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Definition
 
enEnglish
Chromatin Remodeling Complex and Coactivator Pathway definition: RXR and RAR are nuclear receptors that bind either all trans retinoic (tRA) or 9cis retinoic acid (9cisRA). In the absence of ligand corepressors with histone deacetylase activity are bound to the RAR/RXR hetrodimer and suppress transcription. Once they bind retinoic acid a conformational change in the receptors cause the dissociation of the corepressors and the binding of coactivators with histone acetylase activity. Following ligand binding by the hetrodimer the receptors and proteins in the basal transcription machinery (like TBP and TAF135) are degraded by the proteasome. (BioCarta)
facilitate definition: [1] einfacher machen, erleichtern
 
 
itItalian
agevolare definition: *
 
deGerman
erleichtern definition: [1] etwas leichter machen, für weniger Gewicht sorgen [2] psychischen Druck verringern oder beseitigen [3] wegnehmen (zum Beispiel: Geld, Vermögen)