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genetic polymorphism definition: simultaneous occurrence in the population of genomes showing allelic variations such as different phenotypes or restriction maps.
polymorphism definition: A common variation or mutation in DNA.
Polymorphism, Genetic definition: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.
Genetic Polymorphism definition: The regular and simultaneous occurrence of alternative nucleotide sequences at equivalent locations of the genetic material among individuals of a single interbreeding population that are not maintained by recurrent mutation. Polymorphisms may range in size from single nucleotide to large nucleotide sequence variation visible at the chromosomal level.
restriction fragment length polymorphism definition: individual differences in the fragmentation pattern of DNA after treatment with a restriction enzyme, due to fine details of genetic coding.
Polymorphism, Restriction Fragment Length definition: Variation occurring within a species in the presence or length of DNA fragment generated by a specific endonuclease at a specific site in the genome. Such variations are generated by mutations that create or abolish recognition sites for these enzymes or change the length of the fragment.
Restriction Fragment Length Polymorphism definition: Variation occurring within a species in the length of DNA fragments generated by a specific endonuclease. Such variations are generated by mutations that create or abolish recognition sites for these enzymes.
Restriction Fragment Length Polymorphism definition: Molecular, Restriction Fragment Length Polymorphism
Polymorphism, Single-Stranded Conformational definition: Variation in a population's DNA sequence that is detected by determining alterations in the conformation of denatured DNA fragments. Denatured DNA fragments are allowed to renature under conditions that prevent the formation of double-stranded DNA and allow secondary structure to form in single stranded fragments. These fragments are then run through polyacrylamide gels to detect variations in the secondary structure that is manifested as an alteration in migration through the gels.
single strand conformation polymorphism definition: method to detect mutations (sequence changes) in DNA by shifts in electrophoretic mobility of ssDNA (under nondenaturing conditions) due to conformational changes induced by the mutation.
Single-Stranded Conformational Polymorphism definition: A Single-Stranded Conformational Polymorphism consists of nucleotide sequence variation in the same region of DNA between individuals within a species, or between alleles in an individual, that cause partially denatured DNA fragments to take on different conformations as a result of their nucleotide sequences differences. These conformation differences can be detected through various gel-separation techniques.
biological polymorphism definition: existence of a species in several forms independent of the variations of sex; the property of crystallizing in two or more forms with distinct structure.
Polymorphism, Single Nucleotide definition: A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.
single nucleotide polymorphism definition: a single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.
Single Nucleotide Polymorphism definition: A variation of a single nucleotide at a specific location of the genome due to base substitution, present at an appreciable frequency between individuals of a single interbreeding population.
Polymorphism Analysis definition: Chemical or physical tests to determine DNA sequence variation
Copy Number Polymorphism definition: Variation in the number of copies of a particular sequence within the genetic material of an individual. Large-scale copy number polymorphisms are common and widely distributed in the human genome.
Short Tandem Repeat Polymorphism definition: Short Tandem Repeat Polymorphism consists of variation between individuals in the number of repeat units of Simple Tandem Repeats at a specific location in the genome. These are used extensively as markers in gene mapping and linkage analysis.
Molecular Microarrays, Mutation/Polymorphism definition: Microarrays designed to detect mutations or polymorphisms in a gene sequence. The packet samples on the microarray spots typically consist of immobilized DNA from a single gene; the sequence placed on any given spot of the microarray differs from that on other spots by only one or a few specific nucleotides. A sequence that is frequently used follows small single genetic variations that can occur within a human DNA sequence, known as single nucleotide polymorphisms (SNPs). Samples of labeled DNA from a person's normal tissue are hybridized to the array; the sample DNA will hybridize with greater frequency to SNPs particular to that person. If the sample SNP pattern is coincident to the known pattern for a given disease, the person has, or is at risk of having, the disease. Mutation/polymorphism molecular microarrays can be used to screen for inherited or acquired genetic susceptibility to a particular illness and/or other genetic characteristics (e.g., metabolism).
Molecular Arrays, Mutation/Polymorphism, Gene CYP2D6/CYP2C19 definition: Polymorphism detection microarrays designed to detect genetic variations in the genes 2D6 and 2C19 of the Cytochrome P450 pathway when used with a molecular assay analyzer. These microarrays can typically detect 29 known polymorphisms in the CYP2D6 gene, including gene duplication and deletion, resulting in the identification of 33 unique alleles; they can also permit the detection of two major polymorphisms in gene CYP2C19. These tests are used to characterize the patient phenotype, permitting a classification of the patient metabolic characteristics (e.g., poor, intermediate, extensive, or rapid metabolizers).
Polymorphism, Crystallization definition: Different crystal packing configurations which result in different properties such as SOLUBILITY which affects biological activity.
Polymorphism definition: The quality or state of being able to assume different forms.
polymorphism definition: Polymorphisme.
Polymorphie definition: [1] allgemein: Vielgestaltigkeit [2] Biologie: das normale Vorkommen prinzipiell unterschiedlich gestalteter Individuen innerhalb einer Art wie bspw. die Polymorphie der verschiedenen Kasten bei staatenbildenden Insekten (Arbeiterinnen, Soldaten, Königin etc.) [3] Biologie: das Auftreten einer Genvariation (eines Allels) in einer Population. [4] Chemie / Materialwissenschaft: die Eigenschaften einiger chemischer Verbindungen in zwei oder mehreren Modifikationen zu kristallisieren. [5] Informatik, Semantik von Programmiersprachen: Ein Bezeichner zeigt Polymorphie, wenn er Mehreres bedeuten kann. Erhält der Bezeichner mehrere Bedeutungen zugeschrieben, die sich in ihrem Typ unterscheiden, so spricht man auch von Overloading. Die gültige Bedeutung im Verwendungskontext legt dann der dortige Typ fest. Wird der Bezeichner im Zuge einer Vererbungskette redefiniert, so spricht man von Overriding. Die gültige Bedeutung im Verwendungskontext ergibt sich dann nach dem Prinzip „Die letzte Redefinition geht vor“. [6] Sprachwissenschaft: Vorhandensein von unterschiedlichen sprachlichen Ausdrucksformen für gleiche Bedeutungen oder grammatische Funktionen
polymorphisme definition: Propriété qu’ont certains corps d’affecter des formes très différentes sans changer de nature.