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Definition
 
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Giant Lymph Node Hyperplasia definition: Large benign, hyperplastic lymph nodes. The more common hyaline vascular subtype is characterized by small hyaline vascular follicles and interfollicular capillary proliferations. Plasma cells are often present and represent another subtype with the plasma cells containing IgM and IMMUNOGLOBULIN A.
Castleman's disease definition: A rare disorder in which noncancerous growths develop in lymph node tissue.
chronic lymphocytic leukemia definition: chronic leukemia characterized by morphologically mature but immunologically less mature lymphocytes; manifested by an abnormal accumulation of these cells in blood, bone marrow, and lymphatic tissue.
chronic lymphocytic leukemia definition: A slowly progressing disease in which too many white blood cells (called lymphocytes) are found in the body.
Leukemia, Lymphocytic, Chronic, B-Cell definition: A chronic leukemia characterized by abnormal B-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (CLL); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease.
Chronic Lymphocytic Leukemia definition: The most common type of chronic lymphoid leukemia. It comprises 90% of chronic lymphoid leukemias in the United States. Morphologically, the neoplastic cells are small, round B-lymphocytes. This type of leukemia is not considered to be curable with available therapy. (WHO, 2001)
lymphocytic leukemia definition: leukemia associated with hyperplasia and overactivity of the lymphoid tissue; there are increased numbers of circulating malignant lymphocytes and lymphoblasts.
Leukemia, Lymphoid definition: Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts.
Lymphoid Leukemia definition: A malignant lymphocytic neoplasm of B-cell or T-cell lineage involving primarily the bone marrow and the peripheral blood. This category includes precursor or acute lymphoblastic leukemias and chronic leukemias.
acute lymphocytic leukemia definition: acute leukemia in which lymphoblasts and their progenitor cells predominate; the most common childhood cancer and accounts for 20 percent of adult acute leukemia; common ALL antigen (CALLA) expressed in most cases.
acute lymphocytic leukemia definition: A quickly progressing disease in which too many immature white blood cells called lymphoblasts are found in the blood and bone marrow.
Acute Lymphoblastic Leukemia definition: Leukemia with an acute onset, characterized by the presence of lymphoblasts in the bone marrow and the peripheral blood. It includes the acute B lymphoblastic leukemia and acute T lymphoblastic leukemia.
Leukemia, Lymphocytic, Acute, L1 definition: When the disease process is confined to a mass lesion with no or minimal evidence of blood and less than 25% marrow involvement, the diagnosis is lymphoblastic lymphoma; with blood and greater than 25% marrow involvement, ALL is the appropriate term.
Childhood Acute Lymphoblastic Leukemia definition: An acute lymphoblastic leukemia occurring during childhood. The majority of cases are B-acute lymphoblastic leukemias. Approximately 15% of the cases are T-acute lymphoblastic leukemias.
Lymphatic Irradiation definition: External or interstitial irradiation to treat lymphomas (e.g., Hodgkin's and non-Hodgkin's lymphomas) and lymph node metastases and also some autoimmune diseases, such as rheumatoid arthritis.
Lymphoid Tissue definition: Specialized tissues that are components of the lymphatic system. They provide fixed locations within the body where a variety of LYMPHOCYTES can form, mature and multiply. The lymphoid tissues are connected by a network of LYMPHATIC VESSELS.
lymphatic tissue definition: specialized tissues that are components of the lymphatic system, providing fixed locations within the body where a variety of lymphocytes can form, mature, and multiply.
Lymphoid Tissue definition: Tissue characterized by the presence of large numbers of lymphocytes in different stages of transformation. Connective tissue cells including fibroblasts and macrophages may be present. Lymphoid tissue is framed by a network of reticular fibers and may be diffuse, or densely aggregated.
Lymphomatoid Granulomatosis definition: An angiocentric and angiodestructive lymphoproliferative disorder primarily involving the lungs. It is caused by an Epstein-Barr virus-induced transformation of the B-cells, in a T-cell rich environment. Clinically and pathologically it resembles EXTRANODAL NK-T-CELL LYMPHOMA.
lymphomatoid granulomatosis definition: Destructive growth of lymph cells, usually involving the lungs, skin, kidneys, and central nervous system. Grades I and II are not considered cancerous, but grade III is considered a lymphoma.
Lymphomatoid Granulomatosis definition: An angiocentric and angiodestructive lymphoproliferative disease involving extranodal sites, comprised of Epstein-Barr virus (EBV)-positive B-cells admixed with reactive T-cells. Incidence is higher among adult males; patients with a history of immunodeficiency are at increased risk. The most common site of involvement is the lung; other common sites include brain, kidney, liver, and skin. Morphologically, three grades are recognized: grade I, II, and III. Grade III lymphomatoid granulomatosis should be approached clinically as a subtype of diffuse large B-cell lymphoma.
Angiocentric Immunoproliferative Lesion definition: A neoplastic lymphoproliferative process characterized by an angiocentric arrangement of the tumor cells which is associated with angiodestruction. It includes lymphomatoid granulomatosis which is a lymphoproliferative lesion derived from mature B-lymphocytes and cases of extranodal NK/T-cell lymphomas of nasal type.
Acute Lymphoblastic Leukemia in Remission definition: Acute lymphoblastic leukemia not growing; responding to treatment.
Chronic Lymphocytic Leukemia in Remission definition: Chronic lymphocytic leukemia not growing, responding to treatment.
B Lymphoid Tyrosine Kinase definition: Encoded by the BLK gene, p55-BLK is a non-receptor protein tyrosine kinase member of the SRC protooncogene family and, on the basis of its preferential expression in B-lymphoid cells, it may function in a signal transductory pathway specific to this lineage. Expression of BLK in immature T-cells suggests that it may play an important role in thymopoiesis. The protein has SH3, SH2, and catalytic domains that contain SRC tyrosine kinase family consensus sequences. (from OMIM 191305 and NCI)
B Lymphoid Tyrosine Kinase definition: A protein tyrosine kinase activated within seconds after crosslinking the mIg complex on B cells.
Hematopoietic and Lymphoid Cell Neoplasm definition: A neoplasm arising from hematopoietic cells found in the bone marrow, peripheral blood, lymph nodes and spleen (organs of the hematopoietic system). Hematopoietic cell neoplasms can also involve other anatomic sites (e.g. central nervous system, gastrointestinal tract), either by metastasis, direct tumor infiltration, or neoplastic transformation of extranodal lymphoid tissues. The commonest forms are the various types of leukemia, Hodgkin and non-Hodgkin lymphomas, and myelodysplastic syndromes.
Gut-Associated Lymphoid Tissue definition: Non-encapsulated accumulations of lymphoid tissue in the alimentary tract that form a secretory immune system containing cells committed to IgA or IgE synthesis; It includes Peyer's patches and the lymphoid tissue which is present throughout the gastrointestinal mucosa.
gut associated lymphoid tissue definition: non-encapsulated accumulations of lymphoid tissue in the alimentary tract that form a secretory immune system containing cells committed to IgA or IgE synthesis; include tonsils, Peyer's patches, lamina propria, and appendix.
Lymphocytic Neoplasm definition: A neoplasm composed of a lymphocytic cell population which is usually malignant (clonal) by molecular genetic and/or immunophenotypic analysis. Lymphocytic neoplasms include Hodgkin's and Non-Hodgkin's lymphomas, acute and chronic lymphocytic leukemias, and plasma cell neoplasms. - 2003
Mucosa-Associated Lymphoid Tissue definition: Lymphoid tissue located beneath the mucosal epithelia of those mucosal surfaces that have contact with the external environment, such as the respiratory, digestive, and urinary systems. MALT consists of a collection of predominantly small lymphocytes, fewer larger, transformed lymphocytes, and plasma cells. It protects the body from pathogens that enter via the mucosa. MALT gives rise to a distinctive type of B-cell lymphoma that usually follows an indolent clinical course.
Chemokine CCL21 definition: A CC-type chemokine with specificity for CCR7 RECEPTORS. It has activity towards DENDRITIC CELLS and T-LYMPHOCYTES.
Small Inducible Cytokine A21 definition: This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 (CCR7) that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). (from LocusLink)
Small Inducible Cytokine A21 definition: Secondary Lymphoid Tissue Chemokine is an endothelial CC (beta) subfamily chemokine expressed preferentially in lymph node tissue. Unlike other CC chemokines, SLC is specifically chemotactic for Th1 lymphocytes, and for dendritic cells. The ability of SLC to chemoattract both Th1 lymphocytes and dendritic cells formed the rationale to evaluate this chemokine in cancer immunotherapy. (from OMIM 602737 and NCI)
lymphomatous thyroiditis definition: progressive enlargement of the thyroid gland, often associated with hypothyroidism.
Hashimoto Disease definition: Chronic autoimmune thyroiditis, characterized by the presence of high serum thyroid AUTOANTIBODIES; GOITER; and HYPOTHYROIDISM.
Adult Acute Lymphoblastic Leukemia definition: An acute lymphoblastic leukemia occurring during adulthood.
Protein Tyrosine Phosphatase, Non-Receptor Type 22 definition: A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of an N-terminal catalytic domain and a C-terminal PROLINE-rich domain. The phosphatase subtype is predominantly expressed in LYMPHOCYTES and plays a key role in the inhibition of downstream T-LYMPHOCYTE activation. Polymorphisms in the gene that encodes this phosphatase subtype are associated with a variety of AUTOIMMUNE DISEASES.
BLOOD AND LYMPHATIC SYSTEM DISORDERS definition: Any deviation from the normal structure or function of the blood or lymphatic system that is manifested by a characteristic set of symptoms and signs. (NCI)
Hematopoietic and Lymphoid System Disorder definition: Any deviation from the normal structure or function of the blood or lymphatic system that is manifested by a characteristic set of symptoms and signs.
Bronchus-Associated Lymphoid Tissue definition: Lymphoid tissue located in the bronchi.
BLK Gene definition: This gene is involved in signal transduction in B lymphocytes.
PTPN22 Gene definition: This gene plays a role in the regulation of the immune system, the development of autoimmunity and the cellular response to pathogens.
Hematopoietic and Lymphoid Cell definition: One of the cells of the blood, a leukocyte or erythrocyte. SYN blood corpuscle.
Hematopoietic and Lymphoid System Neoplasm definition: Neoplasms of the hematopoietic system, including hematopoietic cell neoplasms (e.g. leukemias, lymphomas) and non-hematopoietic cell neoplasms that can affect the hematopoietic system (e.g. lymph node and splenic sarcomas). --2003
Precursor Cells, B-Lymphoid definition: Lymphocyte progenitor cells that are restricted in their differentiation potential to the B lymphocyte lineage. The pro-B cell stage of B lymphocyte development precedes the pre-B cell stage.
Immature B-Lymphocyte definition: A B-lymphocyte derived from a Pre B lymphocyte. It develops in bone marrow then exit via the central sinus. It goes through the vascular system to the spleen. It does not proliferate and differentiate in response to antigen, but instead responds to antigen by negative selection resulting in subsequent immune system tolerance to that antigen.
lymphoid definition: (LIM-foyd) Referring to lymphocytes, a type of white blood cell. Also refers to tissue in which lymphocytes develop.
hemopoietic or lymphoid organ development definition: The process whose specific outcome is the progression of any organ involved in hemopoiesis or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation. [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
Crohn Disease-like Reaction definition: A distinctive Crohn's disease-like reaction (CLR) consisting of discrete lymphoid aggregates, some with germinal centers, and surrounding stellate fibrosis commonly found around colorectal adenocarcinomas in the absence of clinical or pathologic evidence of prior Crohn's disease.
Lymphoid Progenitor Cells definition: Stem cells from which B-LYMPHOCYTES; T-LYMPHOCYTES; NATURAL KILLER CELLS; and some DENDRITIC CELLS derive.
Precursor Cells, T-Lymphoid definition: Lymphocyte progenitor cells that are restricted in their differentiation potential to the T lymphocyte lineage.
Precursor Cell Lymphoblastic Leukemia-Lymphoma definition: A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.