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Definition
 
enEnglish
Age Factors definition: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
angiogenesis factor definition: group of agents that induce or stimulate the physiologic angiogenesis process.
Angiogenesis Factor definition: Substance causing proliferation of new blood vessels. It is found in tissues with high metabolic requirements, such as the retina, and in certain cancers. The factor is also released by hypoxic macrophages at the edges or outer surfaces of wounds and initiates revascularization in wound healing.
Antibodies, Antinuclear definition: Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.
antinuclear autoantibody definition: autoimmune, pathological antibodies against histones, DNA, nuclear RNA, or other components of the cell nucleus.
Antinuclear Antibody definition: An autoimmune antibody that is directed against structures within the nucleus of the cell.
Biological Factors definition: Endogenously-synthesized compounds that may influence biological phenomena or represent quantifiable biomarkers. Biological factors are a variety of extracellular substances that are not otherwise classified under ENZYMES; HORMONES or HORMONE ANTAGONISTS
Blood Coagulation Factors definition: Endogenous substances, usually proteins, that are involved in the blood coagulation process.
clotting factor definition: class of endogenous substances, usually proteins, that are involved in the blood coagulation process.
Coagulation Factor definition: Factors in the blood that are essential for blood coagulation. The absence or mutation of these factors can lead to hemophilia and blood clotting disorders.
Chemotactic Factors definition: Chemical substances that attract or repel cells. The concept denotes especially those factors released as a result of tissue injury, microbial invasion, or immunologic activity, that attract LEUKOCYTES; MACROPHAGES; or other cells to the site of infection or insult.
chemoattractant definition: any chemotactic factor that induces positive chemotaxis.
Bacteriocin Plasmids definition: Plasmids encoding bacterial exotoxins (BACTERIOCINS).
Cord Factors definition: Toxic glycolipids composed of trehalose dimycolate derivatives. They are produced by MYCOBACTERIUM TUBERCULOSIS and other species of MYCOBACTERIUM. They induce cellular dysfunction in animals.
Factor IX definition: Storage-stable blood coagulation factor acting in the intrinsic pathway. Its activated form, IXa, forms a complex with factor VIII and calcium on platelet factor 3 to activate factor X to Xa. Deficiency of factor IX results in HEMOPHILIA B (Christmas Disease).
Coagulation Factor IX definition: Factor IX is a vitamin k-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of ca(2+) ions, phospholipids, and factor VIIIa.
Factor VIII definition: Blood-coagulation factor VIII. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.
coagulation factor VIII definition: antihemophilic factor that is part of the factor VIII/von Willebrand factor complex; produced in the liver and acts in the intrinsic pathway of blood coagulation; serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.
Coagulation Factor VIII definition: Human coagulation factor-VIII (2351 aa, 267 kDa precursor) is encoded by human factor eight (F8) gene. The protein is an extracellular anti-hemophilic factor that is part of the von Willebrand factor complex. The protein plays a role in the blood coagulation pathway.
Platelet Factor 4 definition: A CXC chemokine that is found in the alpha granules of PLATELETS. The protein has a molecular size of 7800 kDa and can occur as a monomer, a dimer or a tetramer depending upon its concentration in solution. Platelet factor 4 has a high affinity for HEPARIN and is often found complexed with GLYCOPROTEINS such as PROTEIN C.
platelet factor 4 definition: high molecular weight proteoglycan-platelet factor complex which is released from blood platelets by thrombin; acts as a mediator in the heparin-neutralizing capacity of the blood and plays a role in platelet aggregation.
Platelet Factor 4 definition: Platelet factor-4 is a 70-amino acid CXC chemokine. It is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. (from OMIM)
Recombinant Platelet Factor 4 definition: A recombinant form of the endogenous chemokine platelet factor 4 with potential antiangiogenesis and antineoplastic activities. As a heparin-binding tetramer, recombinant platelet factor 4 inhibits growth factor-stimulated endothelial cell proliferation, migration, and angiogenesis; it has been shown that this agent inhibits fibroblast growth factor 2 (FGF2) angiogenic activity downstream from the FGF2 receptor. Its activity is antagonized by heparin. Recombinant platelet factor 4 may also directly inhibit the proliferation of some tumor cell types.
Proto-Oncogene Proteins c-mos definition: Cellular proteins encoded by the c-mos genes (GENES, MOS). They function in the cell cycle to maintain MATURATION PROMOTING FACTOR in the active state and have protein-serine/threonine kinase activity. Oncogenic transformation can take place when c-mos proteins are expressed at the wrong time.
MOS pp39 Serine/Threonine Kinase definition: Cellular proteins encoded by the c-mos genes (GENES, MOS). They function in the cell cycle to maintain MATURATION PROMOTING FACTOR in the active state and have protein-serine/threonine kinase activity. Oncogenic transformation can take place when c-mos proteins are expressed at the wrong time.
leucovorin calcium definition: An active metabolite of folic acid (also called folinic acid and citrovorum factor), which does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist-type chemotherapeutic drugs. Leucovorin calcium counteracts the toxic effects of these medications, 'rescuing' the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug's metabolite to its target enzyme, thus prolonging drug activity. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42584&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42584&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C607" NCI Thesaurus)
Leucovorin Calcium definition: An active metabolite of folic acid (also called folinic acid and citrovorum factor), which does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist-type chemotherapeutic drugs. Leucovorin calcium counteracts the toxic effects of these medications, 'rescuing' the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug's metabolite to its target enzyme, thus prolonging drug activity. (NCI04)
Semaphorin-3A definition: The prototypical and most well-studied member of the semaphorin family. Semaphorin-3A is an axon-repulsive guidance cue for migrating neurons in the developing nervous system. It has so far been found only in vertebrates, and binds to NEUROPILIN-1/plexin complex receptors on growth cones. Like other class 3 semaphorins, it is a secreted protein.
Colicin Plasmids definition: Plasmids encoding COLICINS.
LIF Gene definition: This gene is involved in macrophage differentiation.
Leukemia Inhibitory Factor definition: Leukemia Inhibitory Factor (LIF) affects many systems, including hematopoietic, embryonic, bone, hepatic, neuronal, and fat tissues. LIF induces MHC class I HLA-G expression by cytotrophoblasts, which is essential in implantation and may facilitate immune tolerance of the conceptus at the maternal-fetal interface. LIF, secreted by ureteric bud cells, converts kidney mesenchyme to epithelia, which then forms nephrons. LIF and BMP2 cytokines signal through different receptors and transcription factors (STATs and SMADs) and act in synergy on neural progenitors to induce astrocytes. Transcriptional co-activator p300 interacts with STAT3 in a cytokine-independent manner and with SMAD1 in a cytokine-dependent manner. Formation of a STAT3/SMAD1 complex, bridged by p300, mediates cooperative signaling of LIF and BMP2 and induction of astrocytes from neuronal progenitors. (from OMIM and NCI)
Leukemia Inhibitory Factor definition: Leukemia inhibitory factor is a cytokine that induces macrophage differentiation. Neurotransmitters and neuropeptides, well known for their role in the communication between neurons, are also capable of activating monocytes and macrophages and inducing chemotaxis in immune cells. LIF signals through different receptors and transcription factors. LIF in conjunction with BMP2 acts in synergy on primary fetal neural progenitor cells to induce astrocytes. (LocusLink)
Diagnostic Factor definition: A biological, physiological, behavioral, or molecular indicator of the presence or predisposition towards development of a specific disease.
Factor definition: Anything that contributes causally to a result.
Calibration Factor definition: Factor by which a measured or calculated value is multiplied to obtain the estimated real-world value.
factor definition: Facteur, des éléments qui concourent à un résultat.
factor definition: Facteur, nombre qui se multiplie avec un autre nombre.
factor definition: Factoriser.
 
 
deGerman
Faktor definition: [1] math.: Teil eines Produktes (Faktor x Faktor = Produkt) [2] mitwirkender Bestandteil
Klirrfaktor definition: [1] ein Maß für die Verzerrung bei akustischen Übertragungen
 
arArabic
عامل definition: [1] Faktor [2] Motiv, Motivation [3] Koeffizient
 
frFrench
affactureur definition: Entreprise pratiquant l’affacturage.
rhésus definition: Macaque '''rhésus''' (''Macaca mulatta'') ou singe '''rhésus''' ou bandar, l’une des espèces de singes les plus connues de l’Ancien monde, commune en Afghanistan, Inde septentrionale et Chine méridionale, et souvent utilisée comme animal de laboratoire.
rhésus definition: Antigène présent ('''rhésus''' positif, symbole Rh+) ou absent ('''rhésus''' négatif, symbole Rh-) dans les globules rouges du sang, ce qui détermine le groupe sanguin.
 
ptPortuguese
agente definition: Agent.
autor definition: L’auteur.