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Leukocytes, Mononuclear definition: Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules.
agranulocyte definition: (A-gran-yoo-lo-SITE) A type of white blood cell; monocytes and lymphocytes are agranulocytes.
Non-Granular Leukocyte definition: Mature lymphocytes andmonocytes transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules. (MeSH)
reticuloendothelial system definition: mononuclear phagocyte system (monocytes and macrophages) plus the vascular endothelium and the reticular and dendritic cells of lymphoid organs; whether this heterogeneous collection can still be considered a "system" is controversial.
Mononuclear Phagocyte System definition: Mononuclear cells with pronounced phagocytic ability that are distributed extensively in lymphoid and other organs. It includes MACROPHAGES and their precursors; PHAGOCYTES; KUPFFER CELLS; HISTIOCYTES; DENDRITIC CELLS; LANGERHANS CELLS; and MICROGLIA. The term mononuclear phagocyte system has replaced the former reticuloendothelial system, which also included less active phagocytic cells such as fibroblasts and endothelial cells. (From Illustrated Dictionary of Immunology, 2d ed.)
Reticuloendothelial System definition: A widely distributed collection of both free and fixed macrophages derived from bone marrow precursor cells by way of monocytes; their substantial phagocytic activity is mediated by immunoglobulin and the serum complement system. In both connective and lymphoid tissue, they may occur as free and fixed macrophages; in the sinusoids of the liver, as Kupffer cells; in the lung, as alveolar macrophages; and in the nervous system, as microglia.
Synovial fluid: mononuclear predominance definition: WHAT: Synovial fluid Synovial Fluid: a classification of joint fluid obtained by sterile arthrocentesis, according to its characteristics noted by certain laboratory examinations. WHY: Type I synovial fluid (non-inflammatory) often occurs in degenerative joint disease, trauma, osteochondritis dissecans, osteochondromatosis, neuropathic arthropathy, subsiding or early inflammation, hypertrophic osteoarthropathy, and pigmented villonodular synovitis. Type II synovial fluid (inflammatory) often occurs in rheumatoid arthritis, acute crystal-induced synovitis (gout and pseudogout), Reiter's syndrome, ankylosing spondylitis, psoriatic arthritis, arthritis accompanying ulcerative colitis and regional enteritis, rheumatic fever, systemic lupus erythematosus, and progressive systemic sclerosis (scleroderma). Type III synovial fluid (septic) often occurs in bacterial infections. HOW: Normal -- WBCs <200/cu mm, PMNs <25%, culture negative, glucose in mg/dl nearly equal to that of blood. Type I (Noninflammatory) -- WBCs 200-2,000/cu mm, PMNs <25%, culture negative, glucose in mg/dl nearly equal to blood. Type II (Inflammatory) -- WBCs 2,000-100,000/cu mm, PMNs >=50%, culture negative, glucose >25mg/dl and lower than blood. Type III (Septic) -- WBCs >100,000/cu mm, PMNs >=75%, culture often positive, glucose <25mg/dl and much lower than blood. REFS: "Examination of Joint Fluid", Primer on the Rheumatic Diseases, 7th ed. New York, N.Y.: The Arthritis Foundation, 1973. DN19234-1.
Synovial fluid mononuclear, % definition: WHAT: Synovial fluid Synovial Fluid: a classification of joint fluid obtained by sterile arthrocentesis, according to its characteristics noted by certain laboratory examinations. WHY: Type I synovial fluid (non-inflammatory) often occurs in degenerative joint disease, trauma, osteochondritis dissecans, osteochondromatosis, neuropathic arthropathy, subsiding or early inflammation, hypertrophic osteoarthropathy, and pigmented villonodular synovitis. Type II synovial fluid (inflammatory) often occurs in rheumatoid arthritis, acute crystal-induced synovitis (gout and pseudogout), Reiter's syndrome, ankylosing spondylitis, psoriatic arthritis, arthritis accompanying ulcerative colitis and regional enteritis, rheumatic fever, systemic lupus erythematosus, and progressive systemic sclerosis (scleroderma). Type III synovial fluid (septic) often occurs in bacterial infections. HOW: Normal -- WBCs <200/cu mm, PMNs <25%, culture negative, glucose in mg/dl nearly equal to that of blood. Type I (Noninflammatory) -- WBCs 200-2,000/cu mm, PMNs <25%, culture negative, glucose in mg/dl nearly equal to blood. Type II (Inflammatory) -- WBCs 2,000-100,000/cu mm, PMNs >=50%, culture negative, glucose >25mg/dl and lower than blood. Type III (Septic) -- WBCs >100,000/cu mm, PMNs >=75%, culture often positive, glucose <25mg/dl and much lower than blood. REFS: "Examination of Joint Fluid", Primer on the Rheumatic Diseases, 7th ed. New York, N.Y.: The Arthritis Foundation, 1973. DN19234-1.
mononuclear iron electron carrier definition: OBSOLETE. A mononuclear iron entity that serves as an electron acceptor and electron donor in an electron transport system. [GOC:ai]
Peripheral Blood Mononuclear Cell definition: A monocyte found in the general circulation.
Mononuclear definition: Possessing a single nucleus.
gp100-Pulsed Peripheral Blood Mononuclear Cell definition: Peripheral blood lymphocytes (PBL) harvested from host blood and stimulated in vitro with tumor-specific gp 100 antigen. 'Pulsing' PBL with gp100, a tumor associated antigen (TAA) commonly expressed by melanoma cells, may increase melanoma-reactive cytotoxic lymphocytes (CTL) in the PBL cell population. Autologous gp100-pulsed PBL have been administered to melanoma patients in order to augment cytotoxic immune responses to melanoma. (NCI04)
Indium In 111-Labeled Autologous Peripheral Blood Mononuclear Cells definition: A preparation of autologous peripheral blood mononuclear cells (PBMCs) radiolabeled with indium In 111 with radioisotopic activity. Autologous PBMCs are isolated, expanded ex vivo, radiolabeled with indium In 111, and then infused back into the patient. Gamma scintigraphy may then be used to image gamma ray-emitting indium In 111 PBMCs localized in lymphoma tissue.
mononuclear cell proliferation definition: The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form. [GOC:add]
regulation of mononuclear cell proliferation definition: Any process that modulates the frequency, rate or extent of mononuclear cell proliferation. [GOC:add]
negative regulation of mononuclear cell proliferation definition: Any process that stops, prevents or reduces the frequency, rate or extent of mononuclear cell proliferation. [GOC:add]
positive regulation of mononuclear cell proliferation definition: Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation. [GOC:add]
Mononucleated Blood Cell definition: A mixture of cells possessing a single nucleus, including monocytes and lymphocytes; blood leukocytes from which granulocytes have been separated and removed.
monocyte aggregation definition: The adhesion of one monocyte to one or more other monocytes via adhesion molecules. [GOC:sl, PMID:12972508]