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biological response modifier definition: a diversity of reagents employed for nonspecific active immunization; used to enhance the immune response; 4 major groups: bacterial products, synthetic molecules, cytokines, and hormones.
Immunomodulating Agent definition: Substances or procedures that enhance the host's ability to inhibit tumorigenesis or tumor progression or that increase the differential between tumor and host susceptibility to therapeutic agents. Thus BRMs can be preventive (vaccines, vitamins) or therapeutic (interferon, monoclonal antibodies, hyperthermia, gene therapy.) Standard, nonspecific therapies such as drugs and radiation are excluded but radiation delivered via antibodies would be included since it exploits a differential susceptibility of tumor and host.
Lymphokines definition: Soluble protein factors generated by activated lymphocytes that affect other cells, primarily those involved in cellular immunity.
lymphokine definition: soluble mediators of immune responses that are not antibodies or complement components and that are released by sensitized lymphocytes on contact with antigen.
Lymphokine definition: A general term for soluble mediators of immune responses that are not antibodies or complement components and that are released by sensitized lymphocytes on contact with antigen.
Inflammation Mediators definition: The endogenous compounds that mediate inflammation (AUTACOIDS) and related exogenous compounds including the synthetic prostaglandins (PROSTAGLANDINS, SYNTHETIC).