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intervertebral disk definition: plates of fibrocartilage found between the bodies of adjacent vertebrae in the spine, each consisting of a fibrous ring enclosing a pulpy center.
Intervertebral Disc definition: Spongy discs located between the vertebrae of the spinal column; composed of the outer annulus fibrosus and inner nucleus pulposus.
Papilledema definition: Swelling of the OPTIC DISK, usually in association with increased intracranial pressure, characterized by hyperemia, blurring of the disk margins, microhemorrhages, blind spot enlargement, and engorgement of retinal veins. Chronic papilledema may cause OPTIC ATROPHY and visual loss. (Miller et al., Clinical Neuro-Ophthalmology, 4th ed, p175)
papilledema definition: swelling of the optic disk, usually in association with increased intracranial pressure, characterized by hyperemia, blurring of the disk margins, microhemorrhages, blind spot enlargement, and engorgement of retinal veins.
papilledema definition: (pap-il-eh-DEE-ma) Swelling around the optic disk, the area where the optic nerve (the nerve that carries messages from the eye to the brain) enters the eyeball. Papilledema occurs when increased brain pressure caused by tumors or other problems results in swelling of the optic nerve.
Papilledema definition: Swelling around the optic nerve, usually due to increased intracranial pressure or pressure on the nerve by a tumor.
Compact Disks definition: Computer disks storing data with a maximum reduction of space and bandwidth. The compact size reduces cost of transmission and storage.
SUSCEPTIBILITY TEST DISCS, ANTIMICROBIAL definition: An antimicrobial susceptibility test disc is a device that consists of antimicrobic-impregnated paper discs used to measure by a disc-agar diffusion technique or a disc-broth elution technique the in vitro susceptibility of most clinically important bacterial pathogens to antimicrobial agents. In the disc-agar diffusion technique, bacterial susceptibility is ascertained by directly measuring the magnitude of a zone of bacterial inhibition around the disc on an agar surface. The disc-broth elution technique is associated with an automated rapid susceptibility test system and employs a fluid medium in which susceptibility is ascertained by photometrically measuring changes in bacterial growth resulting when antimicrobial material is eluted from the disc into the fluid medium. Test results are used to determine the antimicrobial agent of choice in the treatment of bacterial diseases.
Antimicrobial Reagent Disks definition: Small, round, thin patches impregnated with an antimicrobial substance (i.e., a substance known to kill or inhibit the growth of one or more microorganisms) that are intended to be used to measure (e.g., by a disk-agar diffusion technique or a disk-broth elution technique) the in vitro susceptibility of most clinically important bacterial pathogens to antimicrobial agents. These disks are typically used in the identification of bacteria.
DISK, ABRASIVE definition: An abrasive device and accessories is a device constructed of various abrasives, such as diamond chips, that are glued to shellac-based paper. The device is intended to remove excessive restorative materials, such as gold, and to smooth rough surfaces from oral restorations, such as crowns. The device is attached to a shank that is held by a handpiece. The device includes the abrasive disk, guard for an abrasive disk, abrasive point, polishing agent strip, and polishing wheel.
Dental Disks, Abrasive definition: Circular plates that have abrasive materials bonded to the surface and/or edge, either the inside (safe outside) or the outside (safe inside). Abrasive disks are used with straight or contra-angled handpieces for low revolutions in polishing and finishing a cavity preparation and for cutting or polishing dental restorations.
DISCS, STRIPS AND REAGENTS, MICROORGANISM DIFFERENTIATION definition: A microorganism differentiation and identification device is a device intended for medical purposes that consists of one or more components, such as differential culture media, biochemical reagents, and paper discs or paper strips impregnated with test reagents, that are usually contained in individual compartments and used to differentiate and identify selected microorganisms. The device aids in the diagnosis of disease.
DISCS, ELUTION definition: An antimicrobial susceptibility test disc is a device that consists of antimicrobic-impregnated paper discs used to measure by a disc-agar diffusion technique or a disc-broth elution technique the in vitro susceptibility of most clinically important bacterial pathogens to antimicrobial agents. In the disc-agar diffusion technique, bacterial susceptibility is ascertained by directly measuring the magnitude of a zone of bacterial inhibition around the disc on an agar surface. The disc-broth elution technique is associated with an automated rapid susceptibility test system and employs a fluid medium in which susceptibility is ascertained by photometrically measuring changes in bacterial growth resulting when antimicrobial material is eluted from the disc into the fluid medium. Test results are used to determine the antimicrobial agent of choice in the treatment of bacterial diseases.
Palmitoylated Membrane Protein 3 definition: Encoded by human MPP3 Gene (MAGUK Family), 585-aa 66-kDa Palmitoylated Membrane Protein 3 is suspected to play a role in signal transduction and contains 1 PDZ/DHR domain, a conserved SH3 domain, and 1 guanylate kinase-like domain. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. (NCI)
Presynaptic Density Protein 95 definition: Widely expressed by human DLG4 Gene (MAGUK Family), 767-aa 85-kD cytoplasmic Presynaptic Density Protein 95 (concentrated at presynaptic junctions), contains one SH3, one Guanylate Kinase-like, and three PDZ/DHR domains. It heteromultimerizes with DLG2, interacts with the cytoplasmic tail of NMDA receptor subunits, and, with DLG2, mediates NMDA and potassium channel clustering. PSD-95 also binds to KIF13B and interacts through a PDZ domain with NLGN1. DLG4 may form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. (NCI)
DISC definition: A circular plate-like organ or structure. (FDA)
Disc Dosage Form definition: The pharmaceutical dosage form of a flat, circular shape containing solid or powdered medicine, e.g. disk with powdered agent for inhalation, or transdermal disk.
Disk definition: A circular plate-like organ or structure.
DLG1 Gene definition: This gene plays a role in cellular communication and organization/biogenesis.
DLG4 Gene definition: This gene is involved in synaptic plasticity and transmission.
MPP2 Gene definition: This gene is involved in cytoskeletal modeling, cell proliferation and intercellular communication.
MPP3 Gene definition: This gene plays a role in cytoskeletal modeling, intercellular communication and cell proliferation.
Palmitoylated Membrane Protein 2 definition: Encoded by human MPP2 Gene (MAGUK Family), 576-aa 65-kDa Palmitoylated Membrane Protein 2 is suspected to play a role in signal transduction and contains 1 PDZ/DHR domain, a conserved SH3 domain, and 1 guanylate kinase-like domain. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. (NCI)
Presynaptic Protein SAP97 definition: Encoded by human DLG1 Gene (MAGUK Family), alternative isoforms 1 (904-aa) and 2 (926-aa) of 100-kD Presynaptic Protein SAP97 are a putative kinase that appears to regulate protein targeting and contains one SH3, one Guanylate Kinase-like, and three PDZ/DHR domains. DLG1 binds to membrane cytoskeletal protein 4.1 (EPB41) and to KIF13B, and interacts with the KCNAB1 channel as well as the cytoplasmic tail of NMDA receptor subunits. LCK interacts with the proline-rich N-terminal domain of DLG1. Interacting with actin-binding ezrin, SAP97 is also involved in cell shape morphogenesis. (NCI)
Blastodisc definition: A small whitish spot on the surface of the EGG YOLK where cleavage begins. Upon fertilization the cytoplasm streams from the vegetal pole away from the yolk to the animal pole where cleavage will occur. This germinal area eventually flattens into a layer of cells (BLASTODERM) that covers the yolk completely.