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Interferon-alpha definition: One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells. In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES, and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways.
interferon alpha definition: major interferon produced by virus-exposed leukocytes; has antiviral activity and activates NK cells; used in the treatment of hairy cell leukemia and other neoplasms.
interferon alfa definition: A class of naturally-isolated or recombinant therapeutic peptides used as antiviral and anti-tumor agents. Alpha interferons are cytokines produced by nucleated cells (predominantly natural killer (NK) leukocytes) upon exposure to live or inactivated virus, double-stranded RNA or bacterial products. These agents bind to specific cell-surface receptors, resulting in the transcription and translation of genes containing an interferon-specific response element. The proteins so produced mediate many complex effects, including antiviral effects (viral protein synthesis); antiproliferative effects (cellular growth inhibition and alteration of cellular differentiation); anticancer effects (interference with oncogene expression); and immune-modulating effects (natural killer cell activation, alteration of cell surface antigen expression, and augmentation of lymphocyte and macrophage cytotoxicity). Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40467&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40467&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C225" NCI Thesaurus)
Interferon-beta definition: One of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA. It is a cytokine with antiviral, antiproliferative, and immunomodulating activity.
interferon beta definition: major interferon produced by double stranded RNA induced fibroblast cultures; the primary producer cells are fibroblasts, epithelial cells and macrophages, and the major activity is antiviral.
Interferon Beta definition: A class of interferon elaborated by fibroblasts.
Interferon Alfa-2a definition: A recombinant alfa interferon consisting of 165 amino acids with lysine at position 23 and histidine at position 34. It is used extensively as an antiviral and antineoplastic agent.
recombinant interferon alpha-2a definition: A non-glycosylated recombinant human alpha interferon, subtype 2a, produced in the bacterium E. coli. Interferon alpha-2a binds to its specific cell-surface receptor, resulting in the transcription and translation of genes whose protein products have antiviral, antiproliferative, anticancer, and immune modulating effects. (NCI04) Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=467189&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=467189&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1952" NCI Thesaurus)
Recombinant Interferon Alpha-2a definition: A non-glycosylated recombinant human alpha interferon, subtype 2a, produced in the bacterium E. coli. Interferon alpha-2a binds to its specific cell-surface receptor, resulting in the transcription and translation of genes whose protein products have antiviral, antiproliferative, anticancer, and immune modulating effects. (NCI04)
Interferon Alfa-2b definition: A recombinant alfa interferon consisting of 165 amino acid residues with arginine in position 23 and histidine in position 34. It is used extensively as an antiviral and antineoplastic agent.
recombinant interferon alfa-2b definition: A non-glycosylated recombinant interferon with antiviral and antineoplastic activities. Alfa interferons bind to specific cell-surface receptors, resulting in the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer, and immune-modulating effects. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=462279&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=462279&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1953" NCI Thesaurus)
recombinant interferon alfa-2b definition: A non-glycosylated recombinant interferon alpha, subtype 2b, used as an antiviral and antineoplastic agent. Alpha interferons bind to specific cell-surface receptors, resulting in the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer, and immune-modulating effects. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=448847&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=448847&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1953" NCI Thesaurus)
Recombinant Interferon Alfa-2b definition: A non-glycosylated recombinant interferon with antiviral and antineoplastic activities. Alfa interferons bind to specific cell-surface receptors, resulting in the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer, and immune-modulating effects.
Interferon-gamma, Recombinant definition: A type II interferon produced by recombinant DNA technology. It is similar to the interferon secreted by lymphocytes and has antiviral and antineoplastic activity.
Recombinant Interferon Gamma definition: A recombinant therapeutic agent which is chemically identical to or similar to the endogenous lymphokine interferon gamma (IFN-gamma) with antineoplastic, immunoregulatory, and antiviral activities. Therapeutic IFN-gamma binds to and activates the cell-surface IFN-gamma receptor, stimulating antibody-dependent cytotoxicity and enhances natural killer cell attachment to tumor cells. This agent also activates caspases, thereby inducing apoptosis in malignant cells. (NCI04)
Interferon Inducers definition: Agents that promote the production and release of interferons. They include mitogens, lipopolysaccharides, and the synthetic polymers Poly A-U and Poly I-C. Viruses, bacteria, and protozoa have been also known to induce interferons.
interferon inducer definition: agents that promote the production and release of interferons; they include mitogens, lipopolysaccharides, and the synthetic polymers Poly A-U and Poly I-C; viruses, bacteria, and protozoa have been also known to induce interferons.
interferon gamma definition: activates NK cells, cytotoxic T cells, endothelial cells, and macrophages; stimulates LAK activity; costimulates B cell proliferation; inhibits T cell proliferation; implicated in aberrant expression of MHC II antigens leading to autoimmune disease.
Interferon-gamma definition: The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
interferon gamma definition: A recombinant therapeutic agent which is chemically identical to or similar to the endogenous lymphokine interferon gamma (IFN-gamma) with antineoplastic, immunoregulatory, and antiviral activities. Therapeutic IFN-gamma binds to and activates the cell-surface IFN-gamma receptor, stimulating antibody-dependent cytotoxicity and enhances natural killer cell attachment to tumor cells. This agent also activates caspases, thereby inducing apoptosis in malignant cells. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40469&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40469&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C583" NCI Thesaurus)
Interferon Gamma definition: The gamma or immune IFNs are produced by T lymphocytes in response to mitogens or to antigens to which they are sensitized. They are acid-labile and serologically distinct from alpha- and beta-IFNs. (from OMIM 147570)
Interferon Gamma definition: Interferon gamma (IFNg) is produced by activated T cells and is an important immunoregulatory molecule, particularly in allergic diseases.
Interferons definition: Proteins secreted by vertebrate cells in response to a wide variety of inducers. They confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions.
interferon definition: a group of proteins elaborated by infected host cells that protect noninfected cells from viral infection.
Interleukin-6 definition: A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS.
interleukin 6 definition: cytokine produced by antigen or mitogen activated T lymphocytes, fibroblasts and macrophages that serves as a differentiation factor for lymphocytes and stimulates immunoglobulin production by B lymphocytes; it also innitiates the cell cycle in primitive hematopoietic cells in vitro.
interleukin-6 definition: (in-ter-LOO-kin) IL-6. A type of biological response modifier (a substance that can improve the body's natural response to infection and disease). These substances are normally produced by the body, but they can also be made in the laboratory for use in treating cancer and other diseases.
Interleukin-6 definition: Interleukin-6 (IL-6), a glycoprotein produced by activated T-cells and a variety of other cells, induces the production of IgM by B-cells and can be used to replace feeder cells for the growth and maintenance of B-cell hybridomas in vitro.
Interleukin-6 definition: Produced by T-cells, monocytes, fibroblasts, and many other cells, Interleukin 6 stimulates the growth of hybridomas and plasmacytomas, as well as the growth and differentiation of B-cells. Il6 increases synthesis and secretion of immunoglobulins by B-lymphocytes. The biologic significance of IL6 lies in the fact that it is induced under conditions in which IFN-beta 1 is not induced, as in metabolically stressed cells. Its induction by IL1 and TNF suggests that it may play a role as an autocrine mediator of these cytokines in inflammation and acute phase responses, as well as regulate cell proliferation. In addition to its antiviral activity, IL6 elicits an acute phase response in liver cells and is identical to hepatocyte stimulatory factor. (from OMIM 147620 and NCI)
Receptors, Interferon definition: Specific molecular sites or structures on or in cells with which interferons react or to which they bind in order to modify the function of the cells. Interferons exert their pleiotropic effects through two different receptors. alpha- and beta-interferon crossreact with common receptors, while gamma-interferon initiates its biological effects through its own specific receptor system.
Interferon Omega 1 definition: Encoded by human IFNW1 Gene (IFN Alpha, Beta, Delta Family), secreted 195-amino acid 22 kD (precursor) Interferon Omega 1, a type I interferon protein containing the interferon alpha/beta domain, appears to regulate antiviral defense, cell growth, and immune activation. (from LocusLink, Swiss-Prot, OMIM, and NCI)
Interferon Alfa-2c definition: A recombinant alfa interferon consisting of 165 amino acids with arginine at positions 23 and 34. It is used extensively as an antiviral and antineoplastic agent.
methionyl-interferon-consensus definition: An analogue of consensus interferon which contains an additional methionyl amino acid residue. Consensus interferon (also known as interferon alfacon-1, rCon-IFN, and CIFN) is a genetically engineered synthetic interferon created from the most common amino acid sequences from the naturally occurring alpha interferons. Alpha interferons bind to specific cell-surface receptors, resulting in the transcription and translation of genes whose protein products have antiviral, antiproliferative, anticancer, and immune-modulating effects. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41245&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41245&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2369" NCI Thesaurus)
interferon alfacon-1 definition: An analogue of consensus interferon which contains an additional methionyl amino acid residue. Consensus interferon (also known as interferon alfacon-1, rCon-IFN, and CIFN) is a genetically engineered synthetic interferon created from the most common amino acid sequences from the naturally occurring alpha interferons. Alpha interferons bind to specific cell-surface receptors, resulting in the transcription and translation of genes whose protein products have antiviral, antiproliferative, anticancer, and immune-modulating effects. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42870&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42870&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1766" NCI Thesaurus)
Interferon Alfacon-1 definition: An analogue of consensus interferon which contains an additional methionyl amino acid residue. Consensus interferon (also known as interferon alfacon-1, rCon-IFN, and CIFN) is a genetically engineered synthetic interferon created from the most common amino acid sequences from the naturally occurring alpha interferons. Alpha interferons bind to specific cell-surface receptors, resulting in the transcription and translation of genes whose protein products have antiviral, antiproliferative, anticancer, and immune-modulating effects.
Interferon Alfacon-1 definition: An analogue of consensus interferon which contains an additional methionyl amino acid residue. Consensus interferon (also known as interferon alfacon-1, rCon-IFN, and CIFN) is a genetically engineered synthetic interferon created from the most common amino acid sequences from the naturally occurring alpha interferons. Alpha interferons bind to specific cell-surface receptors, resulting in the transcription and translation of genes whose protein products have antiviral, antiproliferative, anticancer, and immune-modulating effects. (NCI04)
Interferon Beta-1B definition: A recombinant form of the natural Interferon beta that varies in the amino acid sequence and lacks the carbohydrate side chain. Clinical Use: Multiple Sclerosis.
Interferon Alpha 2 definition: Encoded by human INFA2 Gene (IFN Alpha Family) and expressed by macrophages, secreted 188-amino acid 21.6 kD (precursor) Interferon Alpha 2 contains the interferon alpha/beta domain, exhibits interferon-alpha/beta receptor ligand activity, and appears to regulate antiviral defense, cell growth, and immune activation. It stimulates the production of a protein kinase and an oligoadenylate synthetase. (from LocusLink, Swiss-Prot, OMIM, and NCI)
Interferon Alfa-N1 definition: A highly purified alpha interferon produced by a human lymphoid cell line. Interferon alpha-n1 consists of multiple alpha interferon subtypes, at least two of which are glycosylated. In contrast, recombinant alpha interferons are individual non-glycosylated proteins produced from individual alpha interferon genes. Alpha interferons bind to specific cell-surface receptors, resulting in the transcription and translation of genes whose proteins have antiviral, antiproliferative, anticancer, and immune-modulating effects. (NCI04)
interferon definition: (in-ter-FEER-on) A biological response modifier (a substance that can improve the body's natural response to infection and disease). Interferons interfere with the division of cancer cells and can slow tumor growth. There are several types of interferons, including interferon-alpha, -beta, and -gamma. These substances are normally produced by the body. They are also made in the laboratory for use in treating cancer and other diseases.
Interferon definition: Human interferons have been classified into 3 groups: alpha, beta, and gamma. Both alpha- and beta-IFNs, previously designated type I, are acid-stable, but they differ immunologically and in regard to some biologic and physiochemical properties. The IFNs produced by virus-stimulated leukocytes (leukocyte IFNs) are predominantly of the alpha type. Those produced by lymphoblastoid cells are about 90% alpha and 10% beta. Induced fibroblasts produce mainly or exclusively the beta type. The alpha- and beta-IFNs differ widely in amino acid sequence. The gamma or immune IFNs, which are produced by T lymphocytes in response to mitogens or to antigens to which they are sensitized, are acid-labile and serologically distinct from alpha- and beta-IFNs. (from OMIM 147570)
Recombinant Interferon Alfa definition: A class of naturally-isolated or recombinant therapeutic peptides used as antiviral and anti-tumor agents. Alpha interferons are cytokines produced by nucleated cells (predominantly natural killer (NK) leukocytes) upon exposure to live or inactivated virus, double-stranded RNA or bacterial products. These agents bind to specific cell-surface receptors, resulting in the transcription and translation of genes containing an interferon-specific response element. The proteins so produced mediate many complex effects, including antiviral effects (viral protein synthesis); antiproliferative effects (cellular growth inhibition and alteration of cellular differentiation); anticancer effects (interference with oncogene expression); and immune-modulating effects (natural killer cell activation, alteration of cell surface antigen expression, and augmentation of lymphocyte and macrophage cytotoxicity). (NCI04)
recombinant interferon beta definition: A recombinant protein which is chemically identical to or similar to endogenous interferon beta with antiviral and anti-tumor activities. Endogenous interferons beta are cytokines produced by nucleated cells (predominantly natural killer cells) upon exposure to live or inactivated virus, double-stranded RNA or bacterial products. These agents bind to specific cell-surface receptors, resulting in the transcription and translation of genes with an interferon-specific response element. The proteins so produced mediate many complex effects, including antiviral (the most important being inhibition of viral protein synthesis), antiproliferative and immune modulating effects. The recombinant therapeutic forms of interferon beta are interferon beta 1-a and interferon beta 1-b. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40468&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40468&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C495" NCI Thesaurus)
Recombinant Interferon Beta definition: A recombinant protein which is chemically identical to or similar to endogenous interferon beta with antiviral and anti-tumor activities. Endogenous interferons beta are cytokines produced by nucleated cells (predominantly natural killer cells) upon exposure to live or inactivated virus, double-stranded RNA or bacterial products. These agents bind to specific cell-surface receptors, resulting in the transcription and translation of genes with an interferon-specific response element. The proteins so produced mediate many complex effects, including antiviral (the most important being inhibition of viral protein synthesis), antiproliferative and immune modulating effects. The recombinant therapeutic forms of interferon beta are interferon beta 1-a and interferon beta 1-b. (NCI05)
Interferon Beta-1A definition: A synthetic version of naturally occuring interferons that have immunomodulatory, antiviral and antiproliferative activities. It may exert antitumor activity by anti-angiogenic and cell differentiation activities. (NCI)
interferon binding definition: Interacting selectively with an interferon, a protein produced by the immune systems of many animals in response to a challenge by a foreign agent. [Wikipedia:Interferon]
interferon-gamma binding definition: Interacting selectively with interferon-gamma. Interferon-gamma is also known as type II interferon. [GOC:add, GOC:ai, ISBN:0126896631, PMID:15546383]
IFNA13 Gene definition: This gene plays a role in signal transduction and is involved in the immune response.
IFNA2 Gene definition: This gene plays a role in signal transduction, the immune response and positive regulation of apoptosis.
IL6 Gene definition: This gene is involved in immunoregulation processes by activating a cell-surface signaling assembly of proteins.
Interferon Activation definition: Through decreased degradation, or increased production or receptor binding, Interferon Activation involves induction of the activity of secreted proteins (alpha, beta, and gamma interferon types) that confer viral resistance, inhibit cell proliferation, enhance phagocytosis, augment NK cell activity, and show other immunomodulatory functions.
Interferon Suppression definition: Through increased degradation, or decreased production or receptor binding, Interferon Suppression involves interference with, or restraint of, the activities of secreted proteins (alpha, beta, and gamma interferon types) that confer viral resistance, inhibit cell proliferation, enhance phagocytosis, augment NK cell activity, and show other immunomodulatory functions.
Interferon Alpha definition: A class of interferon (leukocyte interferon) produced predominantly by B lymphocytes. Located in a cluster on 9p22 there are at least 13 functional genes and 1 pseudogene.
Interferon Alfa-N3 definition: A formulated therapeutic analog of the endogenous alpha interferon containing multiple interferon species with antiviral and antitumor properties. Interferons bind to specific cell-surface receptors, leading to the transcription and translation of genes with an interferon-specific response element, thereby inducing: antiviral effects (the most important being inhibition of viral protein synthesis); antiproliferative effects (including inhibition of cellular growth and alteration of cellular differentiation); anticancer effects (including interference with oncogene expression); and immune-modulating effects (including activation of natural killer cells, alteration of cell surface antigen expression, and augmentation of lymphocyte and macrophage cytotoxicity). (NCI04)
recombinant interferon alpha-1b definition: The non-glycosylated recombinant interferon alpha, subtype 1b, with immunostimulatory and antineoplastic activities. Alpha interferon-1b binds to specific cell-surface receptors, resulting in the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer, and immune-modulating effects. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=466520&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=466520&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C53411" NCI Thesaurus)
Recombinant Interferon Alpha-1b definition: The non-glycosylated recombinant interferon alpha, subtype 1b, with immunostimulatory and antineoplastic activities. Alpha interferon-1b binds to specific cell-surface receptors, resulting in the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer, and immune-modulating effects.