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17-Hydroxysteroid Dehydrogenases definition: A class of enzymes that catalyzes the oxidation of 17-hydroxysteroids to 17-ketosteroids. EC 1.1.-.
3-Hydroxysteroid Dehydrogenases definition: Catalyze the oxidation of 3-hydroxysteroids to 3-ketosteroids.
Acetoin Dehydrogenase definition: An enzyme that catalyzes the conversion of acetoin to diacetyl in the presence of NAD. EC 1.1.1.5.
Alcohol Dehydrogenase definition: A zinc-containing enzyme which oxidizes primary and secondary alcohols or hemiacetals in the presence of NAD. In alcoholic fermentation, it catalyzes the final step of reducing an aldehyde to an alcohol in the presence of NADH and hydrogen.
alcohol dehydrogenase definition: also another name for EC 1.1.1.21, ALDEHYDE REDUCTASE, do not confuse.
Alcohol Dehydrogenase definition: Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products.
Aldehyde Dehydrogenase definition: An enzyme that oxidizes an aldehyde in the presence of NAD+ and water to an acid and NADH. This enzyme was formerly classified as EC 1.1.1.70.
Ascorbate Oxidase definition: An enzyme that converts ascorbic acid to dehydroascorbic acid. EC 1.10.3.3.
oxoglutarate dehydrogenase definition: component of a multi-enzyme complex which decarboxylates alpha ketoglutarate to form succinyl coA in the Krebs' cycle.
Oxidoreductases definition: The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)
oxidoreductase definition: catalyses oxidation/reduction reactions.
Oxidoreductase definition: The class of all enzymes catalyzing oxidoreduction reactions (EC class 1). The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor: acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)
Phosphogluconate Dehydrogenase definition: An enzyme of the oxidoreductase class that catalyzes the reaction 6-phospho-D-gluconate and NADP+ to yield D-ribulose 5-phosphate, carbon dioxide, and NADPH. The reaction is a step in the pentose phosphate pathway of glucose metabolism. (From Dorland, 27th ed) EC 1.1.1.43.
1-Pyrroline-5-Carboxylate Dehydrogenase definition: An enzyme that catalyzes the oxidation of 1-pyrroline-5-carboxylate to L-GLUTAMATE in the presence of NAD. Defects in the enzyme are the cause of hyperprolinemia II.
11-beta-Hydroxysteroid Dehydrogenases definition: Hydroxysteroid dehydrogenases that catalyzes the reversible conversion of CORTISOL to the inactive metabolite CORTISONE. Enzymes in this class can utilize either NAD or NADP as cofactors.
15-Hydroxyprostaglandin Dehydrogenase [NAD+] definition: 15-hydroxyprostaglandin dehydrogenase [NAD+] (266 aa, ~29 kDa) is encoded by the human HPGD gene. This protein is involved in prostaglandin metabolism.
2-Oxoisovalerate Dehydrogenase (Acylating) definition: An NAD+ dependent enzyme that catalyzes the oxidation 3-methyl-2-oxobutanoate to 2-methylpropanoyl-CoA. It plays a role in the degradation of VALINE; LEUCINE; and ISOLEUCINE.
3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide) definition: A ketone oxidoreductase that catalyzes the overall conversion of alpha-keto acids to ACYL-CoA and CO2. The enzyme requires THIAMINE DIPHOSPHATE as a cofactor. Defects in genes that code for subunits of the enzyme are a cause of MAPLE SYRUP URINE DISEASE. The enzyme was formerly classified as EC 1.2.4.3.
3-Isopropylmalate Dehydrogenase definition: An NAD+ dependent enzyme that catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate to 3-carboxy-4-methyl-2-oxopentanoate. It is involved in the biosynthesis of VALINE; LEUCINE; and ISOLEUCINE.
Alanine Dehydrogenase definition: An NAD-dependent enzyme that catalyzes the reversible DEAMINATION of L-ALANINE to PYRUVATE and AMMONIA. The enzyme is needed for growth when ALANINE is the sole CARBON or NITROGEN source. It may also play a role in CELL WALL synthesis because L-ALANINE is an important constituent of the PEPTIDOGLYCAN layer.
Phosphoglycerate Dehydrogenase definition: An enzyme that catalyzes the oxidation of 3-phosphoglycerate to 3-phosphohydroxypyruvate. It takes part in the L-SERINE biosynthesis pathway.
Acyl-CoA Dehydrogenases definition: Enzymes that catalyze the first step in the beta-oxidation of FATTY ACIDS.
Aminomuconate-Semialdehyde Dehydrogenase definition: An NAD+ dependent enzyme that catalyzes the oxidation of 2-aminomuconate 6-semialdehyde to 2-aminomuconate.
11-beta-hydroxysteroid dehydrogenase activity definition: Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD(P)+ = an 11-oxosteroid + NAD(P)H + H+. [EC:1.1.1.146, PMID:15761036]
3(or 17)beta-hydroxysteroid dehydrogenase activity definition: Catalysis of the reaction: testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H + H+. [EC:1.1.1.51]
20-alpha-hydroxysteroid dehydrogenase activity definition: Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone. [EC:1.1.1.149, MetaCyc:1.1.1.149-RXN]
2-hydroxymethylglutarate dehydrogenase definition: Catalysis of the reaction: (S)-2-hydroxymethylglutarate + NAD+ = 2-formylglutarate + NADH + H+. [EC:1.1.1.291]