dict.md logo
Choose languages of interest
Leydig Cells definition: Steroid-producing cells in the interstitial tissue of the TESTIS. They are under the regulation of PITUITARY HORMONES; LUTEINIZING HORMONE; or interstitial cell-stimulating hormone. TESTOSTERONE is the major androgen (ANDROGENS) produced.
Leydig cell definition: epithelioid cells constituting the endocrine tissue of the testis, which elaborate androgens, chiefly testosterone.
Leydig Cell definition: Cells in the interstitial tissue of the testis that are believed to furnish the internal secretion of that gland. (MeSH)
Nephritis, Interstitial definition: Inflammation of the interstitial tissue of the kidney. This term is generally used for primary inflammation of KIDNEY TUBULES and/or surrounding interstitium. For primary inflammation of glomerular interstitium, see GLOMERULONEPHRITIS. Infiltration of the inflammatory cells into the interstitial compartment results in EDEMA, increased spaces between the tubules, and tubular renal dysfunction.
interstitial nephritis definition: diffuse or local inflammation and edema of the interstitial tissue of the kidney, including the tubules.
Pneumonia, Atypical Interstitial, of Cattle definition: A cattle disease of uncertain cause, probably an allergic reaction.
Theca Cells definition: The flattened stroma cells forming a sheath or theca outside the basal lamina lining the mature OVARIAN FOLLICLE. Thecal interstitial or stromal cells are steroidogenic, and produce primarily ANDROGENS which serve as precusors of ESTROGENS in the GRANULOSA CELLS.
Theca Cell definition: The connective tissue cells of the ovarian follicle. (MeSH)
Matrix Metalloproteinase 1 definition: A member of the metalloproteinase family of enzymes that is principally responsible for cleaving FIBRILLAR COLLAGEN. It can degrade interstitial collagens, types I, II and III.
Matrix Metalloproteinase-1 definition: Encoded by human MMP1 Gene (M10A Peptidase Family), 469-aa 54-kDa (precursor) secreted zinc- and calcium-binding Matrix Metalloproteinase-1 contains a hemopexin-like domain, an N-terminal catalytic domain, and a C-terminal substrate- and TIMP-binding domain. MMP1 undergoes autolytic cleavage to major forms 27-kDa (inactive) and 22-kDa (a collagenase activator). MMP1 preferentially cleaves interstitial collagens types I, II, and III at one site in the triple helical domain. MMP1 also cleaves collagens types VII and X and alpha-macroglobulins. (NCI)
Interstitial Fluid definition: The fluid in spaces between the tissue cells, constituting about 16% of the weight of the body; closely similar in composition to LYMPH. (On-Line Medical Dictionary [Internet]. University of Newcastle upon Tyne (UK): The CancerWEB Project, Academic Medical Publishing; c1997-2003 [cited 2003 May 1]. Available from: http://cancerweb.ncl.ac.uk/omd/.)
Lung Diseases, Interstitial definition: A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.
interstitial lung disease definition: heterogeneous group of noninfectious, nonmalignant disorders of the lower respiratory tract, affecting primarily the alveolar wall structures but also often involving the small airways and blood vessels of the lung parenchyma; may lead to respiratory insufficiency and death.
Cystitis, Interstitial definition: A condition with recurring discomfort or pain in the URINARY BLADDER and the surrounding pelvic region without an identifiable disease. Severity of pain in interstitial cystitis varies greatly and often is accompanied by increased urination frequency and urgency.
interstitial cystitis definition: condition of the bladder occurring predominantly in women, with an inflammatory lesion, usually in the vertex, and involving the entire thickness of the wall, appearing as a small patch of brownish red mucosa, surrounded by a network of radiating vessels; the lesions, may heal superficially, and are notoriously difficult to detect; typically, there is urinary frequency and pain on bladder filling and at the end of micturition.
Benign Leydig Cell Tumor definition: A Leydig cell tumor which does not recur or metastasize. Morphologically, there is no evidence cellular atypia, increased mitotic activity, necrosis, or vascular invasion.
interstitial definition: pertaining to or situated between parts of or in the interspaces of a tissue.
interstitial matrix definition: A type of extracellular matrix found in interstitial connective tissue, characterized by the presence of fibronectins, proteoglycans, and types I, III, V, VI, VII and XII collagens. [PMID:8450001]
MMP1 Gene definition: This gene plays a role in cell migration, inflammation and the regulation of extracellular matrix remodeling.
Interstitial Cells of Cajal definition: c-Kit positive cells related to smooth muscle cells that are intercalated between the autonomic nerves and the effector smooth muscle cells of the gastrointestinal tract. Different phenotypic classes play roles as pacemakers, mediators of neural inputs, and mechanosensors.
Interstitial Cell of Cajal definition: A specialized cell found throughout the gastrointestinal tract. These cells are essential for normal gastrointestinal motility by functioning as the pacemaker cells in gastrointestinal muscles. They mediate or transduce inputs from enteric motor nerves to the smooth muscle syncytium.
interstitial cell of Cajal definition: interstitial gastrointestinal cell serving a pacemaker function.
INTERSTITIAL definition: Administration to or in the interstices of a tissue. (FDA)
Interstitial Route of Administration definition: Drug administration to or in the interstices of a tissue.
Interstitial Cell definition: An interstitial cell is a cell that is part of the connective and soft tissues.
Injection, interstitial definition: Injection, interstitial
Alport syndrome definition: hereditary disorder characterized by progressive sensorineural hearing loss, progressive pyelonephritis or glomerulonephritis, and, occasionally, ocular defects; transmitted as an autosomal dominant or X-linked trait.
Alport Syndrome definition: A genetic syndrome usually inherited as an X-link trait. It is caused by abnormalities in the COL4A5 gene. It affects males more often than females and is characterized by hematuria, progressive renal insufficiency, hearing loss, and ocular abnormalities.
Alport syndrome (AS, ATS) definition: A genetically heterogenous disorder characterized by kidney abnormalities with hematuria and proteinuria, sensorineural hearing loss, and eye abnormalities. Two main genetically distinct forms are recognized: An X-linked dominant form (MIM 301050) with additional features including mental retardation, dysmorphic facies with midfacial hypoplasia, elliptocytosis and smooth muscle tumors; and an autosomal recessive form (OMIM 203780). Variants of Alport syndrome without mental retardation include: Alport syndrome with leukocyte inclusions and macrothrombocytopenia (transmitted as an autosomal dominant trait) Synonyms: Fechtner syndrome (named after a patient) Sebastian platelet syndrome (named after a patient) macrothrombocytopathy-deafness-nephritis-leukocyte inclusions syndrome (OMIM 153640) Alport syndrome with macrothrombocytopenia (transmitted as an autosomal dominant trait) Synonyms: Epstein syndrome hereditary macrothrombocytopathia-nephritis-deafness syndrome macrothrombocytopathy-nephritis-deafness syndrome thrombocytopenia-macrothrombocytopathia-nephritis-defames syndrome (OMIM 153650) hereditary nephropathy-deafness syndrome (transmitted as an autosomal dominant trait) Synonym: hereditary nephropathy-sensorineural hearing loss syndrome (OMIM 104200) Alport syndrome with abnormal collagen of basement membrane (transmitted as an X-linked trait) (OMIM 303630)
Interstitial Disease definition: A disease occurring chiefly in the connective-tissue framework of an organ.
interstitiell definition: [1] Medizin: in den Zwischenräumen liegend, z. B. von Geweben, Gewebeflüssigkeiten; im Interstitium liegend oder sich ereignend [2] vorgeschriebene Zwischenzeit zwischen dem Empfang zweier geistlicher Weihen (katholisch)