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Definition
 
enEnglish
Eligibility Determination definition: Criteria to determine eligibility of patients for medical care programs and services.
Eligibility Determination definition: The act of determining if a subject is suitable for enrollment in a study according specific protocol criteria and procedures.
Gastric Acidity Determination definition: Gastric analysis for determination of free acid or total acid.
Reagents, Immunoassay, Protein, Alpha-1-Antitrypsin definition: Immunoassay reagents intended to perform qualitative and/or quantitative analyses of body fluids (e.g., serum) to determine the presence of protein alpha-1 Antitrypsin (AAT), also known as protease inhibitor. AAT is a plasma protein that acts as the major inhibitor of trypsin and other proteolytic enzymes. Its concentration rises significantly during acute inflammatory processes (i.e., it is an acute-phase reactant), including surgery, myocardial infarction, infections, and/or in the presence of tumors. Increased levels of AAT typically occur within 24 hours of the injury and decrease in 4 or 5 days. Reduced levels or the absence of AAT is associated with increased risk of emphysema, especially in children.
Reagents, Immunoassay, Protein, Alpha-2-Macroglobulin definition: Immunoassay reagents intended to perform qualitative and/or quantitative analyses of body fluids (typically plasma) to determine the protein alpha-2 macroglobulin (A2MG), a high-molecular-weight protein whose major function is maintaining oncotic pressure during protein loss and that inhibits protease in a different way than other inhibitors. A2MG inhibits a wide variety of enzymes, including trypsin, plasmin, thrombin, and elastase. Increased levels of A2MG in blood (hyperglobulinemia) are seen in nephrotic syndrome.
Protein Sequencing definition: The process of determining the sequence of amino acids within a protein molecule.
Endpoint Determination definition: Establishment of the level of a quantifiable effect indicative of a biologic process. The evaluation is frequently to detect the degree of toxic or therapeutic effect.
Reagents, Clinical Chemistry, Enzyme, 5'-Nucleotidase definition: Clinical chemistry reagents intended to perform qualitative and/or quantitative chemical analyses of body fluids (typically serum) to determine the level of the enzyme 5'ribonucleotide phosphohydrolase (abbreviated as 5'NT or NTP). NTP activity is increased two- to sixfold in hepatobiliary diseases in which there is interference with the secretion of bile, as occurs when the bile duct is obstructed by stones or tumors or with biliary cirrhosis.
Reagents, Clinical Chemistry, Enzyme, Alanine Transferase definition: Clinical chemistry reagents intended to perform qualitative and/or quantitative chemical analyses of body fluids (typically serum) to determine the level of the enzyme alanine transferase (ALT), also known as alanine aminotransferase. ALT in serum is typically increased in liver diseases associated with hepatic necrosis, such as viral hepatitis and infectious mononucleosis with involvement of the liver.
Reagents, Clinical Chemistry, Enzyme, Aldolase definition: Clinical chemistry reagents intended to perform qualitative and/or quantitative chemical analyses of body fluids (typically serum) to determine the level of the enzyme aldolase (ALD). Aldolase in serum increases in a variety of diseases, but the assays are mostly performed to determine primary diseases of skeletal muscle (e.g., Duchenne muscular dystrophy).
Reagents, Clinical Chemistry, Enzyme, Amylase definition: Clinical chemistry reagents intended to perform qualitative and/or quantitative chemical analyses of body fluids (e.g., serum, urine, pleural fluid) to determine the level of the enzyme amylase. Amylase levels are transiently raised in acute pancreatitis, both in serum and in urine; they are also used to assess the development of complications (e.g., ascites, pleural effusion) following acute pancreatitis and in other diseases (e.g., some tumors of the lungs).
Reagents, Cytology/Histology, Antisera definition: Immunoassay reagents that include serum containing one or more antibodies. Serum containing several antibodies specific for more than one antigen or antigenic epitope is termed polyclonal antiserum; serum that contains only one type of antibody specific for one antigen or antigenic epitope is known as monoclonal antiserum.
Reagents, Cytology/Histology, Antisera, Monovalent definition: Immunoassay reagents that include antibodies specific for one antigen or antigenic epitope (i.e., monovalent antisera). They are usually the result of a single clone or plasma cell line and are typically produced as the secretion of hybrid cells formed by the fusion of lymphocytes and tumor cells (i.e., hybridomas) in a laboratory culture. Monovalent antisera are frequently used in cell typing.
Reagents, Immunoassay, Anemia Test definition: Reagents, Immunoassay, Anemia Test: Immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (e.g., serum, plasma, urine) to determine one or more of a group of substances present in the blood (e.g., erythropoietin, serum ferritin, folate) whose levels are usually changed in individuals with decreased erythrocyte count and/or hemoglobin level (i.e., anemia).
Reagents, Immunoassay, Autoimmune, Connective Tissue, Antinuclear Antibody definition: Immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (e.g., serum) to determine antibodies directed against nuclear antigens (i.e., antinuclear antibodies [ANA]). Increased ANA circulating levels are associated with autoimmune connective-tissue diseases, such as systemic lupus erythematosus, scleroderma, and rheumatoid arthritis.
Reagents, Immunoassay, Renal Metabolism, Aldosterone definition: Immunoassay reagents intended to perform qualitative and/or quantitative analyses of a sample of body fluids (e.g., serum, urine) to determine the level of aldosterone, the major mineralocorticoid hormone secreted by the adrenal cortex; its secretion is stimulated by angiotensin II. Very high levels of aldosterone (i.e., aldosteronism) are associated with plasma volume expansion, hypertension, and edema; they may occur due to overproduction of aldosterone (e.g., adrenal adenoma) or secondary due to extra adrenal diseases such as nephrotic syndrome or congestive heart failure.
Reagents, Immunoassay, Vitamin, D Metabolite, 1,25-Dihydroxyvitamin D definition: Immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (e.g., serum) to determine 1,25-dihydroxyvitamin D, also known as 1,25-(OH)2-D, a metabolite of both vitamin D2 and D3. These assays are not designed to differentiate between D2 and D3 metabolites. Decreased levels of this metabolite are associated with renal failure, hypercalcemia, or malignancy and other diseases.
Reagents, Immunoassay, Vitamin, D Metabolite, 25-Hydroxyvitamin D definition: Immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (e.g., serum) to determine 25-hydroxyvitamin D (25-OH-D), a metabolite of both vitamin D2 and D3. These assays are not designed to differentiate between D2 and D3 metabolites; a large number of bone and mineral metabolism disorders are associated with abnormal levels of 25-OH-D, including hypocalcaemia and osteomalacia
Reagents, Cytology/Histology, Antisera, Polyvalent definition: Immunoassay reagents that include antibodies specific for two or more antigens or antigenic epitopes (i.e., polyvalent antisera). They are usually the result of the response of an animal host to immunogen administration. Polyvalent antisera are frequently used in immunoassays in the clinical laboratory, particularly in the determination of plasma protein concentrations.
Reagents, Immunohematology, Blood Grouping, ABO Typing definition: Immunohematology reagents used to characterize human blood in types A, B, AB, or O. There are two types of tests for ABO grouping: The forward grouping test in which cells from a person of an unknown group are reacted with known anti-A and anti-B sera and the reverse test (confirmatory) that involves testing the reaction of serum of the unknown type with cells of known A and B reactivity.
Reagents, Immunoassay, Fertility Hormone, 17-Hydroxyprogesterone definition: Immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (e.g., serum saliva, whole blood) to determine 17-hydroxyprogesterone, a precursor of cortisol and aldosterone. Determination of the levels of 17-hydroxyprogesterone are useful in the evaluation of women with infertility and/or excessive growth of terminal hair (hirsutism). Measurements in plasma are also used for the diagnosis and monitoring of therapy of congenital adrenal hyperplasia (CAH) in newborns.
Reagents, Immunoassay, Fertility Hormone, Androstenedione definition: Immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (typically serum) to determine androstenedione, an androgen mainly secreted by the adrenal glands that is an immediate precursor of testosterone. Androstenedione is a sex steroid vital for human reproduction. High levels of circulating androstenedione are found in diseases such as polycystic ovaries, congenital adrenal hyperplasia, and adrenal tumors.
Reagents, Hematology, Blood Collection, Anticoagulant definition: Hematology reagents used to prevent clotting of blood samples for laboratory analysis by inhibiting blood coagulation, they also maintain cell viability. Most of these anticoagulants act by making calcium unavailable for the clotting process; they include citrates, oxalates, and ethylene-diamine-tetraacetic-acid (EDTA). Heparin is also used for this purpose; it prevents clotting by inactivating thrombin and/or other coagulation factors. Anticoagulants are frequently available in tubes as an internal coating.
Reagents, Immunoassay, Toxicology, Antidepressant definition: Immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (e.g., serum) to determine one or more of a group of drugs that stimulates the mood of a depressed patient (i.e., antidepressants). The most frequently administered antidepressants contain three fused rings in their chemical structure (i.e., tricyclic antidepressants). They include amitryptiline, desipramine, doxepin, imipramine, and nortriptyline. Some tetracyclic drugs are also used as antidepressants. Reagents used to determine antidepressant concentration in blood differentiate therapeutic levels (typically very low) from toxic levels due to overdose. Tricyclic antidepressant concentration in serum is directly related to therapeutic response, with the exception of nortriptyline which has a specific therapeutic window (typically 50 to 150 nanograms/milliliter). The metabolism of tricyclic antidepressants, especially their hydroxylation, results in the formation of active metabolites, which contribute to both the therapeutic and the adverse effects of these compounds.
Reagents, Serology, Bacteria, Streptococcus Species, Antibody, Streptolysin definition: Serology reagents intended to detect antibodies to deoxyribonuclease streptolysin (both type S and O), an antigenic exotoxin produced mostly by certain strains of group A streptococci. These antibodies develop in response to or as the result of a preceding streptococcal infection and are associated with some autoimmune diseases such as rheumatic fever and Tourette's syndrome.
Reagents, Immunoassay, Protein, Alpha-1-Microglobulin definition: Immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (e.g., plasma, serum, urine, amniotic fluid) to determine the protein alpha-1-microglobulin (A1MG), a low-molecular-weight protein. Increased ratios of alpha-1-microglobulin/creatinine in urine are associated with kidney tubule and/or glomerular damage, especially in children. High levels of placental A1MG in the serum of pregnant woman may be considered an indicator of intrauterine diseases (e.g., intrauterine hypoxia).
Reagents, Immunoassay, Endocrine Hormone, Adrenocorticotropin definition: Immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (typically serum) to determine the endocrine hormone adrenocorticotropin (ACTH), also known as corticotropin. ACTH is secreted by the anterior lobe of the pituitary gland. Its concentration in plasma is usually very low following a circadian rhythm. Increased concentrations of ACTH are found in diseases such as congenital adrenal hyperplasia, Addison's disease, ACTH-secreting tumors, and hypoglycemia. Determination of the ACTH level is also useful in differentiating primary from secondary adrenal insufficiency.
Reagents, Immunoassay, Endocrine Hormone, Catecholamine, Epinephrine definition: Immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (typically serum or urine) to determine epinephrine (also known as adrenaline), a secondary amine hormone in the catecholamine group. Epinephrine is the major substance produced by the adrenal medulla, it is a potent stimulator of the nervous system and a powerful cardiac stimulant; epinephrine also influences metabolic processes. Increased epinephrine levels (most assays measure active, free epinephrine) are associated with thyroid hormone deficiency, low blood pressure, congestive heart failure, and arrhythmias. Measurements of epinephrine and its metabolites (e.g., urinary metanephrines, vanillylmandelic acid) are also used for diagnosis of some catecholamine- secreting tumors (e.g., pheochromocytoma).
Reagents, Immunoassay, Autoimmune, Rheumatism, Anti-RA33 Antibody definition: Immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (e.g., serum) to determine circulating antibodies directed toward the A2hnRNP core protein, known as anti-RA33 antibodies. Determination of anti-RA33 antibodies, combined with the determination of rheumatoid factor antibodies, may be used in the identification of patients at risk of erosive arthritis, especially those patients who suffer from systemic lupus erythematosus.
anterior region determination definition: Specification of the anterior (head and thoracic segments) of the embryo by the gap genes; exemplified in insects by the actions of hunchback gene product. [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
axis specification definition: The establishment, maintenance and elaboration of a pattern along a line or a point. [GOC:dph, GOC:go_curators, GOC:isa_complete]
determination of symmetry definition: The establishment of an organism's body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created. [GOC:go_curators]
female germ-line sex determination definition: The determination of sex and sexual phenotype in a female organism's germ line. [GOC:mah]
Genotyping definition: The process of assessing genetic variation present in an individual.
determination of affect definition: Any process by which an emotional response is associated with a particular sensory stimulation. [GOC:ai, GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
sex determination definition: mechanism in a given species, by which the gender of an individual is fixed; in many species, gender is established at fertilization by the sperm that fertilizes the egg.
sex determination definition: Any process that establishes and transmits the specification of sexual status of an individual organism. [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
polyphenic determination definition: The process by which individuals that have the potential to develop any of several possible distinct developmental paths have their individual developmental fates determined in response to environmental and/or genetic cues. [GOC:jic]
caste determination definition: The process by which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to environmental and/or genetic cues. Individuals with distinct developmental fates perform different functions in a colony of social insects. [GOC:jic]
determination definition: Décision.
determination definition: Acharnement.
 
 
deGerman
Bestimmung definition: [1] ohne Plural: der Vorgang des Bestimmens [2] Anordnung, Vorschrift [3] ohne Plural: Verwendungszweck [4] Zielort eines Reisenden oder einer Warensendung [5] ohne Plural: das, was schon vorbestimmt ist; Schicksal, Berufung [6] wissenschaftliche Ermittlung, zum Beispiel von Pflanzen, von chemischen Zusammensetzungen etc [7] Grammatik: Satzteil, der einen Umstand angibt
Determination definition: [1] allgemein: Bestimmtheit, Bestimmung [2] Linguistik: nähere Bestimmung einer sprachlichen Einheit durch eine andere [3] Linguistik, speziell Glossematik: einseitige Abhängigkeitsrelation Luois Hjelmslev: Prolegomena zu einer Sprachtheorie. Hueber, München 1974, S. 29. ISBN 3-19-00.6709-0 [4] Philosophie: Angabe von Merkmalen, die einem Gegenstand, der bestimmt (determiniert) werden soll, zukommen
 
itItalian
determinazione definition: [1] die Bestimmung [2] die Festlegung [3] figürlich: die Entschlossenheit, die Bestimmtheit
 
frFrench
décision definition: [1] der Vorgang der Entscheidung oder der Entschließung [2] das Ergebnis der Entscheidung oder der Entschließung [3] die Kraft oder Fähigkeit, rasch (endgültige) Entscheidungen zu treffen [4] die Entscheidung eines Tribunals oder einer Behörde
orbitographie definition: Détermination et représentation des caractéristiques orbitales d’un satellite artificiel.
trajectographie definition: Détermination et représentation, immédiate ou différée, de la trajectoire d'un véhicule aérospatial à partir des données obtenues en cours de poursuite.
acharnement definition: Action d’un animal qui s’attache opiniâtrement à sa proie.
acharnement definition: Fureur opiniâtre avec laquelle des animaux, ou des hommes, se battent les uns contre les autres.
acharnement definition: Animosité opiniâtre qu’on a contre quelqu’un.
décision definition: Action de décider ou résultat de cette action.
décision definition: Qualité qui consiste à prendre promptement un parti et à s’y tenir avec fermeté.
détermination definition: Action de déterminer, de délimiter avec précision, de caractériser sans ambiguïté, clairement.
détermination definition: Résolution qu’on prend après avoir balancé entre plusieurs partis.
détermination definition: Action par laquelle une chose, également susceptible de plusieurs qualités, de plusieurs manières d’être, est déterminée à recevoir l’une plutôt que l’autre.