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Piperonyl Butoxide definition: An insecticide synergist, especially for pyrethroids and ROTENONE.
Piperonyl Butoxide definition: A synthetic derivative of benzodioxole and used as an insecticide synergist, Piperonyl Butoxide enhances the active properties of pyrethrin, pyrethroid, rotenone, and carbamate pesticide ingredients by inhibiting insect microsomal enzyme detoxification activity. It is toxic and suspected of causing anorexia, carcinogenesis, convulsions, and dermal irritation, as well as hepatic and renal damage. (NCI04)
immunology definition: branch of biomedical science concerned with the response of the organism to antigenic challenge, the recognition of self and foreign substances, and the biological, serological and physical chemical aspects of immune phenomena.
immunology definition: The study of the body's immune system.
Immunology definition: The study of the immune system and its reaction to pathogens, as well as its malfunctions (autoimmune diseases, allergies, rejection of organ transplants).
Nanocurie definition: A unit of radioactivity equal to one billionth of a curie or 37 becquerels, and corresponding to radioactivity of 37 atomic disintegrations per second.
nCi definition: A unit of radioactivity equal to one billionth of Curie or 37 Becquerels, and corresponding to a radioactivity of 37 atomic disintegrations per second.(NCI)
NCI Thesaurus definition: The NCI Thesaurus is a product of NCI's Enterprise Vocabulary Services. It arose from the need to have an institute wide common terminology to integrate the diverse data systems in use throughout NCI. Centralized coding of research related activities helped to meet various responsibilities of the Institute; however, supplementary data coding assigned independently by various components of the NCI made it difficult to find and combine related information across programs. By incorporating the terms in use by the various programs and mapping those to unique concepts, it was intended that the NCI Thesaurus would facilitate interoperability and data sharing within NCI. The NCI Thesaurus is a rigorous, cancer-centric, formal reference vocabulary with true is_a taxonomic structure, polyhierarchy, inferred partonomy, and other features that make it suitable for supporting complex query operations against appropriately coded data repositories.
Advisory Committee to the Director, NCI definition: The Committee advises and makes recommendations to the Director, NCI, for the oversight and integration of various planning and advisory groups serving the broad programmatic and institutional objectives of the Institute. The Committee serves as the official channel through which the findings and recommendations emerging from these groups are submitted to the NCI. The Committee may consider the reports of the various review groups as informational, advisory, or as recommendations, and shall provide the NCI with assistance in identifying opportunities to be pursued within the areas of cancer research that cut across the intramural and extramural programs.
Board of Scientific Advisors NCI definition: The NCI Board of Scientific Advisors, comprised of leading scientists and members of lay community, advises the Director and Deputy Director for Extramural Science, and the Director of each NCI Division on matters concerning scientific program policy, progress and future direction of extramural research programs. The advisory role of the Board is scientific and does not include deliberation on matters of public policy.
Board of Scientific Counselors, NCI definition: The NCI Board of Scientific Counselors comprised of leading scientists and members of the lay community, advises the Directors of the Intramural Division of the NCI and the Director and Deputy Director, NCI, on the matters concerning scientific program policy and the progress and future direction of research programs of each Division, including the evaluation of performance and productivity of each Division and staff scientists through periodic site visits to intramural laboratories, and evaluation and advice on the course of each Division's programs.
NCI-Designated Cancer Center definition: Centers coordinate multidisciplinary approaches to research questions, provide access to the most advanced research technologies and take rapid advantage of new research opportunities. (SPORES - Specialized Programs of Research Excellence are an example focused on specific disease). Additional examples include tobacco research, molecular and in-vivo imaging, communications, populations health and interventions directed against molecular targets.
NCI Administrative Concept definition: Conceptual entities required by NCI operations and systems. Includes administrative, financial, organizational and quasi-scientific concepts required for NCI operations and systems.
NCI Center for Cancer Research definition: Formed in Jan, 2001 by the merger of the Division of Clinical Sciences and the Division of Basic Sciences, the Center for Cancer Research is the largest component of the National Cancer Institute's Intramural Research Program.
Consortium or Network definition: Groups of scientists who link their expertise and resources in collaborative efforts to address important questions of shared interest.
NCI Initial Review Group definition: An Initial Review Group reviews grant and cooperative agreement applications for centers, research projects, and research training activities in the areas of cancer cause, diagnosis, treatment, and prevention; and contract proposals relating to all facets of cancer.
NCI Special Emphasis Panel definition: Advises the Director, National Cancer Institute (NCI), and the Director, Division of Extramural Activities, regarding research grant and cooperative agreement applications, contract proposals and concept review relating to basic and clinical sciences, and applied research and development programs of special relevance to the National Cancer Institute. Members and Chairs will be selected on an "as needed" basis in response to specific applications, proposals or proposed solicitations to be reviewed. Established by the Director, NCI, September 29, 1995. Currently authorized under 42 U.S. Code 284 (c)(3), Section 405(c)(3) of the Public Health Service Act, as amended. The Panel is governed by the provisions of Public Law 92-463, as amended (5 U.S.C. Appendix 2).
National Cancer Institute definition: NCI. The National Cancer Institute, part of the National Institutes of Health of the United States Department of Health and Human Services, is the Federal Government's principal agency for cancer research. NCI conducts, coordinates, and funds cancer research, training, health information dissemination, and other programs with respect to the cause, diagnosis, prevention, and treatment of cancer. Access the NCI Web site at http://cancer.gov.
National Cancer Institute (U.S.) definition: Component of the NATIONAL INSTITUTES OF HEALTH. Through basic and clinical biomedical research and training, it conducts and supports research with the objective of cancer prevention, early stage identification and elimination. This Institute was established in 1937.
National Cancer Institute definition: The Federal Government's principal agency for cancer research. NCI conducts, coordinates, and funds cancer research, training, health information dissemination, and other programs with respect to the cause, diagnosis, prevention, and treatment of cancer. Part of the National Institutes of Health of the United States Department of Health and Human Services.
NCI Annual Fact Book definition: An annual report, compiled and published by the staff of the financial management branch, detailing how the NCI distributed its budget among the various research programs and funding mechanisms. It also contains funding policies influencing grant awards, and comparisons with prior year allocations.
Common Scientific Outline NCI definition: The NCI Common Scientific Outline (CSO) is a classification system organized around seven broad areas of scientific interest in cancer research to lay the framework for better coordination among research organizations and funding agencies: cancer biology; cancer etiology; cancer prevention; cancer early detection, diagnosis, and prognosis; cancer treatment; cancer control, survivorship, and outcomes research; and scientific model systems. The NCI research portfolio is organized around the CSO categories.
Journal of the National Cancer Institute definition: The Journal of the National Cancer Institute publishes manuscripts that describe new findings of particular significance in any area relating to cancer, as well as associated news items, reviews, and opinion pieces. The Journal endeavors to appeal to a broad, multidisciplinary audience. Contents include: Peer-reviewed reports on major oncology studies from around the world; Editorials and commentary by leading experts on key articles and current controversies in cancer; The latest news from the oncology community, book reviews, and conference and position announcements. (from JNCI Information for Authors)
Office of the Director definition: Office of the NCI Director serves as the focal point for the National Cancer Program; develops a National Cancer Plan and monitors implementation of the plan; directs and coordinates the Institute's programs and activities; and develops and provides policy guidance and staff direction to the Institute's programs in areas such as program coordination, program planning, clinical care and administrative management.
Tissue Expediter definition: An NCI scientist whose role is to identify sources of human tissue specimens and help researchers locate the tissue and related data they need. (Bypass Budget)
NCI Unconventional Innovations Program definition: A program to spur development of daring technologic improvements in cancer treatment and detection in the 21st century. A five-year, $48 million program which seeks to stimulate development of radically new technologies in cancer care that can transform what is now impossible into the realm of the possible for detecting, diagnosing, and intervening in cancer at its earliest stages of development. The vision of the Unconventional Innovations Program is to couple detection and diagnostic technologies based on remote sensing to far less invasive treatments than those employed today which, though often effective, can be uncomfortable and painful. The ultimate goal of the program is to provide medical care for cancer patients that detects early cellular changes typical of cancer and includes treatments that target molecular alterations from occurring in an individual patient's cells. (from NIH news release 10/06/98)
Display_Name definition: Provides an alternative Preferred Name for use in some NCI systems.
NCI Thesaurus Association definition: An association is a non-hierarchical, named relationship between a source and target concept that does not affect classification and is not inherited by child concepts during classification. Associations are bidirectional and have a stated inverse. Unlike roles, associations do not have a domain or range.
NCI Thesaurus Concept definition: A concept is the basic unit of information contained in the Thesaurus. They describe sets of individuals in a given domain. A concept has a name, belongs to a Namespace and exists in relation to other concepts. The vertical relationships consist of "isa" statements that form a logical hierarchy (taxonomy or subsumption graph). In general, concepts above a given concept are referred to as superconcepts or parents and those below as subconcepts or children. In addition, there are horizontal named realationships between concepts called Roles, binary relations between concepts that provide a machine-interpretable definition of a concept and the means for discrimination of sibling concepts. A concept may also include Properties, named slots that allow attachment of external information to concepts.
NCI Concept Code definition: A concept unique identifier within the NCI Enterprise Vocabulary Service's NCI Thesaurus.
NCI Metathesaurus Code definition: A concept unique identifier within the NCI Enterprise Vocabulary Service's NCI Metathesaurus.
Concept History definition: The tracking of concept evolution over the lifetime of a vocabulary, includes concept creation, modification, merges, splits, and retirements.
NCI Thesaurus Property definition: This class encapsulates the name value properties of EVS Concept object. (NCI-SC)
NCI Thesaurus Property definition: A specific terminology property present in the NCI Thesaurus.
NCI Thesaurus Role definition: A specific non-hierarchical, named relationship between concepts present in the NCI Thesaurus.
NCI Concept Atom definition: In the NCI Thesaurus an atom consists of a term string, a term type, a term source, and an optional term code. They can be thought of as synonyms or alternative valid forms of a particular concept. This information resides in the property FULL_SYN.
NCI Thesaurus Qualifier definition: For each property or association you assign to a concept you also can specify an established qualifier type and value. For properties, the qualifier provides additional detail regarding the nature of a concept property (e.g., a property effective date, or an indicator reflecting that the property is Current). For associations, the qualifier provides additional detail regarding the nature of the concept association (for example, the degree of accuracy of the relationship, such as Usually).
NCI Enterprise Vocabulary Services definition: The NCI EVS is set of services and resources that address NCI's needs for controlled vocabulary. The EVS Project is a collaborative effort of the Center for Bioinformatics and the NCI Office of Communications. The NCI Thesaurus, which is a biomedical thesaurus created specifically to meet the needs of the NCI, is produced by the NCI EVS project. The NCI Thesaurus is provided under an open content license. The EVS Project also produces the NCI Metathesaurus, which is based on NLM's Unified Medical Language System Metathesaurus supplemented with additional cancer-centric vocabulary. In addition the EVS Project provides NCI with licenses for MedDRA, SNOMED, ICD-O-3, and other proprietary vocabularies.
NCI Namespace definition: The terminology entity that represents the NCI Thesaurus universe; the abstract container that holds all of the NCI Thesaurus terminology entities and concepts.
NCI Thesaurus Association Qualifier definition: For each association you assign to a concept you also can specify an established qualifier type and value. The qualifier provides additional detail regarding the nature of the concept association (for example, the degree of accuracy of the relationship, such as Usually).
NCI Thesaurus Entity definition: The terminology entities that represent the elements that form and define the NCI Thesaurus.
NCI Thesaurus Kind definition: The type of thing (disjoint set) represented in the NCI Thesaurus.
NCI Thesaurus Property Qualifier definition: For each property you assign to a concept you also can specify an established qualifier type and value. The qualifier provides additional detail regarding the nature of a concept property (e.g., a property effective date, or an indicator reflecting that the property is Current).
NCI_META_CUI definition: Contains a Concept Unique Identifier for those concepts that appear in NCI Metathesaurus but not in the NLM UMLS.
NCI Criterion definition: Criteria established for assigning high-frequency microsatellite instability (MSI-H) in cancers requiring that at least two of five markers (BAT25, BAT26, D2S123, D5S346, D17S250) score positive for MSI.
Chemical_Formula definition: Concise expression about the atoms that constitute a particular chemical compound.