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Kringles definition: Triple-looped protein domains linked by disulfide bonds. These common structural domains, so-named for their resemblance to Danish pastries known as kringlers, play a role in binding membranes, proteins, and phospholipids as well as in regulating proteolysis. Kringles are also present in coagulation-related and fibrinolytic proteins and other plasma proteinases.
Kringle Domain definition: Kringles are autonomous structural domains, found throughout the blood clotting and fibrinolytic proteins. Kringle domains are believed to play a role in binding mediators (e.g., membranes, other proteins or phospholipids), and in the regulation of proteolytic activity. Kringle domains are characterised by a triple loop, 3-disulphide bridge structure, whose conformation is defined by a number of hydrogen bonds and small pieces of anti-parallel beta-sheet. They are found in a varying number of copies, in some serine proteases and plasma proteins.
Ankyrin Repeat definition: Protein motif that contains a 33-amino acid long sequence that often occurs in tandem arrays. This repeating sequence of 33-amino acids was discovered in ANKYRIN where it is involved in interaction with the anion exchanger (ANION EXCHANGE PROTEIN 1, ERYTHROCYTE). Ankyrin repeats cooperatively fold into domains that mediate molecular recognition via protein-protein interactions.
Ankyrin Repeat definition: Ankyrin Repeats are tandem modules of about 33 amino acids. The conserved domain structure has been described as side-by-side anti-parallel alpha helices connected by intervening beta hairpin motifs or as beta, alpha, alpha, beta secondary structures or as an L-shaped beta-hairpin and two alpha-helices. The repeats associate to form a higher order structure. Despite sequence variation, the domain core maintains a stable surface of contact residues to mediate protein-protein interactions. Target protein binding involves contacts by the beta hairpin tips and the helical bundle surface facing the Ankyrin groove. ANK repeats have been identified in over 1700 functionally diverse proteins, primarily from eukaryotes; no common theme among the protein targets has been identified. The Ankyrin cytoskeletal protein is composed almost entirely of these repeats.
Protein Structure, Tertiary definition: The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Tertiary Protein Structure definition: Tertiary structure describes the folding of the polypeptide chain to assemble the different secondary structure elements in a particular arrangement.
Helix-Loop-Helix Motifs definition: Recurring supersecondary structures characterized by 20 amino acids folding into two alpha helices connected by a non-helical "loop" segment. They are found in many sequence-specific DNA-BINDING PROTEINS and in CALCIUM-BINDING PROTEINS.
Helix-Loop-Helix Domain definition: In transcription regulators of cell cycle control, cell determination, and cell differentiation, the conserved HLH (Helix-Loop-Helix) Domain of 40-50 amino acids forms amphipathic helixes between a variable loop. HLHs typically mediate homo- or heterodimerization through interactions with self or other motifs to activate or inactivate trans-activating function. The N-helix often contains DNA-interacting basic residues; the C-helix typically contains characteristically spaced hydrophobic residues. An adjacent basic region of 15 amino acids in most HLH proteins binds to DNA. Basic (b)HLH proteins bind variants of the 'CANNTG' E-box. Proteins lacking the basic domain act as inhibitors, failing to bind DNA. bHLH proteins exhibit specific dimerization partner combinations. In calcium-binding proteins, certain invariant hydrophilic loop residues in the HLH motif bind calcium. (NCI)
ENVIRONMENTAL DOMAIN definition: Material resources and physical surroundings both inside and outside the living area, neighborhood, and broader community.
PSYCHOSOCIAL DOMAIN definition: Patterns of behavior, emotion, communication, relationships, and development.
PHYSIOLOGICAL DOMAIN definition: Functions and processes that maintain life.
Homeo Domain definition: The DNA-binding homeo domain was originally identified in transcription factor proteins encoded by homeobox genes (homeotic genes). The homeo domain is structurally similar to the helix-turn-helix DNA-binding domain of CRO and Lambda repressor.
Catalytic Domain definition: The region of an enzyme that interacts with its substrate to cause the enzymatic reaction.
HMG-Box Domains definition: DNA-binding domains present in proteins of the HMG-box superfamily including the archetypal HMGB PROTEINS, a number of sequence specific TRANSCRIPTION FACTORS, and other DNA-BINDING PROTEINS. The domains consist of 70-80 amino acids that form an L-shaped fold from three alpha-helical segments. The domain has the capacity to recognize and/or induce specific DNA structures and effect the accessibility of the DNA to other proteins involved in transcription, recombination, or DNA repair. (Note that not all HIGH MOBILITY GROUP PROTEINS contain this domain.)
AT-Hook Motifs definition: DNA-binding motifs, first described in one of the HMGA PROTEINS: HMG-I(Y) PROTEIN. They consist of positively charged sequences of nine amino acids centered on the invariant tripeptide glycine-arginine-proline. They act to fasten the protein to an AT RICH SEQUENCE in the DNA.
AT Hook Motif definition: Highly conserved peptide motifs of the HMG-I(Y) proteins that preferentially bind, in vivo and in vitro, to the narrow minor groove of stretches of AT-rich DNA. The AT Hook Motif tethers and unbends the minor groove of the DNA with very little specificity for the DNA sequence. The AT hook motif has a narrow DNA recognize surface which is devoid of hydrophobic amino acids and does not significantly distort the B-form DNA structure.
Bradyrhizobiaceae definition: A proposed family of bacteria belonging to the alpha-2 subgroup of PROTEOBACTERIA.
ATPase Domain definition: A protein domain that binds ATP and catalyzes its convertion to ADP and inorganic phosphate.
Armadillo Repeat definition: Identified in over 240 functionally diverse proteins from yeast to man, ARM Repeats are approximately 40-amino acids long and composed of two longer anti-parallel helices (H2 and H3) that follow a perpendicular short helix (H1). Tandem repeats form a right-handed superhelix (3 helixes per unit); tight repeat packing creates a cylindrical hydrophobic core throughout the structure. Lined by highly conserved residues, the positively charged groove of the superhelix appears to mediate interaction with acidic surfaces of target proteins. Despite amino acid variability, ARM repeat structures are highly conserved. Though involved in protein-protein interactions, no common features among target proteins have been identified. ARM repeats have a common phylogenetic origin with the HEAT repeat; both contain seven highly conserved hydrophobic residues.
BH1 Domain definition: Found in proteins that regulate apoptosis, conserved a-helix BCL-2 Homology (BH1-4) Domains are critical to protein apoptotic function and the protein ability to interact/dimerize with other family members or regulatory proteins. BH1 contains predominantly hydrophobic residues. BCL-2 family proteins dimerize among pro- and anti-apoptotic class family members. BCL-2 homodimerization appears to involve head-to-tail interaction of N-terminal BH4 resides with more distal BH1, BH2, and BH3 regions. BCL-2/BAX heterodimerization appears to involve tail-to-tail interaction of the BCL-2 BH1, BH2, and BH3 regions and the BAX BH3 domain region. BCL-2 may suppress cell death partly by binding to BAX via the BH3 domain preventing BAX homodimer formation. (NCI)
BH2 Domain definition: Found in proteins that regulate apoptosis, conserved a-helix BCL-2 Homology (BH1-4) Domains are critical to protein apoptotic function and the protein ability to interact/dimerize with other family members or regulatory proteins. BCL-2 family proteins dimerize among pro- and anti-apoptotic class family members. BCL-2 homodimerization appears to involve head-to-tail interaction of N-terminal BH4 resides with more distal BH1, BH2, and BH3 regions. BCL-2/BAX heterodimerization appears to involve tail-to-tail interaction of the BCL-2 BH1, BH2, and BH3 regions and the BAX BH3 domain region. BCL-2 may suppress cell death partly by binding to BAX via the BH3 domain preventing BAX homodimer formation. (NCI)
BH3 Domain definition: The alpha-helical BH3 domain (9 amino acids) represents a minimal death domain and is essential for the activity of pro-apoptotic members of the bcl-2 family. Some of these proteins only contain a BH3 domain.
BH4 Domain definition: BH4 is present only in the amino-terminal regions of pro-survival family bcl-2 members and is essential for the anti-apoptotic function, although deletion of BH4 does not necessarily impair the ability of BH4-containing proteins to bind to a variety of other bcl-2-related proteins.
BIR Domain definition: Containing perfectly conserved histidine and cysteines residues. the BIR domain is about 70 residues long arranged in tandem repeats separated by a linker of variable length. Found in IAP (Inhibitor of Apoptosis Protein) Family proteins, it seems to confer cell death-preventing activity. Except NAIP, family members typically contain two or three BIR repeats and a C-terminal RING finger. A second group of BIR-domain-containing proteins (BIRPs) include mammalian Bruce and Survivin proteins, as well as BIR-containing proteins in yeasts and C. elegans. Survivin-like BIRPs regulate cytokinesis and mitotic spindle formation. (NCI)
BRCT Domain definition: BRCT domain was first identified in C-terminal domain of breast cancer associated protein and was found in many proteins that regulate the cellular response to DNA repair, where these domains act as multi-purpose protein-protein interaction modules. Crystallography study reveals that two ~95 amino acid BRCT repeats within the domain adopt similar structures that pack together in a head-to-tail arrangement. (NCI)
BTB/POZ Domain definition: The BTB/POZ domain is an approximately 120 amino acid long, hydrophobic region found in two distinct classes of transcriptional regulators that contain either a C-terminal basic leucine zipper motif (POK proteins) or a Zn-finger region (Bach proteins). This domain has been shown to form homo-dimers in a number of BTB/POZ domain containing proteins. (NCI)
C2 Domain definition: Some isozymes of protein kinase C (PKC) contain a domain, known as C2, of about 116 amino-acid residues which is located between the two copies of the C1 domain (that bind phorbol esters and diacylglycerol) and the protein kinase catalytic domain. Regions with significant homology to the C2-domain have been found in many proteins. The C2 domain is thought to be involved in calcium-dependent phospholipid binding. Since domains related to the C2 domain are also found in proteins that do not bind calcium, other putative functions for the C2 domain such as binding to inositol-1,3,4,5-tetraphosphate have been suggested. The 3D structure of the C2 domain of synaptotagmin has been reported, the domain forms an eight-stranded sandwich constructed around a conserved 4-stranded motif, designated a C2 key. Calcium binds in a cup-shaped depression formed by the N- and C-terminal loops of the C2-key motif. (From Pfam 00168)
Cadherin Domain definition: Evolutionary related to desmosomal desmogleins, cadherins contain a signal sequence, a propeptide of around 130 residues, an extracellular domain of around 600 residues, a single transmembrane domain, and a well-conserved C-terminal cytoplasmic domain of about 150 residues. The extracellular domain typically consists of four Cadherin Domain repeats of about 110 residues; an adjacent fifth domain contains four conserved cysteines. The domain includes conserved Asp and Arg residues that may be involved in calcium binding. Tissue-specific cadherin glycoproteins are responsible for homophilic calcium-dependent cell-cell adhesion likely involved in cell type sorting during morphogenesis, histogenesis, and regeneration. They may also regulate tight and gap junctions. (NCI)
Cytoplasmic Domain definition: The part of a transmembrane protein which projects into the cytoplasm.
DAG/PE-Binding Domain definition: The cysteine-rich N-terminal DAG/PE (Diacylglycerol/Phorbol Ester)-Binding (C1) Domain of PKC isoforms interacts with phorbol ester or with the phospholipid-derived second messenger diacylglycerol. C1 contains one or two copies of a Cys-rich domain about 50 amino-acid residues long; the domain binds two zinc ions, probably involving the conserved cysteines and histidines. Bound to DAG, C1 domains are involved in recruitment of proteins to the membrane via basic residues that interact with lipid head groups. Part of the domain contains two beta sheets that form a cavity and a short C-terminal alpha helix; another contains two zinc-binding sites that maintain the domain fold. Binding of diacylglycerol, or phorbol ester, to the domain results in modification of protein function. (NCI)
DH Domain definition: The Dbl homology (DH) or RhoGEF domain consists of a 150 amino acid region that induces Rho family GTPases to displace GDP. This effectively activates the Rho GTPase by allowing binding to GTP, which is in excess over GDP in the cell. The DH domain is invariably proceeded by a pleckstrin homology (PH) domain. While not absolutely required for catalysis of nucleotide exchange, the PH domain appears to greatly increase catalytic efficiency in many cases. Rho proteins control actin dynamics, gene expression, membrane trafficking, growth factor signaling, and cellular transformation. Proteins encoding DH domains (RhoGEFs) also play a role in these events as they function as the primary activators of Rho GTPases. In fact, many RhoGEFs were identified based on their transforming activity, which was abrogated upon disruption of their DH domain. (Pawson Lab, SLRI, Mount Sinai Hospital, 2003)
DIX Domain definition: A domain involved in homo- and hetero-oligomerization.
Death Domain definition: The death domain is a protein region, approximately 80 amino acids long, that is required for transmission of the cytotoxic signal of apoptosis and is present in the TNF receptor, FAS, and several downstream signaling molecules. Transmission of the apoptotic signal requires the functional interaction of proteins via the death domain.
Disintegrin Domain definition: It is an integrin binding domain originally identified in ADAM family proteins. (NCI)
Double-Stranded RNA Binding Domain definition: The Double-Stranded RNA Binding Domain is found in a variety of RNA-binding proteins with different structures and exhibiting a diversity of functions. It is involved in localization of at least five different mRNAs in the early Drosophila embryo and by interferon-induced protein kinase in humans, which is part of the cellular response to dsRNA. (InterPro IPR001159)
ETS Domain definition: Usually C-terminal, the conserved ETS (Erythroblast Transformation Specific) Domain of 85-90 amino acids, rich in positively-charged and aromatic residues, binds to purine-rich DNA with a GGAA/T core. Identified in many transcription factors, many ETS-proteins modulate gene expression through protein-protein interactions with other transcriptional factors and co-factors. Most ETS-proteins are nuclear targets of RAS-MAPK signaling; some affect cell proliferation or apoptosis-related genes. Several are expressed in specific cell lineages to regulate development and differentiation. Deregulated ETS-gene expression or chimeric ETS-proteins are associated with leukemias, some tumors, invasion and metastasis. (NCI)
HMG-Box definition: The HMG-Box Domain binds to and bends the minor groove of the DNA. This domain can recognize and bind to altered DNA conformations, such as stem-loops, four-way junctions, and specifically kinked or underwound DNA. (Mol Cell Biol 1999 Aug;19(8):5237-46)
HMG Domain definition: Each HMG subfamily is a distinct set of proteins with identifiable structural characteristics and a specific type of targets to induce characteristic changes in the structure of its binding site.
Immunoglobulin Domain definition: The major histocompatibility complex (MHC) molecules are made of 2 chains, alpha and beta. In class I, the alpha chain is composed of 3 extracellular domains, a transmembrane region and a cytoplasmic tail while the beta chain is of a single extracellular domain. In class II, both the alpha and the beta chains are composed of 2 extracellular domains, a transmembrane region and a cytoplasmic tail. The immunoglobulin (Ig) constant chain domains and a single extracellular domain in each type of MHC chains are homologous and approximately one hundred amino acids long, and include a conserved intra-domain disulfide bond. Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions, e.g., antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions. (InterPro IPR007110)
N Domain definition: N Domain is one of the seven predicted immunoglobulin-like domains that members of the CEA family protein have. It is extremely hydrophobic. (From OMIM and NCI)
Protease Domain definition: The portion of a proteolytic protein which causes hydrolysis and cleavage of other protein polypeptides.
Protein Domain definition: A structurally or functionally defined protein region.
RHO Effector Domain definition: The REM repeat, which is also called rho effector or HR1 domain, was first described as a three times repeated homology region of the N-terminal non-catalytic part of protein kinase PRK1(PKN). The first two of these repeats were later shown to bind the small G protein rho known to activate PKN in its GTP-bound form. Similar rho-binding domains also occur in a number of other protein kinases and in the rho-binding proteins rhophilin and rhotekin. Recently, the structure of the N-terminal REM repeat complexed with RhoA has been determined by X-ray crystallography. It forms an antiparallel coiled-coil fold termed an ACC finger.
bHLH Domain definition: The bHLH domain is a bipartite DNA-binding domain containing a basic region upstream of an amphipathic helix-loop-helix region. The basic region interacts with DNA and the HLH motif mediates protein dimerization.
bZIP Domain definition: Bipartite DNA binding domain containing a basic region directly interacting with DNA, and a leucine zipper mediating dimerization through contacts with a protein partner.
ARID Domain definition: The approximately 100-amino acid ARID (AT-Rich Interaction Domain) DNA-binding domain occurs in some transcriptional regulators (and perhaps modifiers of chromatin structure) involved in embryonic development, cell lineage, and cell cycle control. The domain shows more diversity in structure and function than the highly conserved sequence suggests: at least six alpha helices separated by beta-strands, loops, or turns. Although Bright, dead ringer, and MRF-2 preferentially bind to AT-rich sites, DNA binding of ARID-proteins is not necessarily sequence specific; ARID protein p270 of the SWI-SNF complex exhibits non-specific DNA binding activity. ARID family proteins may be involved in a wide range of DNA interactions. Inappropriate expression of ARID proteins is increasingly implicated in tumorigenesis.
Conceptual Domain definition: The set of all possible Valid Value meanings of a Data Element Concept expressed without representation.
Extracellular Domain definition: Any part of a transmembrane protein that projects into the environment surrounding a cell.
FHA Domain definition: The FHA (Forkhead-Associated) domain is a phosphopeptide recognition domain found in many regulatory proteins. It displays specificity for phosphothreonine-containing epitopes but will also recognize phosphotyrosine with relatively high affinity. It spans approximately 80-100 amino acid residues folded into an 11-stranded sandwich, which sometimes contain small helical insertions between the loops connecting the strands. To date, genes encoding FHA-containing proteins have been identified in eubacterial and eukaryotic but not aracheal genomes. The domain is present in a diverse range of proteins, such as kinases, phosphatases, kinesins, transcription factors, RNA-binding proteins and metabolic enzymes which partake in many different cellular processes. DNA repair, signal transduction, vesicular transport and protein degradation are just a few examples.
Frizzled Domain definition: A 120 amino acid protein domain, with an alpha-helical structure, containing 10 cysteines, which have conserved spacing throughout the sequence. This domain is involved in the recognition of extracellular ligands.
KDEL Motif definition: A motif found at the C termini of several luminal proteins of the ER that serves to mediate the retention of resident proteins of the ER lumen through retrieval from post-ER compartments ER via a transport mechanism involving vesicular and tubular elements.
KH Domain definition: First identified in human hnRNPK protein, the conserved KH Domain of around 45-70 amino acids is present in a variety of nucleic acid-binding proteins. The domain may bind RNA in vivo. KH motifs are found in one or multiple copies, interspersed with RGG repeats, that may function cooperatively or, in single motif proteins, independently. KH domains can be separated into two groups: type-1 (beta-alpha-alpha-beta-beta-alpha) and type-2 (alpha-beta-beta-alpha-alpha-beta). The VIGXXGXXI sequence is preserved in the RNA binding motif between helix 1 and 2 (type-1) and helix 2 and 3 (type-2). The beta sheets are supported by alpha helixes. (NCI)
LIM Domain definition: The LIM domain is a zinc binding, cysteine rich motif consisting of two tandemly repeated zinc fingers. Unlike GATA type zinc fingers, LIM domains do not bind DNA but instead mediate protein-protein interactions. Functionally, LIM domain containing proteins have been implicated in cell lineage specification, cytoskeletal organization, and organ development.
PH Domain definition: Pleckstrin-homology (PH) domains are protein modules of approximately 120 amino acids found in a wide variety of signaling proteins in organisms ranging from yeast to humans. Some PH domains bind with high affinity (low mM or nM Kd) to specific phosphoinositides such as phosphatidyl-inositol (PI) -4,5-bisphosphate, PI-3,4-P2 or PI-3,4,5-P3. Binding to phosphoinositides may allow PH proteins to respond to lipid messengers for example by relocation to membranes. The C-termini of some PH domains have also been reported to bind the beta/lambda subunits of heterotrimeric G proteins.
POU Domain definition: The POU domain is a bipartite DNA binding domain recognized originally as a shared structural motif in the Pit-1, Oct-1/Oct-2, and Unc-86 transcription factors (POU). It is comprised by a C-terminal homeo domain, and an N-terminal POU-specific domain, separated by a non-conserved linker. The POU-specific domain, like the homeo domain, is folded in a helix-turn-helix motif.
PTB Domain definition: Phosphotyrosine binding (PTB) domains are 100-150 residue modules that commonly bind Asn-Pro-X-Tyr motifs. The PTB domains of the docking proteins Shc and IRS-1 require ligand phosphorylation on the tyrosine residue (NPXpY) for binding. More N-terminal sequences are also required for high affinity binding and conferring specificity. The peptide binds as a b-strand to an anti-parallel b-sheet, while the NPXpY motif makes a turn, positioning the pY for recognition by basic residues. The PTB domains of proteins such as X11, Dab, Fe65 and Numb apparently recognize NPXY or related peptide motifs, but are not dependent on ligand phosphorylation. In addition, the Numb PTB domain can bind an unrelated peptide that forms a helical turn.
Phosphoserine Motif definition: A protein motif containing a phosphorylated serine residue. These motifs can influence both protein-protein interactions and cellular signaling.
Trefoil Motif definition: Domain found in various secretory polypeptides that has highly conserved cysteine residues that are disulfide bonded in such a way as to generate a trefoil structure (bonded 1-5, 2-4, 3-6). There are also highly conserved A, G and W residues. (The Dictionary of Cell and Molecular Biology - Online)
Domain model definition: Holds a sub-set of the RIM that is the domain information model for the committee identified by the rest of the Subject Area name.
EE definition: Findings resulting from electroencephalogram (EEG) tests.
Electroencephalogram Domain definition: A subject domain utilized for the submission of information encompassing and representing data, vocabulary or records related to electroencephalogram.
EX definition: The Exposure domain model records the details of a subject's exposure to protocol-specified study treatment. Study treatment may be any intervention that is prospectively defined as a test material within a study, and is typically but not always supplied to the subject.
Exposure Domain definition: A subject domain utilized for the submission of information encompassing and representing data, vocabulary or records related to exposure.
AU definition: Additional data about deaths, specific to findings from autopsies.
Autopsy Domain definition: A subject domain utilized for the submission of information encompassing and representing data, vocabulary or records related to autopsy.
DM definition: The Demographics domain includes a set of essential standard variables that describe each subject in a clinical study. It is the parent domain for all other observations for human clinical subjects
Demographics Domain definition: A subject domain utilized for the submission of information encompassing and representing data, vocabulary or records related to demographics.
CO definition: The Comments dataset accommodates two sources of comments: 1) those collected alongside other data on topical case report form (CRF) pages such as Adverse Events and 2) those collected on a separate page specifically dedicated to comments.
Comment Domain definition: A subject domain utilized for the submission of information encompassing and representing data, vocabulary or records related to comments.
DS definition: A subject domain utilized for the submission of information encompassing and representing data, vocabulary or records related to disposition. (NCI)
Disposition Domain definition: A subject domain utilized for the submission of information encompassing and representing data, vocabulary or records related to disposition.
EG definition: Findings related to the collection of ECG data, including position of the subject, method of evaluation, all cycle measurements and all findings from the ECG including an overall interpretation if collected or derived.
Electrocardiogram Domain definition: A subject domain utilized for the submission of information encompassing and representing data, vocabulary or records related to electrocardiogram.
BR definition: Findings resulting from biopsies.
Biopsy Domain definition: A subject domain utilized for the submission of information encompassing and representing data, vocabulary or records related to biopsy.
Domain Name definition: An internet address in alphabetic form. Domain names must have at least 2 parts: the part on the left which names the organization, and the part on the right which identifies the highest subdomain, such as the country (e.g., fr for France, uk for United Kingdom) or the type of organization (e.g., com for commercial, edu for educational).
CDISC SDTM Submission Domain Abbreviation Terminology definition: Terminology codelist used with Submission Domain Abbreviation within the Clinical Data Interchange Standards Consortium Study Data Tabulation Model.
DOMAIN definition: A unique, 2-character domain code used in the regulatory submission process. The domain abbreviation is used consistently throughout the submission, i.e. in the dataset name, as the value of the domain variable within the dataset, and as a prefix for most variable names in the dataset. (CDISC Glossary)
Domain definition: An area of knowledge considered as a discreet unit for some purpose.
PG definition: Pharmacogenomics findings that initially focus on genotype and gene expression data.
Pharmacogenomics Domain definition: A subject domain utilized for the submission of information encompassing and representing data, vocabulary or records related to pharmacogenomics.
Domain definition: A collection of logically-related observations with a topic-specific commonality about the subjects in a trial, used in the regulatory submission process. The logic of the relationship may relate to the scientific subject matter of the data, or to its role in the trial. Typically, each domain is represented by a dataset, but it is possible to have information relevant to the same topicality spread among multiple datasets. (CDISC Glossary)
Superkingdom definition: A taxonomic category above that of Kingdom.
PDZ Domains definition: Protein interaction domains of about 70-90 amino acid residues, named after a common structure found in PSD-95, Discs Large, and Zona Occludens 1 proteins. PDZ domains are involved in the recruitment and interaction of proteins, and aid the formation of protein scaffolds and signaling networks. This is achieved by sequence-specific binding between a PDZ domain in one protein and a PDZ motif in another protein.
Extramembrane Domain definition: Any part of a transmembrane protein that is not embedded within the membrane.
domain definition: Domaine (1,2).
 
 
deGerman
Domäne definition: [1] ein Fachgebiet, ein Wissensgebiet [2] ein landwirtschaftliches oder forstwirtschaftliches Gut des Staates [3] ein großes Rittergut ab 1.000 Hektar [4] Biologie: die höchste taxonomische Einheit in der biologischen Systematik [5] Biochemie: eine eigenständige Teilstruktur eines Proteins [6] Physik: abgegrenzter Bereich gleicher Polarisation in der Festkörperphysik (Ferroelektrizität und Ferromagnetismus); makroskopischer Bereich in einem kritallinen Festkörper [7] Mathematik: reservierter Bereich bei einer Transformation, z.B. Fouriertransformation [8] Soziolinguistik: ein Fachgebiet, für welches eine Sprache verwendet wird [9]] Kognitionswissenschaft: eine alternative Bezeichnung für ein kognitives Modul [10] Informatik: ein abgrenzbares Problemfeld des täglichen Lebens in Softwaresystemen [11] Informatik: eine Struktur im Internet [12] Informatik: eine zentral verwaltete Computer-Netzwerkstruktur, häufig in lokalen Netzwerken anzutreffen, aufgebaut nach dem Client-Server-Prinzip
Gebiet definition: [1] räumlicher Bereich mit einer bestimmten Ausdehnung, Fläche [2] Fachbereich [3] Mathematik: offene, zusammenhängende Teilmenge eines topologischen Raumes
gemeinfrei definition: [1] keinem Urheberrecht unterliegend
Gemeinfreiheit definition: [1] Recht: Freiheit von jeglichem Urheberrecht
Domain definition: [1] ein Namensbereich, der zusammen mit dem Hostnamen dazu dient, Computer im Internet zu identifizieren, er ist unter anderem Bestandteil der URL einer Webseite Domain
 
frFrench
domaine definition: Propriété d’une assez vaste étendue et contenant des biens-fonds de diverse nature.
domaine definition: Ce qui appartient à l'État, au souverain.
domaine definition: Territoire colonial faisant partie des possessions coloniales d’un pays.
domaine definition: Secteur, branche, registre.
domaine definition: Compétence.
domaine definition: Ensemble d'adresses faisant l'objet d'une gestion commune.
super-règne definition: Niveau de classification scientifique des êtres vivants se situant au-dessus des règnes.