dict.md logo
Choose languages of interest
SELECT >>
English
Advertisement:
Definition
 
enEnglish
Carcinoma with t(15;19)(q13;p13.1) Translocation definition: A rare, aggressive carcinoma of unknown histogenesis, characterized by the presence of undifferentiated malignant cells affecting the mediastinum and other midline organs. It is associated with the t(15;19)(q13;p13.1) translocation that generates the BRD4-NUT fusion oncogene. -- 2005
Reagents, Molecular Assay, Chromosome Anomaly, Translocation, t(11;14)(q13;q32) definition: Molecular assay reagents intended for use in identifying exchanges (i.e., translocations)between chromosome 11 band q13 and chromosome 14 band q32, usually involving genes BCL-1 and IGH, respectively. This translocation is present mainly in patients with B-cell chronic lymphocytic leukemia (B-CLL), but it is also associated with other types of leukemia and multiple myeloma. Its detection may be used as a tumor marker.
Reagents, Molecular Assay, Chromosome Anomaly, Translocation, t(12;22)(q13;q12) definition: Molecular assay reagents intended for use in identifying exchanges (i.e., translocations) between chromosome 12 band q13 and chromosome 22 band q12, usually involving genes ATF1 and EWSR1, respectively. This translocation is present in some cases of malignant melanoma and soft-tissue clear-cell sarcoma. Its detection may be used as a tumor marker.