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Neoplastic Syndromes, Hereditary definition: The condition of a pattern of malignancies within a family, but not every individual's necessarily having the same neoplasm. Characteristically the tumor tends to occur at an earlier than average age, individuals may have more than one primary tumor, the tumors may be multicentric, usually more than 25 percent of the individuals in direct lineal descent from the proband are affected, and the cancer predisposition in these families behaves as an autosomal dominant trait with about 60 percent penetrance.
Hereditary Neoplastic Syndrome definition: The inherited predisposition toward getting a cancer
Li-Fraumeni Syndrome definition: Rare autosomal dominant syndrome characterized by mesenchymal and epithelial neoplasms at multiple sites. MUTATION of the p53 tumor suppressor gene, a component of the DNA DAMAGE response pathway, apparently predisposes family members who inherit it to develop certain cancers. The spectrum of cancers in the syndrome was shown to include, in addition to BREAST CANCER and soft tissue sarcomas (SARCOMA); BRAIN TUMORS; OSTEOSARCOMA; LEUKEMIA; and ADRENOCORTICAL CARCINOMA.
Li-Fraumeni syndrome definition: A rare, inherited predisposition to multiple cancers, caused by an alteration in the p53 tumor suppressor gene.
Li Fraumeni syndrome definition: rare autosomal dominant syndrome characterized by mesenchymal and epithelial neoplasms at multiple sites; a point mutation of the p53 tumor suppressor gene apparently predisposes family members who inherit it to develop certain cancers including early breast carcinoma; associated with soft tissue sarcomas and other tumors.
Li-Fraumeni Syndrome definition: An autosomal dominant hereditary neoplastic syndrome caused by an alteration in the p53 tumor suppressor gene. It is characterized by the development of malignant neoplasms at various anatomic sites. The malignant neoplasms associated with Li-Fraumeni syndrome include adrenal cortex carcinoma, astrocytic tumors, colorectal carcinoma, gastric carcinoma, malignant breast neoplasms, medulloblastoma, osteosarcoma, and soft tissue sarcomas.
Known definition: Recognized, familiar, or within the scope of knowledge.
Hereditary Wilms Tumor definition: Familial embryonal neoplasm derived from nephrogenic blastemal cells. Several lines of differentiation, including blastemal, stromal and epithelial, are usually expressed. Comprises approximately 1% of Wilms tumors. (AFIP fascicle version 2.0 mo011000)
familial cancer definition: Cancer that occurs in families more often than would be expected by chance. These cancers often occur at an early age, and may indicate the presence of a gene mutation that increases the risk of cancer. They may also be a sign of shared environmental or lifestyle factors.
Hereditary Malignant Neoplasm definition: Cancer aggregating among blood relatives. Does not necessarily imply a genetic inheritance.
Hereditary Thyroid Gland Medullary Carcinoma definition: A medullary thyroid gland carcinoma inherited through an autosomal dominant mode. It is associated with multiple endocrine neoplasia type II (2a) or III (2b). (NCI05)
Familiar Juvenile Nephronophthisis definition: Progressive tubulointerstitial nephritis inherited in an autosomal recessive manner. It is caused by mutations in the NPHP1 gene. Patients present with anemia, polyuria, and polydipsia during childhood. The progressive bilateral kidney damage results in renal failure.
Umgangssprache definition: [1] Linguistik: Form der Sprache (Sprachvarietät), die zwischen Standardsprache und Dialekt angesiedelt ist [2] Linguistik: Bezeichnung für Sprachstile, die im eher privaten, informellen Sprachgebrauch verwendet werden und sich dabei von der Standardsprache unterscheiden
häuslich definition: [1] Auf das eigene Heim bezogen; mit dem eigenen Heim verbunden
Schrebergarten definition: [1] ein kleiner Garten innerhalb einer Gartenanlage
KZ definition: [1] Abkürzung, Kurzwort, Akronym für Konzentrationslager [2] Abkürzung für Kasachstan (auf Englisch Kazakhstan) [3] Abkürzung für Kennzeichen [4] Abkürzung für Kinderzulage [5] Abkürzung für Koordinationszahl
Koseform definition: [1] Linguistik: Form/Wortbildung von Kosenamen
intime definition: Personne très proche.
intime definition: Du verbe '''intimer'''.
parent definition: Le père et la mère, collectivement (c’est la signification étymologique et propre).
parent definition: Le père ou la mère d’une personne, d’un enfant.
parent definition: Ceux de qui on descend.
parent definition: Membre de la même famille, de la parentèle. Dans cette acception, il s'utilise aussi au féminin.
familier definition: Proche considéré comme de la famille.
familier definition: Créature, parfois fantastique, supposée entretenir un rapport mystique avec un magicien ou sorcier.