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Helix (Snails) definition: A genus of chiefly Eurasian and African land snails including the principal edible snails as well as several pests of cultivated plants.
Upstream Stimulatory Factor definition: The upstream stimulatory factor is a ubiquitously expressed cellular transcription factor that binds to a symmetrical DNA sequence that is found in a variety of viral and cellular promoters. Purified USF consists of 2 related polypeptides of 43 and 44 kD encoded by USF1 and USF2, respectively. USF is known to be involved in the regulation of many gene with direct and indirect roles in cancer. (from OMIM and NCI)
Upstream Stimulatory Factor definition: The ubiquitous bZIP transcription factor Upstream Stimulatory Factor binds to many viral and cellular promoters. USF consists of two related polypeptides USF1 and USF2. USF function may support the host immune response by promoting MHC class I and class II antigen expression. (from OMIM 191523, 600390 and NCI)
Upstream Stimulatory Factors definition: Ubiquitously expressed basic HELIX-LOOP-HELIX MOTIF transcription factors. They bind CANNTG sequences in the promoters of a variety of GENES involved in carbohydrate and lipid metabolism.
Helix-Loop-Helix Motifs definition: Recurring supersecondary structures characterized by 20 amino acids folding into two alpha helices connected by a non-helical "loop" segment. They are found in many sequence-specific DNA-BINDING PROTEINS and in CALCIUM-BINDING PROTEINS.
Helix-Loop-Helix Domain definition: In transcription regulators of cell cycle control, cell determination, and cell differentiation, the conserved HLH (Helix-Loop-Helix) Domain of 40-50 amino acids forms amphipathic helixes between a variable loop. HLHs typically mediate homo- or heterodimerization through interactions with self or other motifs to activate or inactivate trans-activating function. The N-helix often contains DNA-interacting basic residues; the C-helix typically contains characteristically spaced hydrophobic residues. An adjacent basic region of 15 amino acids in most HLH proteins binds to DNA. Basic (b)HLH proteins bind variants of the 'CANNTG' E-box. Proteins lacking the basic domain act as inhibitors, failing to bind DNA. bHLH proteins exhibit specific dimerization partner combinations. In calcium-binding proteins, certain invariant hydrophilic loop residues in the HLH motif bind calcium. (NCI)
Helix-Turn-Helix Motifs definition: The first DNA-binding protein motif to be recognized. Helix-turn-helix motifs were originally identified in bacterial proteins but have since been found in hundreds of DNA-BINDING PROTEINS from both eukaryotes and prokaryotes. They are constructed from two alpha helices connected by a short extended chain of amino acids, which constitute the "turn." The two helices are held at a fixed angle, primarily through interactions between the two helices. (From Alberts et al., Molecular Biology of the Cell, 3d ed, p408-9)
Helix-Turn-Helix Motif definition: The first DNA-binding protein motif to be recognized. Originally identified in bacterial proteins and found in many DNA-binding proteins from both eukaryotes and prokaryotes. They are constructed from two alpha helices connected by a short extended chain of amino acids, which constitute the "turn." The two helices are held at a fixed angle, primarily through interactions between the two helices.
BHLH Protein definition: Term used to denote the class of sequence-specific DNA-binding proteins that contain the bHLH domain.
BHLH Protein definition: bHLH class proteins are sequence-specific DNA-binding proteins that contain a conserved 50-amino acid HLH domain consisting of two alpha-helices separated by a variable loop sequence, adjacent to a sequence that is highly enriched in basic amino acids. The HLH region mediates protein dimerization, while the basic region mediates sequence-specific DNA binding. Many bHLH proteins recognize a DNA sequence known as the E box. Class A bHLH proteins are ubiquitously expressed, while class B bHLH proteins are expressed in specific cell types. In general, class B proteins preferentially bind to DNA as heterodimers with class A proteins and function as transcriptional activators.
Basic Helix-Loop-Helix Transcription Factors definition: A family of DNA-binding transcription factors that contain a basic HELIX-LOOP-HELIX MOTIF.
Alpha Helix definition: A right-handed spiral conformation; the a-helix has a pitch of 5.4 A and has 3.6 amino acid residues per turn; every main chain C=O and N-H group is hydrogen-bonded to a peptide bond 4 residues away; the peptide planes are roughly parallel with the helix axis and the dipoles within the helix are aligned, i.e. all C=O groups point in the same direction and all N-H groups point the other way; side chains point outward from helix axis and are generally oriented towards its amino-terminal end. (from expasy.org)
Conserved Helix-Loop-Helix Ubiquitous Kinase definition: Widely expressed by human CHUK Gene (Ser/Thr IKBK Family), 745-aa 85-kDa Conserved Helix-Loop-Helix Ubiquitous Kinase is an autophosphorylated cytoplasmic protein found in active heterodimer with IKK-beta bound to MAP3K14/NIK, MEKK1, IKAP, IKB-alpha-p65-p50 complex, and in complex with NCOA2, NCOA3, IKKB, IKBKG, and CREBBP. CHUK may interact with TRAF2, IKK-gamma/NEMO, and TRPC4AP. Inactivated by PP2A and activated by MAP3K14/NIK, AKT, and MEKK1, CHUK (or IKBKB) serine phosphorylates NFKB inhibitors (I-Kappa-Bs, NFKBIA or NFKBIB) leading to dissociation from cytoplasmically-trapped NFKB and ubiquitinated inhibitor degradation. Activated NFKB translocates to the nucleus, binds at kappa-B DNA binding motifs, and regulates transcription of target genes. CHUK also phosphorylates NCOA3. (NCI)
triple helix definition: three stranded molecular conformation.
RGS2 Gene definition: This gene is involved in signal transduction, cell cycle control and regulation of transcription.
Transcription Factor 3 definition: Encoded by human TCF3 Gene, E12 and E47 alternative isoforms of 654-aa 68-kDa nuclear bHLH Transcription Factor 3 are homologous to MYOD, MYC, 'daughterless', 'achaete-scute' and 'twist' families. As a heterodimer with tissue-specific bHLH proteins (e.g., ASH1 and TWIST2), TCF3 determines diverse cell fates during embryogenesis. TCF3 heterodimers bind DNA on CANNTG E-box motifs, such as kappa Ig gene enhancer E2 sites. TCF3 is likely phosphorylated following NGF stimulation. Crucial in dimerization and DNA binding, the bHLH motif forms 2 amphipathic helices that contain highly conserved hydrophobic residues. TCF3 is involved in B-ALL through a t(1;19)(q23;p13.3) translocation and fusion with PBX1. (NCI)
CHUK Gene definition: This gene plays a role in signal transduction and regulation of transcription.
Musculin definition: The predicted 218-amino acid protein contains a bHLH motif, a putative nuclear localization signal, a glycine-rich region, and a stretch of acidic residues. MSC is capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro, and forms heterodimers with E2A proteins in vivo. MSC contains a transcriptional repression domain and is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. MSC is a downstream target of the B-cell receptor signal transduction pathway. Mice engineered to lack the protein lack muscle structures derived from the first brachial arch. (from LocusLink and OMIM)
Winged Helix definition: The winged helix is a common, 100 amino acid DNA-binding domain which is a variant of the helix-turn-helix motif found in the "forkhead" transcription factor gene family.
Protein Helix definition: A protein secondary structure motif. Amino acids are arranged in a right-handed rod like structure stabilized by hydrogen bonds between the C=O and the N-H groups of the main chain. Types include:alpha-helix, 3.10 helix and pi-helix.
Helix definition: A structure consisting of something wound in a continuous series of loops.
helix definition: Hélice.
screw-thread definition: Hélice.
Wendel definition: [1] schraubenförmige Struktur und deren technische Anwendung
Helix definition: [1] Windung, Spirale
hélix definition: [1] Ohrrand
hélix definition: Le grand bord replié de l’oreille externe.
hélice definition: Ligne tracée en forme de vis autour d’un cylindre.
hélice definition: Petites volutes qui entrent dans la composition du chapiteau corinthien.
hélice definition: Certains coquillages univalves, contournés en spirale.
hélice definition: Appareil de propulsion qui rappelle la forme de la vis, composé de plusieurs branches et mis en action par un moteur.
spiraal definition: Hélice.
spiraal definition: Spirale.
helix definition: Hélice.
propeller definition: Hélice.
spiraallijn definition: Hélice.
schroeflijn definition: Hélice.
schroefdraad definition: Hélice.
schroef definition: Vis.
schroef definition: Hélice.
cargol definition: Vis.
cargol definition: Escargot, limaçon.
cargol definition: Hélice.
hèlice definition: Hélice.
hèlix definition: Hélice.
helix definition: Lierre.
helix definition: Hélice (ornement de chapiteau).