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Serum Amyloid A Protein definition: An ACUTE PHASE REACTION protein present in low concentrations in normal sera, but found at higher concentrations in sera of older persons and in patients with AMYLOIDOSIS. It is the circulating precusor of amyloid A protein, which is found deposited in AA type AMYLOID FIBRILS.
Erythroid Precursor Cells definition: The cells in the erythroid series derived from MYELOID PROGENITOR CELLS or from the bi-potential MEGAKARYOCYTE-ERYTHROID PROGENITOR CELLS which eventually give rise to mature RED BLOOD CELLS. The erythroid progenitor cells develop in two phases: erythroid burst-forming units (BFU-E) followed by erythroid colony-forming units (CFU-E); BFU-E differentiate into CFU-E on stimulation by ERYTHROPOIETIN, and then further differentiate into ERYTHROBLASTS when stimulated by other factors.
Hematopoietic Stem Cells definition: Progenitor cells from which all blood cells derive.
hematopoietic stem cell definition: progenitor cells from which all blood cells derive; a cell that can renew itself, can differentiate to a variety of specialized cells, can mobilize out of the bone marrow into circulating blood, and can undergo apoptosis.
Hematopoietic Stem Cell definition: Primitive blood cells derived from embryonic mesenchyme capable of differentiating into any of the blood cell line progenitor cells (erythroblasts, young granulocytic series cells, megakaryocytes, etc.)
Interleukin-4 definition: A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells.
interleukin 4 definition: lymphokine produced by antigen or mitogen activated T lymphocytes that enhances the ability of B lymphocytes to present antigen, primes B lymphocytes to proliferate in response to anti-Ig and lipopolysaccharide, and regulates the production of IgG and IgE by B lymphocytes; it also acts as a growth factor for T lymphocytes and as a maturation factor for mast cells.
interleukin-4 definition: Interleukin-4. A type of biological response modifier (a substance that can improve the body's natural response to disease) that enhances the immune system's ability to fight tumor cells. These substances are normally produced by the body. They are also made in the laboratory for use in treating cancer and other diseases.
interleukin-4 definition: (in-ter-LOO-kin) IL-4. A type of biological response modifier (a substance that can improve the body's natural response to infection and disease) that enhances the immune system's ability to fight tumor cells. These substances are normally produced by the body. They are also made in the laboratory for use in treating cancer and other diseases.
Interleukin-4 definition: Human interleukin-4 protein (153 aa, 17.5 kDa precursor) is encoded by the human interleukin-4 (IL4) gene. Two isoforms of this protein are expressed by activated T cells. This protein is a pleiotropic soluble cytokine that is a ligand for the interleukin 4 receptor. This receptor-ligand interaction induces expression of MHC II and Fc receptors on B-cells, causing proliferation and differentiation of these cells.
precursor mRNA definition: newly transcribed RNA fully complementary to the DNA sequence of structural genes; this component of the spliceosome and hnRNA is spliced, 5' capped, 3' polyadenylated, transported to the cytoplasm as mature mRNA, and translated.
Pro-Opiomelanocortin definition: A 30-kDa protein synthesized primarily in the ANTERIOR PITUITARY GLAND and the HYPOTHALAMUS. It is also found in the skin and other peripheral tissues. Depending on species and tissues, POMC is cleaved by PROHORMONE CONVERTASES yielding various active peptides including ACTH; BETA-LIPOTROPIN; ENDORPHINS; MELANOCYTE-STIMULATING HORMONES; and others (GAMMA-LPH; CORTICOTROPIN-LIKE INTERMEDIATE LOBE PEPTIDE; N-terminal peptide of POMC or NPP).
proopiomelanocortin definition: precursor polypeptide from which ACTH, MSH, and beta-lipotropin are produced by posttranslational cleavage.
Atrial Natriuretic Factor Precursors definition: Polypeptides of about 150 amino acids that serve as precursors to prohormone of ATRIAL NATRIURETIC FACTOR, a 126-amino acid polypeptide or ANP (1-126).
Secretogranin II definition: A type of chromogranin which was initially characterized in the ANTERIOR PITUITARY GLAND. It is found in several species including human, rat, mouse, and others. Secretogranin II is an acidic protein of 559 to 586 amino acid residues that can stimulate DOPAMINE release from neurons and release of pituitary GONADOTROPINS.
Secretogranin II definition: The protein is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. (LocusLink)
Amyloid beta-Protein Precursor definition: A precursor to the AMYLOID BETA-PROTEIN (beta/A4). Alterations in the expression of the amyloid beta-protein precursor (ABPP) gene, located on chromosome 21, plays a role in the development of the neuropathology common to both ALZHEIMER DISEASE and DOWN SYNDROME. ABPP is associated with the extensive extracellular matrix secreted by neuronal cells. Upon cleavage, this precursor produces three proteins of varying amino acid lengths: 695, 751, and 770. The beta/A4 (695 amino acids) or beta-amyloid protein is the principal component of the extracellular amyloid in senile plaques found in ALZHEIMER DISEASE; DOWN SYNDROME and, to a limited extent, in normal aging.
interleukin 15 definition: cytokine that stimulates the proliferation of T lymphocytes and shares biological activities with interleukin 2; it also can induce B lymphocyte proliferation and differentiation.
Interleukin-15 definition: Cytokine that stimulates the proliferation of T-LYMPHOCYTES and shares biological activities with IL-2. IL-15 also can induce proliferation and differentiation of B-LYMPHOCYTES.
Interleukin-15 definition: Interleukin-15, encoded by the IL15 gene, is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukin 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Three alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. (From LocusLink)
Adult Lymphoblastic Lymphoma definition: A lymphoblastic lymphoma occurring in adults.
Nucleoporin 98kD definition: Encoded by human NUP98 Gene (GLFG Nucleoporin Family), 937-amino acid Nucleoporin 98 kD (NUP98) is up regulated by interferon and generated through proteolytic cleavage of a 186 kD precursor yielding NUP98 and NUP96, both associated with the nuclear pore complex (NPC). NPC targeting of NUP96 and NUP98 is cleavage dependent, which may regulate assembly of the NPC, comprised of nearly fifty nucleoporins involved in signal-mediated nuclear import and export of protein and RNA. NUP98 likely functions as an import docking protein. The NUP98 C-terminal RNA-binding domain also contains NPC target sequences, a novel protein fold, and an autocatalytic protease. NUP98 docking/transport function is localized to N-terminal GLFG/FXFG repeats. mRNA nuclear export inhibition by Vesicular Stomatitis Virus M Protein targets NUP98. (from Swiss-Prot, OMIM, and NCI)
Interleukin-18 definition: A cytokine which resembles IL-1 structurally and IL-12 functionally. It enhances the cytotoxic activity of NK CELLS and CYTOTOXIC T-LYMPHOCYTES, and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity.
interleukin 18 definition: cytokine which resembles interleukin 1 structurally and interleukin 12 functionally; enhances cytotoxic activity of NK cells and CTLs; appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity.
Interleukin-18 definition: Cytokine which resembles IL-1 structurally and IL-12 functionally. It enhances the cytotoxic activity of NK cells and CTLs, and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity.
Interleukin-18 definition: IL18 is a cytokine that resembles IL1 structurally and IL12 functionally. It is expressed in Kupffer cells and in activated macrophages and augments the cytotoxic activity of NK cells and CTLs. By increasing expression of vascular cell adhesion molecule 1, as well as adherence of melanoma cells to capillary endothelia, IL18 may promote development of hepatic metastases of melanoma. (from OMIM 600953 and NCI)
Milk Fat Globule-EGF Factor 8 Protein definition: Milk fat globule-EGF factor 8 protein (387 aa, 43 kD) is a cell adhesion process protein that is encoded by the human MFGE8 gene and has a role in cell adhesion.
Angiotensinogen definition: A measurement of the angiotensinogen hormone in a biological specimen.
Angiotensinogen Measurement definition: The determination of the amount of angiotensinogen hormone present in a sample.
Adult Acute Lymphoblastic Leukemia definition: An acute lymphoblastic leukemia occurring during adulthood.
Interleukin-19 definition: Interleukin-19, encoded by the IL19 gene, is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. (From LocusLink)
amyloid precursor protein biosynthetic process definition: The chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer's disease. [GOC:go_curators]
Precursor definition: A substance from which another substance is formed.
precursor definition: Précurseur, prédécesseur.
forerunner definition: Précurseur, prédécesseur.
Vorläufer definition: [1] Wegbereiter [2] Sport: jemand, der einen Bewerb vor den gewerteten Sportlern bestreitet [3] Färberwesen: Anfangs- oder Endstreifen eines Gewebebandes
Präkursor definition: [1] Biochemie: Biomolekül, das erst durch Modifikation in ein biologisch aktives Molekül überführt wird [2] Drogenherstellung: Stoff, aus dem Drogen hergestellt werden können
bandeirante definition: Pionnier.
pioneiro definition: Pionnier.
precursor definition: Pionnier.
pionnier definition: Travailleur dont on se sert dans une armée pour aplanir les chemins, pour creuser des lignes et des tranchées, et pour remuer la terre dans différentes occasions.
pionnier definition: En parlant de l’Amérique du Nord, premiers colons qui s’établissent sur des terres incultes et désertes pour les défricher.
pionnier definition: Homme qui s’attache à une entreprise nouvelle, qui fait gagner un terrain nouveau à une influence.
pionnier definition: Au sein de certains mouvements scout, désigne un scout arrivant en fin de parcours en tant qu'animé (généralement entre 16 et 18 ans). Les pionniers composent le poste dans une unité.
pionnier definition: Membre des jeunesses communistes.
précurseur definition: Celui qui vient avant quelqu’un pour en annoncer la venue. Il se dit principalement de saint Jean-Baptiste, que l’on appelle.
précurseur definition: Homme qui prépare la voie, qui précède et annonce un grand homme, un mouvement, une découverte.
précurseur definition: Certaines choses qui pour l’ordinaire en précèdent d’autres.
précurseur definition: Molécule qui par une réaction biochimique va donner naissance à une autre molécule.
prédécesseur definition: Celui qui a précédé quelqu’un dans un emploi, dans une charge, dans une dignité, etc.
prédécesseur definition: , Tous ceux qui ont vécu avant nous dans le même pays ; et, en ce sens, il ne s’emploie qu’au pluriel.