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carboxyhemoglobin definition: hemoglobin in which the sites usually bound to oxygen are bound to carbon monoxide.
Fetal Hemoglobin definition: The major component of hemoglobin in the fetus. This HEMOGLOBIN has two alpha and two gamma polypeptide subunits in comparison to normal adult hemoglobin, which has two alpha and two beta polypeptide subunits. Fetal hemoglobin concentrations can be elevated (usually above 0.5%) in children and adults affected by LEUKEMIA and several types of ANEMIA.
hemoglobin F definition: fetal hemoglobin; major component of hemoglobin in the fetus; it has two alpha and two gamma polypeptide subunits in comparison to normal adult hemoglobin, which has two alpha and two beta polypeptide subunits.
Hemoglobin A definition: Normal adult human hemoglobin. The globin moiety consists of two alpha and two beta chains.
hemoglobin A definition: normal adult hemoglobin, composed of 2 alpha and 2 beta chains.
Hemoglobin A, Glycosylated definition: Minor hemoglobin components of human erythrocytes designated A1a, A1b, and A1c. Hemoglobin A1c is most important since its sugar moiety is glucose covalently bound to the terminal amino acid of the beta chain. Since normal glycohemoglobin concentrations exclude marked blood glucose fluctuations over the preceding three to four weeks, the concentration of glycosylated hemoglobin A is a more reliable index of the blood sugar average over a long period of time.
Hemoglobin A2 definition: An adult hemoglobin component normally present in hemolysates from human erythrocytes in concentrations of about 3%. The hemoglobin is composed of two alpha chains and two delta chains. The percentage of HbA2 varies in some hematologic disorders, but is about double in beta-thalassemia.
Hemoglobin C definition: A commonly occurring abnormal hemoglobin in which lysine replaces a glutamic acid residue at the sixth position of the beta chains. It results in reduced plasticity of erythrocytes.
hemoglobin C definition: abnormal hemoglobin caused by a point mutation in the beta chains, associated with splenomegaly, jaundice, or mild hemolytic anemia.
Hemoglobin E definition: An abnormal hemoglobin that results from the substitution of lysine for glutamic acid at position 26 of the beta chain. It is most frequently observed in southeast Asian populations.
Hemoglobin H definition: An abnormal hemoglobin composed of four beta chains. It is caused by the reduced synthesis of the alpha chain. This abnormality results in ALPHA-THALASSEMIA.
hemoglobin H definition: abnormal hemoglobin composed of 4 beta chains, found in alpha thalassemia, and associated with severe hemolytic anemia.
Hemoglobins definition: The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.
hemoglobin definition: oxygen carrying pigment of the erythrocytes; a complex protein composed of four heme groups and four globin polypeptide chains.
hemoglobin definition: The substance inside red blood cells that carries oxygen molecules.
Hemoglobin definition: The red respiratory protein of erythrocytes, consisting of approximately 3.8% heme and 96.2% globin (64.5 KD), which as oxyhemoglobin (HbO2) transports oxygen from the lungs to the tissues where the oxygen is readily released and HbO2 becomes Hb.
Hemoglobin Decreased definition: A laboratory test result which indicates decreased levels of hemoglobin in a biological specimen.
HEMOGLOBINOMETER definition: A whole blood hemoglobin assay is a device consisting or reagents, calibrators, controls, or photometric or spectrophotometric instrumentation used to measure the hemoglobin content of whole blood for the detection of anemia. This generic device category does not include automated hemoglobin systems.
Analyzers, Laboratory, Hematology, Hemoglobin definition: Laboratory hematology analyzers designed to determine the quantity of hemoglobin (the oxygen carrying protein of the erythrocytes) in blood, using a standard spectrophotometric method that measures the 540 nm absorption maximum of cyanmethemoglobin. The procedure is performed after a suitable reagent has been added to the specimen of whole blood to hemolyze red cells and convert hemoglobin to cyanmethemoglobin.
Glycosylated Hemoglobin Measurement definition: A quantitative measurement of the amount of glycosylated hemoglobin present in a sample of blood.
Hemoglobin A1C definition: A measurement of the glycosylated hemoglobin in a biological specimen.
CONTROL, HEMOGLOBIN definition: A hematology quality control mixture is a device used to ascertain the accuracy and precision of manual, semiautomated, and automated determinations of cell parameters such as white cell count (WBC), red cell count (RBC), platelet count (PLT), hemoglobin, hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC).
Hemoglobin Measurement definition: A quantitative measurement of the amount of hemoglobin present in a sample.
Hemoglobin definition: A measurement of the hemoglobin in a biological specimen.
hemoglobin biosynthetic process definition: The chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin. [GOC:jl, http://cancerweb.ncl.ac.uk/]