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Gene Expression definition: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
gene expression definition: the phenotypic manifestation of a gene or genes by the processes of gene action.
gene expression definition: The process by which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form. [GOC:dph, GOC:tb]
Gene Expression definition: Typically involves transcription of genetically encoded information into an intermediary message (messenger RNA) and subsequent translation into a functional protein.
Fibroblast Activation Protein, Alpha definition: Expressed in fibroblasts similar to DPP4 and DPPX, inducible Fibroblast Activation Protein-Alpha major isoform 1 (Long, 760-aa, 87.8-kD) and truncated isoform 2 (Short, 239-aa) are encoded by human FAP Gene (Peptidase S9B Family). Heterodimeric (with DPP4) or homodimeric, N-glycosylated FAPA is a type II integral membrane protein gelatinase: 13 extracellular cysteine residues and 3 conserved serine protease domains, a transmembrane segment, and a short cytoplasmic tail. Monomer is inactive. On lamellipodia, FAPA appears involved in epithelial-mesenchymal interactions during development, tissue repair/remodeling, epithelial carcinogenesis, and malignant invasion. A product of the same gene, monomeric N-glycosylated Seprase is composed of proteolytically inactive subunits whose activities depend on subunit association. (from LocusLink, Swiss-Prot, OMIM, and NCI)
Fibroblast Activation Protein, Alpha definition: An inducible cell surface glycoprotein. It is expressed on fibroblasts in many common epithelial cancers. It is a gelatinase belonging to the serine protease family. It is the target of BIBH 1 monoclonal antibody.
Expressed Emotion definition: Frequency and quality of negative emotions, e.g., anger or hostility, expressed by family members or significant others, that often lead to a high relapse rate, especially in schizophrenic patients. (APA, Thesaurus of Psychological Index Terms, 7th ed)
Expressed Sequence Tags definition: Partial cDNA (DNA, COMPLEMENTARY) sequences that are unique to the cDNAs from which they were derived.
Expressed Sequence Tag definition: Refers to Sequence Tagged Sites (EST) that are represented in mRNA. They are derived as 300-500 bp single-pass mRNA sequence reads from many of the genes expressed in a given tissue and/or at a given developmental stage. They represent a snapshot of gene expression in a given place or time.
Protein Expression definition: The biosynthesis of new (often sets of distinct, functionally related) protein products, usually involving new mRNA transcripts, typically in response to an activating stimulus.
CCL25 Gene definition: This gene is involved in the regulation of inflammatory processes.
Disabled Homolog 2 Protein definition: Encoded by human tumor suppressor DAB2 Gene, Disabled Homolog 2 Protein is expressed in ovarian, breast, and lung epithelial cells, spleen, thymus, prostate, testis, macrophages, fibroblasts, placenta, brainstem, heart, and small intestine. The 770-amino acid 82.5-kD predicted protein has 83% identity with mouse p96 protein, a putative mitogen-responsive phosphoprotein; strongest homology exists in the N-terminal PTB/PID domain. Potentially phosphorylated, DAB2 is a putative component of the CSF-1 cell proliferation signal transduction pathway. (from LocusLink, Swiss-Prot, OMIM, and NCI)
GRB10 Gene definition: This gene is involved in signal transduction. It plays a role in the regulation of both apoptosis and cell proliferation.
TCF21 Gene definition: This gene plays a role in embryonic trancriptional regulation.
Small Inducible Cytokine A25 definition: Expressed in thymic and intestinal dendritic cells by CCL25 Gene (Intercrine Beta Family), secreted immunoregulatory 150-aa 17-kD (precursor) Small Inducible Cytokine A25 is a CCR9 receptor agonist and chemotactic for thymocytes, activated macrophages, THP-1 cells, and dendritics cells in inflammatory processes. Two alternatively spliced gene variants encode antagonist isoforms. (NCI)
mRNA Expression definition: The synthesis or transcription of messenger RNA.
TIMP-3 definition: Encoded by widely expressed, mitogenically induced, and cell cycle regulated human TIMP3 Gene (TIMP Family), 27-kD glycosylated TIMP-3 is an angiogenesis inhibitor containing 12 conserved cysteines, localized in the ECM, and similar to TIMP-1 and TIMP-2. TIMP-3 complexes with and inactivates matrix metalloproteinases, involved in extracellular matrix degradation. TIMP family members may possess selective affinities for matrix metalloproteinases. Likely part of acute response tissue-specific remodeling, TIMP-3 acts on MMP-1, -2, -3, -7, -9, -13, -14 and -15. The N-terminus inhibits MMPs; the C-terminus mediates specific molecular functions. TIMP3 inhibits VEGF-mediated angiogenesis; it blocks VEGF binding to VEGFR2. Gene mutations cause Sorsby fundus dystrophy. (from LocusLink, Swiss-Prot, OMIM, and NCI)
Gene_Product_Expressed_In_Tissue definition: Expression is the cellular production of the protein encoded by a particular gene. The role is used to link the protein information where it is expressed. The domain and range kind for this role are Gene_Product_Kind and Anatomy_Kind, respectively.