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Macrophages definition: The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
macrophage definition: mononuclear phagocytes found in tissue.
macrophage definition: A type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cells.
Monocytes definition: Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.
monocyte definition: large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood and tissues where they develop into macrophages; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.
monocyte definition: A type of white blood cell.
Monocyte definition: Large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.
Plasminogen Activator Inhibitor 2 definition: Member of the serpin family of proteins. It inhibits both the tissue-type and urokinase-type plasminogen activators.
Plasminogen Activator Inhibitor-2 definition: Expressed in keratinocytes, monocytes, macrophages, placenta, and trophoblast by human SERPINB2 Gene (Serpin Family), 415-aa 47-kDa (predicted, unglycosylated) cytoplasmic Plasminogen Activator Inhibitor 2 is a specific inhibitor of urokinase-type plasminogen activator thought to regulate plasminogen activation in the extravascular compartment and to have a possible role in placental maintenance or embryo development. The primary intracellular distribution of SERPINB2 may also indicate a regulatory role in a protease-dependent cellular process such as apoptosis. (NCI)
Plasminogen Activator Inhibitor-2 definition: Plasminogen Activator Inhibitor-2 is a member of the serpin superfamily that inhibits both tissue-type and urokinase-type plasminogen activators. Inhibitors of plasminogen activators classify in four distinct groups: PAI1 type from endothelial cells; PAI2 type from placenta, monocytes, and macrophages; urinary inhibitor; and protease-nexin-I. PAI2 (monocyte Arg-serpin) also belongs to the serine protease subfamily in which target specificity is determined by an Arg residue at its reactive center: Met/Val for elastase, Leu for kinase, and Arg for thrombin. PAI2 may be involved in many processes; its role in placenta, pregnancy plasma, skin, and inflammatory conditions remain to be established. PAI2 is thought to regulate plasminogen activation in extravascular compartments. High levels are found in keratinocytes, monocytes, and the trophoblast. (from OMIM 173390 and NCI)
Monocytes, Activated Killer definition: Monocytes made cytotoxic by IN VITRO incubation with CYTOKINES, especially INTERFERON-GAMMA. The cells are used for ADOPTIVE IMMUNOTHERAPY in cancer patients.
Monocyte, Activated Killer definition: Monocytes made cytotoxic by ex vivo incubation with cytokines, especially interferon-gamma. AKM cells are used for adoptive immunotherapy in cancer patients. (MeSH)
Antigens, CD14 definition: Glycolipid-anchored membrane glycoproteins expressed on cells of the myelomonocyte lineage including monocytes, macrophages, and some granulocytes. They function as receptors for the complex of lipopolysaccharide (LPS) and LPS-binding protein.
Monocyte Differentiation Antigen CD14 definition: Monocyte Differentiation Antigen CD14 (375 aa, 40 kD) is a cell fate protein that is encoded by the human CD14 gene and has a role in apoptosis and phagocytosis.
Monocyte Differentiation Antigen CD14 definition: CD14 is a single-copy gene encoding 2 protein forms: a 50- to 55-kD glycosylphosphatidylinositol-anchored membrane protein (mCD14) and a monocyte or liver-derived soluble serum protein (sCD14) that lacks the anchor. Both molecules are critical for lipopolysaccharide (LPS)-dependent signal transduction, and sCD14 confers LPS sensitivity to cells lacking mCD14. Increased sCD14 levels are associated with inflammatory infectious diseases and high mortality in gram-negative shock. (OMIM)
CD14 molecule definition: CD antigen expressed on surface of monocytes, macrophages, eosinophils, neutrophils; lipopolysaccharide receptor; signals production of tumor necrosis factor.
Chemokine CCL2 definition: A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. It is produced by LEUKOCYTES of both monocyte and lymphocyte lineage and by FIBROBLASTS during tissue injury. It has specificity for CCR2 RECEPTORS.
monocyte chemoattractant protein 1 definition: attracts monocytes and memory T lymphocytes to the exclusion of other leukocytes such as neutrophils; it has been hypothesized that it plays a pathogenic role in a variety of diseases having a monocyte inflammatory component, such as atherosclerosis.
Small Inducible Cytokine A2 definition: A chemokine that is a chemoattractant for human monocytes and may also cause cellular activation of specific functions related to host defense. It is produced by leukocytes of both monocyte and lymphocyte lineage and by fibroblasts during tissue injury. (MeSH Definition)
Small Inducible Cytokine A2 definition: This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. (from LocusLink)
Monocyte Count definition: The determination of the number of monocytes in a blood sample.
Monocytes definition: A measurement of the monocytes per unit of a biological specimen.
Monocyte Chemoattractant Proteins definition: Chemokines that are chemoattractants for monocytes. These CC chemokines (cysteines adjacent) number at least three including CHEMOKINE CCL2.
Burkitt Lymphoma Receptor 1 Protein definition: Burkitt lymphoma receptor protein 1 (372 aa, 42 kD) is a cell motility protein that is encoded by the human BLR1 gene and has roles in cell motility and signal transduction.
Burkitt Lymphoma Receptor 1 Protein definition: A cytokine receptor that binds to BLC. Burkitt lymphoma receptor 1 exerts possibly a regulatory function in Burkitt lymphoma lymphomagenesis and/or B-cell differentiation. It is a potential candidate for cell-cell interaction, and activation of mature B- lymphocytes in lymphatic tissues. (Swissprot)
Chemokine CCL7 definition: A monocyte chemoattractant protein that has activity towards a broad variety of immune cell types. Chemokine CCL7 has specificity for CCR1 RECEPTORS; CCR2 RECEPTORS; and CCR5 RECEPTORS.
Small Inducible Cytokine A7 definition: Small Inducible Cytokine A7, encoded by the CCL7 gene, is a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. (from LocusLink)
Chemokine CCL8 definition: A monocyte chemoattractant protein that attracts MONOCYTES; LYMPHOCYTES; BASOPHILS; and EOSINOPHILS. Chemokine CCL8 has specificity for CCR3 RECEPTORS and CCR5 RECEPTORS.
Small Inducible Cytokine A8 definition: This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection. (from LocusLink)
Small Inducible Cytokine A8 definition: Chemokines, a family of small cytokines, attract leukocytes and possess various immunomodulating functions. CC chemokines influence mononuclear cell types. Human Macrophage Chemoattractant Protein-2 is a chemotactic factor for monocytes, lymphocytes, basophils and eosinophils. This monomer or homodimer can bind heparin. Its expression is induced by interferon gamma, mitogens, and IL-1. (from OMIM 602283, Swiss-Prot P80075, and NCI)
Small Inducible Cytokine A13 definition: Induced by IL-1 and TNF-alpha, widely expressed, and encoded by human CCL13 Gene (Intercrine Beta Family), 98-aa 11-kD (precursor) Small Inducible Cytokine A13 is a secreted chemotactic factor for monocytes, lymphocytes, basophils, and eosinophils that signals through CCR2B and CCR3 receptors and is involved in immunoregulatory and inflammatory processes. The protein can bind heparin and isoforms MCP-4, (LA)MCP-4, and (FNPQGLA)MCP-4 exist. CCL13 may be involved in atherosclerosis. (NCI)
Reagents, Immunoassay, Immunology, Cell Typing, Monoclonal Antibody, Monocyte definition: Immunology reagents including monoclonal antibodies that are used in immunologic tests which contribute in typing blood monocytes, a type of cell of the mononuclear phagocyte system of bone marrow origin, by identifying their antigens (e.g., CD13, CD14, CD33). Monocytes migrate from the blood into various tissues and transform in macrophages, thus the antigens of both types of cells are usually similar. These tests are used to differentiate among a heterogeneous group of neoplasms.
monocyte activation definition: The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. [GOC:mgi_curators, ISBN:0781735149 "Fundamental Immunology"]
monocyte differentiation definition: The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte. [GOC:mah]
monocyte chemotaxis definition: The movement of a monocyte in response to an external stimulus. [GOC:add, PMID:11696603, PMID:15173832]
Immature Monocyte definition: A cell derived from a myeloid stem cell. It is the representation of one stage of monocyte development.
CCL13 Gene definition: This gene is involved in the regulation of inflammatory responses.
CCL7 Gene definition: This gene plays a role in extracellular matrix modulation and inflammatory processes.
CCL8 Gene definition: This gene is involved in the modulation of immune functions.
CCL2 Gene definition: This gene is involved in inflammatory processes and disease development.
CD14 Gene definition: This gene plays a role in apoptosis and in ligand-binding interactions.
SERPINB2 Gene definition: This gene plays a role in the regulation of transcription, cell proliferation and cell differentiation. It is also involved in the inhibition of apoptosis.
Recombinant Human Monocyte Chemoattractant Protein-2 definition: A recombinant agent, chemically identical or similar to the endogenous small inducible cytokine A8 (MCP-2). This agent is a member of the Cys-Cys chemokine family, with potent chemoattractant effect for monocytes, basophils and T lymphocytes and antiviral activity. MCP-2 is a ligand for CC chemokine receptor 5 (CCR5) on CD4+ lymphocytes, and competitively block R5 HIV-1 cellular entry via interaction with CCR5, through direct interference with HIV-1 gp120 binding. This agent induces a robust, pertussis toxin-sensitive calcium flux in primary lymphocytes.
Recombinant Monocyte Chemoattractant Protein-1 definition: A recombinant therapeutic agent which is chemically identical to or similar to endogenous human monocyte chemoattractant protein-1, a member of the CC chemokine family which is chemotactic for monocytes. (NCI04)
monocyte antigen processing and presentation definition: The process by which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. [GOC:add, PMID:11200054]
Monocyte to Leukocyte Ratio definition: The determination of the ratio of monocytes compared to leukocytes in a blood sample. The measurement may be expressed as a ratio or percentage.
Monocytes/Leukocytes definition: A relative measurement (ratio or percentage) of the monocytes to leukocytes in a biological specimen.
Monocyte-Macrophage Precursor Cells definition: Parent cells in the lineage that gives rise to MONOCYTES and MACROPHAGES.
monocyte aggregation definition: The adhesion of one monocyte to one or more other monocytes via adhesion molecules. [GOC:sl, PMID:12972508]
 
 
frFrench
monocyte definition: Cellule sanguine de la famille des leucocytes qui évoluent en macrophages.