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DNA-Directed DNA Polymerase definition: DNA-dependent DNA polymerases found in bacteria, animal and plant cells. During the replication process, these enzymes catalyze the addition of deoxyribonucleotide residues to the end of a DNA strand in the presence of DNA as template-primer. They also possess exonuclease activity and therefore function in DNA repair. EC
DNA Polymerase definition: Nucleotidyltransferases that catalyze the addition of deoxyribonucleotide residues to the end of a DNA. EC or EC
DNA-directed DNA Polymerase definition: Catalyses DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time. Cannot initiate a chain de novo. Requires a primer, which may be DNA or RNA. (IUBMB Enzyme Nomenclature)
Immunotherapy definition: Manipulation of the host's immune system in treatment of disease. It includes both active and passive immunization as well as immunosuppressive therapy to prevent graft rejection.
immunotherapy definition: use of immunologic agents to therapeutically enhance or suppress the immune system; includes immunization, vaccines, artificial immunosuppression, treatment with cytokines or immunoconjugates, and lymphocyte deletion therapy; in addition also index the specific disorder therapy and immunologic agent used.
immunotherapy definition: (IM-yoo-no-THER-a-pee) Treatment to stimulate or restore the ability of the immune system to fight infections and other diseases. Also used to lessen side effects that may be caused by some cancer treatments.
Immunotherapy definition: Therapy designed to induce changes in a patient's immune status in order to treat disease.
RNA-Directed DNA Polymerase definition: An enzyme that synthesizes DNA on an RNA template. It is encoded by the pol gene of retroviruses and by certain retrovirus-like elements. EC
Reverse Transcriptase definition: RNA-dependent DNA polymerase. Enzyme involved in the replication of retroviruses, synthesizing a DNA viral intermediate that is then integrated into the host genome as a provirus.
DNA-Directed RNA Polymerases definition: Enzymes that catalyze DNA template-directed extension of the 3'-end of an RNA strand one nucleotide at a time. They can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesized. (From Enzyme Nomenclature, 1992).
RNA Polymerase definition: RNA polymerases comprise a group of enzymes that catalyze extension, one nucleotide at a time, of the 3 prime-end of an RNA strand along a complementary DNA template.
DNA-directed RNA Polymerase definition: Enzymes that catalyze the template-directed stepwise addition of ribonucleotides to the 3' end of a growing RNA chain using a single-stranded DNA template. The reaction is important in the flow of information from DNA to proteins. Three different forms of the polymerase have been identified and characterized.
Directed Tissue Donation definition: Tissue, organ, or gamete donation intended for a designated recipient.
Mutagenesis, Site-Directed definition: Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.
site directed mutagenesis definition: mutagenesis where the mutation is caused by in vitro induction directed at a specific site in a DNA molecule; the most common method involves use of a chemically synthesized oligonucleotide mutant which can hybridize with the DNA target molecule; the resulting mismatch-carrying DNA duplex may then be transfected into a bacterial cell line and the mutant strands recovered.
Targeted Mutation definition: A mutation created in a gene at a specific location.
Site-Directed Mutagenesis definition: Any of several methods used to create alterations in a gene at a specific location.
Proline-Directed Protein Kinases definition: A subclass of protein serine-threonine kinases that phosphorylate proteins on a SERINE or THREONINE residue that is immediately preceding a PROLINE residue.
in vitro Sensitivity-Directed Chemotherapy definition: Uses the results of a chemosensitivity testing assay to tailor the treatment to the individual.
Directed Molecular Evolution definition: The techniques used to produce molecules exhibiting properties that conform to the demands of the experimenter. These techniques combine methods of generating structural changes with methods of selection. They are also used to examine proposed mechanisms of evolution under in vitro selection conditions.
CATHETER, FLOW DIRECTED definition: A flow-directed catheter is a device that incorporates a gas-filled balloon to help direct the catheter to the desired position.
directed evolution definition: molecular diversity created by random mutagenesis and/or recombination of a target molecule or a family of related molecules; variants are then identified in a screen (or selection) that accurately reflects the properties of interest; molecules selected from these screens are used as parents for the next round of evolution; evolutionary methods are used to improve or alter enzymatic properties, as well as other biomolecular properties.
Directed Organ Donation definition: Organ donation intended for a designated recipient.
Directed Gamete Donation definition: Gamete donation intended for a designated recipient.
taxis definition: The directed movement of a motile cell or organism in response to an external stimulus. [GOC:jl, ISBN:0192801023]
POLB Gene definition: This gene is involved in DNA repair necessary for DNA maintenance, replication, recombination, and drug resistance.
use as directed definition: Drug is to be used as directed by the prescriber.
Directed Acyclic Graph definition: A graph whose edges are ordered pairs of vertices or nodes and which contains no path that starts and ends at the same vertex.