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Heat Shock 70kD Protein Binding Protein definition: Encoded by human candidate tumor suppressor gene ST13 Gene, cytoplasmic 369-aa 41-kDa homotetrameric Heat Shock 70kD Protein Binding Protein is an adaptor protein containing 3 TPR repeats involved in assembly of glucocorticoid receptor, which requires the assistance of multiple chaperones. Dependent on HSC70 ATPase activation by HSP40, ST13 oligomer binds HSC70 ATPase domains and stabilizes the HSC70 ADP state that has high affinity for substrate protein. ST13 mediates HSP70 and HSP90 association and may interact with DNAJ homologs. Gene expression is downregulated in colorectal carcinoma. (NCI)
Epididymal Secretory Protein E4 definition: Expressed in several tissues, including male reproductive system, respiratory tract, and nasopharynx as 5 alternatively spliced transcripts, human WFDC2 Gene (WFDC Family) encodes 5 secreted isoforms of Epididymal Secretory Protein E4 that contain one or two WFDC domains. The WFDC domain contains eight cysteines forming four disulfide bonds at the protein core and often functions in protease inhibition. WFDC2 may be involved in sperm maturation. (NCI)
RNA Binding Motif Protein 5 definition: Widely expressed by human RBM5 Gene, 815-aa 92-kDa RNA Binding Motif Protein 5 contains 2 RRM domains, a G-patch domain, and a RANBP2-type zinc finger and specifically binds to RNA. (NCI)
Protein Translation Factor SUI1 Homolog definition: Encoded by human SUI1 Gene (SUI1 Family), 113-aa 12.7-kDa Protein Translation Factor SUI1 Homolog is a putative negative growth regulator likely involved in translation. (NCI)
Transcription Factor-Like Nuclear Regulator definition: Encoded by widely expressed human BDP1 Gene, 2254-aa 253-kD highly hydrophilic Transcription Factor-Like Nuclear Regulator contains several potential phosphorylation sites, two bipartite NLS, a DNA-ligase A1 ATP-dependent binding site, a MYB-like domain, and 9 copies of a 55-amino acid motif. Similar to yeast TFC5 and required for RNA polymerase III transcription, BDP1 binds promoter regions, suggesting that it is part of the initiation complex. (NCI)
Nuclear Receptor Binding Protein definition: Expressed by human NRBP Gene, ubiquitous 535-aa 60-kDa Nuclear Receptor Binding Protein is a putative adaptor protein containing 2 putative nuclear receptor-binding motifs, a putative binding domain for SH2 domain-containing proteins, a kinase-like domain, a bipartite nuclear localization signal, and 3 PEST sequences. Mouse and rat NRBP homologs exhibit 91% and 89% identity with NRBP. (NCI)
Putative GR6 Protein definition: Normally expressed in early fetal development by human GR6 Gene, the function of 149-aa 16-kDa Putative GR6 Protein is unknown. (NCI)
Exostosin-Like 3 Protein definition: Ubiquitously expressed by human EXTL3 Gene (EXT Family), 919-aa 105-kDa Exostosin-Like 3 is a type II membrane protein glycosyltransferase of the endoplasmic reticulum likely involved in chain initiation and elongation during heparan sulfate/heparin biosynthesis. EXTL3 contains a highly conserved C-terminal region, common to other EXT proteins. (NCI)
RET Finger Protein 2 definition: Encoded by human RFP2 Gene (TRIM Family), 407-aa 47-kDa RET Finger Protein 2, of unknown function, is localized to cytoplasmic bodies near the nucleus and contains a TRIM motif: 3 zinc-binding domains, a RING, type 1 and type 2 B-boxes, and a coiled-coil region. RFP2 may act as a tumor suppressor and may be involved in 13q14 deletion B-CLL. (NCI)
NUP214 Gene definition: This gene plays a critical role in nuclear transport and docking regulation. Alterations in the gene have been associated with several cancers and leukemias.
Putative Transmembrane Protein NMA definition: Expressed in melanocytes, kidney, placenta, spleen, liver, prostate, and gut by human NMA Gene, 260-aa 29-kDa (precursor) Putative Transmembrane Protein NMA contains a signal sequence and a transmembrane domain. (NCI)
TUSC3 Gene definition: This gene may play a role in the negative regulation of cell growth.
RNA Recognition Motif definition: RNA Binding Domains, such as the RRM, RGG box, and KH domain, mediate the interaction of RNAs with RNA-binding proteins. RRMs of about 90 amino acids consist of a four-stranded beta sheet adjacent to two alpha helixes. Within RRMs, conserved RNP-1 and RNP-2 motifs on the central beta sheets lie side by side; their side chains contact RNA. Found in hnRNP proteins, the RGG box is an RNA-binding motif containing five Arg-Gly-Gly repeats with intervening aromatic residues. The KH domain is found in several RNA-binding proteins in multiple repeats interspersed with RGG boxes. (NCI)
RNA Recognition Motif definition: The RNA Recognition Motif is likely diagnostic of an RNA binding protein. In addition to being found in some single-stranded DNA binding proteins, one or more RRMs of about 90 amino acids are found in various RNA binding proteins: hnRNPs, regulators of alternative splicing, and snRNP protein components. There are two highly conserved RRM regions: RNP-1 or RNP-CS, an octapeptide motif, and RNP-2, a six-residue hydrophobic segment. RRM consists of a four-stranded beta sheet adjacent to two alpha helixes. RNP-1 and RNP-2 on the central beta sheets lie side by side; their side chains contact RNA. (NCI)
CHMP2A Gene definition: This gene plays a role in membrane transport regulation.
EIF1 wt Allele definition: Human EIF1 wild-type allele is located in the vicinity of 17q21.2 and is approximately 3 kb in length. This allele, which encodes eukaryotic translation initiation factor 1 protein, plays a role that is essential for the initiation of messenger RNA translation.
Midline-1 definition: Midline-1 (667 aa, ~75 kDa) is encoded by the human MID1 gene. This protein is involved in microtubule formation.