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biological response modifier definition: a diversity of reagents employed for nonspecific active immunization; used to enhance the immune response; 4 major groups: bacterial products, synthetic molecules, cytokines, and hormones.
Immunomodulating Agent definition: Substances or procedures that enhance the host's ability to inhibit tumorigenesis or tumor progression or that increase the differential between tumor and host susceptibility to therapeutic agents. Thus BRMs can be preventive (vaccines, vitamins) or therapeutic (interferon, monoclonal antibodies, hyperthermia, gene therapy.) Standard, nonspecific therapies such as drugs and radiation are excluded but radiation delivered via antibodies would be included since it exploits a differential susceptibility of tumor and host.
Biological Therapy definition: Treatment of diseases with biological materials or biological response modifiers, such as the use of GENES; CELLS; TISSUES; organs; SERUM; VACCINES; and humoral agents.
biotherapy definition: (by-o-LAHJ-i-kul...)Treatment to stimulate or restore the ability of the immune system to fight infections and other diseases. Also used to lessen side effects that may be caused by some cancer treatments.
Biological Therapy definition: A form of treatment that implies the administration of substances which produce a biological reaction in the organism thus enhancing or restoring the host immune response, modifying the behavior of cancer cells, blocking the pathways of cell neoplastic transformation and tumor ability to metastasize, or facilitating the repair of cells damaged by aggressive forms of cancer treatment. It includes the use of sera, antitoxins, vaccines, genes, cells, tissues, and organs.
Effect Modifiers (Epidemiology) definition: Factors that modify the effect of the putative causal factor(s) under study.
Estrogen Antagonists definition: Compounds which inhibit or antagonize the action or biosynthesis of estrogenic compounds.
antiestrogen definition: A substance that blocks the activity of estrogens, the family of hormones that promote the development and maintenance of female sex characteristics.
estrogen inhibitor definition: substances or agents which suppress, prevent or oppose the action of estrogen.
Antiestrogen definition: Substances that inhibit or antagonize the biosynthesis or biologic effects of estrogens by either antagonizing the responsiveness of estrogen sensitive tissues or competing with their binding sites.
Radiation-Protective Agents definition: Drugs used to protect against ionizing radiation. They are usually of interest for use in radiation therapy but have been considered for other, e.g. military, purposes.
radioprotective agent definition: drugs used to protect against ionizing or other forms of radiation.
Unclassified definition: Not arranged or included in any specific grouping.
Biological Response Modifiers Program definition: A program set up to establish cooperative agreements for Clinical Trials of Cancer Therapy with Biological Response Modifiers (CATBRMs) and to develop novel approaches for such therapy. Funding is provided to foster innovative clinical trials of BRMs by peer-reviewed groups of highly experienced clinical and preclinical investigators who have the unique technical capabilities to study new agents in early clinical trials and to address hypothesis-driven issues of mechanisms of action.
Miscellaneous Biologic Response Modifier definition: Biologic response modifiers with non-specific classification based on mechanism of action, therapeutic use, or chemical properties. (NCI)
BLOOD PRODUCTS/MODIFIERS/VOLUME EXPANDERS definition: INCLUDES: IRON/BLOOD FORMATION (BL400) PRODUCTS CONTAINING IRON SALTS AS SINGLE INGREDIENT OR IN COMBINATION WITH ASCORBIC ACID,CYANOCOBALAMIN,FOLIC ACID, OR INTRINSIC FACTOR
HORMONES/SYNTHETICS/MODIFIERS definition: INCLUDES: PARATHYROID (HS600) INCLUDES ALL PRODUCTS AFFECTING CALCIUM REGULATION, EXCEPT VITAMIN D AND ITS ANALOGUES COMBINATIONS: HORMONES,OTHER (HS950) INCLUDES ANDROGEN/ESTROGEN COMBINATION PRODUCTS AND THOSE NEC EXCLUDES: ANTI-INFLAMMATORY TOPICAL PRODUCTS SEE: DERMATOLOGICAL AGENTS (DE000), NASAL AND THROAT, TOPICAL (NT100), OPHTHALMIC AGENTS (OP100), OTIC AGENTS (OT000) AND RECTAL,LOCAL (RS000)