cancer in mice by angiogenisis inhibition.
Connective Tissue Growth Factor definition: A CCN protein family member that regulates a variety of extracellular functions including CELL ADHESION; CELL MIGRATION; and EXTRACELLULAR MATRIX synthesis. It is found in hypertrophic CHONDROCYTES where it may play a role in CHONDROGENESIS and endochondral ossification.
Neoplasms, Connective and Soft Tissue definition: Neoplasms developing from some structure of the connective and subcutaneous tissue. The concept does not refer to neoplasms located in connective or soft tissue.
Connective and Soft Tissue Neoplasm definition: A benign or malignant, primary or metastatic tumor affecting soft tissues or bone. Representative examples include mesenchymal cell neoplasms, metastatic carcinomas to the bones, and primary neoplasms of uncertain histogenesis.
Dense regular collagenous tissue definition: Regular connective tissue, the intercellular matrix of which consists predominantly of collagen fiber bundles arranged in parallel arrays.
Dense regular collagenous tissue definition: Regular connective tissue, the intercellular matrix of which consists predominantly of collagen fiber bundles arranged in parallel arrays.
Regular Dense Connective Tissue definition: Connective tissue mainly composed of parallel collagenous fibers leaving little room for embedded fibroblasts. This tissue has high tensile strength, but elasticity and flexibility are limited. Examples are tendons, ligaments and the fasciae and aponeuroses of muscles.
Areolar connective tissue definition: Loose connective tissue located at the outer and inner layers of organs. Examples: submucosal connective tissue, tunica adventitia of artery, papillary dermis, superficial fascia of dorsum of hand.
Areolar connective tissue definition: Loose connective tissue located at the outer and inner layers of organs. Examples: submucosal connective tissue, tunica adventitia of artery, papillary dermis, superficial fascia of dorsum of hand.
Dense regular elastic tissue definition: Regular connective tissue, which consists of fibroblasts and of intercellular matrix, which contains elastic fiber bundles oriented predominantly in definable directions.
Dense regular elastic tissue definition: Regular connective tissue, which consists of fibroblasts and of intercellular matrix, which contains elastic fiber bundles oriented predominantly in definable directions.
connective tissue disorder chemotherapy definition: application of the beneficial effects of drugs to control or cure diseases of tissues that support and bind other tissues.
connective tissue hyperplasia definition: abnormal increase in the number of otherwise normal cells in connective tissue without tumor formation that leads to enlargement of the connective tissue; it differs from hypertrophy, which is an increase in bulk without an increase in the number of cells.
connective tissue metabolism definition: sum of chemical changes that occur within the connective tissues consisting of anabolism (biosynthesis) and catabolism; the buildup and breakdown of molecules for utilization by the connective tissues.
connective tissue pharmacology definition: study of the origin, nature, properties, and actions of drugs and their effects on connective tissue; use this term mainly for intended, desired effects.
connective tissue stroma definition: supporting tissue or matrix of an organ as distinguished from its functional elements.
Dense irregular connective tissue definition: Irregular connective tissue is an irregular connective tissue, the intercellular matrix of which contains a dense irregular network of collagen and elastic fiber bundles. Examples: connective tissue of peritoneum, connective tissue of fibrous pericardium.
Dense irregular connective tissue definition: Irregular connective tissue is an irregular connective tissue, the intercellular matrix of which contains a dense irregular network of collagen and elastic fiber bundles. Examples: connective tissue of peritoneum, connective tissue of fibrous pericardium.
Irregular Dense Connective Tissue definition: Tissue characterized by a thick, random arrangement of collagen and elastin fibers with very few cells. The majority of the cells are fibroblasts, but mast cells and macrophages may also be seen. It is found in the dermis, periosteum, perichondrium, capsules of organs and sheaths of nerves and muscles.
connective tissue disorder therapy definition: therapies alone or in any combination, such as relaxation, exercise, massage, ultrasound, surgery, or alternative medicine; for drug therapies use CONNECTIVE TISSUE DISORDER CHEMOTHERAPY.
Sarcoma definition: A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.
sarcoma definition: any of a group of tumors usually arising from connective tissue, although the term now includes some of epithelial origin; most are malignant.
Sarcoma definition: A usually aggressive malignant mesenchymal cell tumor most commonly arising from muscle, fat, fibrous tissue, bone, cartilage, and blood vessels. Sarcomas occur in both children and adults. The prognosis depends largely on the degree of differentiation (grade) of the tumor. Representative subtypes are liposarcoma, leiomyosarcoma, osteosarcoma, and chondrosarcoma.
sarcoma definition: A cancer of the bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue.
Malignant Soft Tissue Neoplasm definition: A malignant mesenchymal neoplasm arising exclusively from the soft tissues. Representative examples include soft tissue sarcoma, extraosseous Ewing sarcoma/peripheral primitive neuroectodermal tumor, and malignant hemangiopericytoma.
MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS definition: Any deviation from the normal structure or function of the musculoskeletal or connective tissue that is manifested by a characteristic set of symptoms and signs. (NCI)
Connective and Soft Tissue Disorder definition: Any deviation from the normal structure or function of the musculoskeletal or connective tissue that is manifested by a characteristic set of symptoms and signs.
Connective Tissue Alteration definition: Connective Tissue Alteration involves a qualitative change in the existing state of supporting tissue derived from mesenchyme that binds other tissues and consists of various cell types embedded in a fibrous and ground substance extracellular matrix.
CTGF Gene definition: This gene is involved in mitogenesis.
Bone and Connective Tissue Pathology definition: The branch of pathology that focuses the causes and nature and effects of diseases of the bone and connective tissues.
Connective and Soft Tissue definition: The supporting connective tissue of an organ.
Deep Connective Tissue Fibrosis definition: Fibrotic degeneration of the deep connective tissues.