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Conserved Sequence definition: A sequence of amino acids in a polypeptide or of nucleotides in DNA or RNA that is similar across multiple species. A known set of conserved sequences is represented by a CONSENSUS SEQUENCE. AMINO ACID MOTIFS are often composed of conserved sequences.
Ribosomal Protein L13 definition: Encoded by human RPL13 Gene (L13E Ribosomal Protein Family), highly conserved 210-amino acid 24 kD cytoplasmic Ribosomal Protein L13 is a ribosomal 60S subunit protein. The protein is highly basic with no signal or transmembrane sequence, but has two potential nuclear localization signals. Ribosomes consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately eighty structurally distinct proteins. (from Swiss-Prot, OMIM, and NCI)
Conserved Helix-Loop-Helix Ubiquitous Kinase definition: Widely expressed by human CHUK Gene (Ser/Thr IKBK Family), 745-aa 85-kDa Conserved Helix-Loop-Helix Ubiquitous Kinase is an autophosphorylated cytoplasmic protein found in active heterodimer with IKK-beta bound to MAP3K14/NIK, MEKK1, IKAP, IKB-alpha-p65-p50 complex, and in complex with NCOA2, NCOA3, IKKB, IKBKG, and CREBBP. CHUK may interact with TRAF2, IKK-gamma/NEMO, and TRPC4AP. Inactivated by PP2A and activated by MAP3K14/NIK, AKT, and MEKK1, CHUK (or IKBKB) serine phosphorylates NFKB inhibitors (I-Kappa-Bs, NFKBIA or NFKBIB) leading to dissociation from cytoplasmically-trapped NFKB and ubiquitinated inhibitor degradation. Activated NFKB translocates to the nucleus, binds at kappa-B DNA binding motifs, and regulates transcription of target genes. CHUK also phosphorylates NCOA3. (NCI)
RPL13 Gene definition: This gene plays a role in transcription of ribosomal RNA which plays a role in protein synthesis.
CHUK Gene definition: This gene plays a role in signal transduction and regulation of transcription.
CTDSP2 Gene definition: This gene plays a role in the transcription and processing of pre-mRNA.
DAG/PE-Binding Domain definition: The cysteine-rich N-terminal DAG/PE (Diacylglycerol/Phorbol Ester)-Binding (C1) Domain of PKC isoforms interacts with phorbol ester or with the phospholipid-derived second messenger diacylglycerol. C1 contains one or two copies of a Cys-rich domain about 50 amino-acid residues long; the domain binds two zinc ions, probably involving the conserved cysteines and histidines. Bound to DAG, C1 domains are involved in recruitment of proteins to the membrane via basic residues that interact with lipid head groups. Part of the domain contains two beta sheets that form a cavity and a short C-terminal alpha helix; another contains two zinc-binding sites that maintain the domain fold. Binding of diacylglycerol, or phorbol ester, to the domain results in modification of protein function. (NCI)
CHUK wt Allele definition: Human CHUK wild-type allele is located within 10q24-q25 and is approximately 80 kb in length. This allele, which encodes inhibitor of nuclear factor kappa-B kinase subunit alpha protein, is involved in the progression of nuclear factor kappa B complex signaling.
RPL13 wt Allele definition: Human RPL13 wild-type allele is located in the vicinity of 16q24.3 and is approximately 4 kb in length. This allele, which encodes 60S ribosomal protein L13, is involved in the modulation of messenger RNA translation. Aberrant expression of the gene is linked to benign breast cancer.
Golgi transport complex definition: A complex of proteins that, in vitro, stimulates intra-Golgi transport; a 13S complex, about 800 kDa in size and consists of at least five polypeptides. In yeast, this complex is called the Sec34/35 complex and is composed of eight subunits (Sec34p, Sec35p, Dor1p, Cod1p, Cod2p, Cod3p, Cod4p, and Cod5p). [GOC:krc, PMID:9792665]