dict.md logo
Choose languages of interest
SELECT >>
English
French
German
Italian
Advertisement:
Definition
 
enEnglish
Recombination, Genetic definition: Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.
genetic recombination definition: natural process of exchange of DNA between two homologous chromosomes during mitosis; do not confuse with RECOMBINANT DNA, which applies to artificial DNA constructs.
DNA recombination definition: Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
Recombination definition: A natural process of exchange of DNA between chromosomes during mitosis; not recombinant DNA, which applies to artificial DNA constructs. The production of new arrangements of genes by various mechanisms such as assortment and segregation, crossing over, gene conversion, transformation, conjugation, transduction, F-duction, or mixed infection of viruses.
Genes, RAG-1 definition: Genes involved in activating the enzyme VDJ recombinase. RAG-1 is located on chromosome 11 in humans (chromosome 2 in mice) and is expressed exclusively in maturing lymphocytes.
V(D)J Recombination-Activating Protein 1 definition: V(D)J recombination-activating protein 1 (1043 aa, ~119 kDa) is encoded by the human RAG1 gene. This protein is involved in the regulation of V-D-J recombination.
RAG1 Gene definition: This gene is involved in immunoglobulin diversity.
Immunoglobulin J Recombination Signal Sequence-Binding Protein definition: A ubiquitously expressed sequence-specific transcriptional repressor that is normally the target of signaling by NOTCH PROTEINS.
Homologous Recombination definition: Exchange of like DNA sequences on homologous chromosomes by recombination.
reciprocal meiotic recombination definition: The cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity. [PMID:2087779]
Meiotic Recombination definition: Extensive Meiotic Recombination occurs during meiosis when the cell performs a round of DNA replication (meiS) followed by homolog synapsis and recombination that involves breakage of chromosomes or DNA molecules and rejoining of fragments in new combinations.
meiotic recombination nodule assembly definition: During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes. [GOC:jl, PMID:9334324]
mitotic recombination definition: The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous region of DNA that occurs during mitotic cell cycles. [GOC:elh]
Mitotic Recombination definition: Mitotic Recombination, crossing over, can occur between homologous chromosomes during mitosis, but is very rare because the chromosomes do not normally pair. Chromosomes or DNA molecules are broken and the fragments are rejoined in new combinations of previously linked genes.
recombination within rDNA repeats definition: Genetic recombination within the DNA of the genes coding for ribosomal RNA. [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
recombinational repair definition: The repair of damaged DNA that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA. [GOC:elh]
Recombination Repair definition: Homologous recombination can operate at both double-strand breaks and free ends. The homologous chromosome serves as a template for DNA repair during recombination.
regulation of mitotic recombination definition: Any process that modulates the frequency, rate or extent of DNA recombination during mitosis. [GOC:go_curators]
negative regulation of mitotic recombination definition: Any process that inhibits or decreases the rate of DNA recombination during mitosis. [GOC:go_curators, GOC:hjd]
positive regulation of mitotic recombination definition: Any process that activates or increases the frequency, rate or extent of DNA recombination during mitosis. [GOC:go_curators]
plasmid recombination definition: A process of DNA recombination occurring within a plasmid or between plasmids and other plasmids or DNA molecules. [GOC:mlg]
regulation of DNA recombination definition: Any process that modulates the frequency, rate or extent of DNA recombination, a process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
negative regulation of DNA recombination definition: Any process that stops, prevents or reduces the frequency, rate or extent of DNA recombination. [GOC:go_curators]
positive regulation of DNA recombination definition: Any process that activates or increases the frequency, rate or extent of DNA recombination. [GOC:go_curators]
RNA-mediated DNA recombination definition: The reverse transcription of an RNA molecule followed by recombination between the resultant cDNA and its homologous chromosomal allele. [GOC:jl, PMID:8380627]
somatic cell DNA recombination definition: Recombination occurring within or between DNA molecules in somatic cells. [GOC:ma]
activation of recombination (HML) definition: The activation of recombination at a mating type locus, such that it is used in preference to the other donor locus for mating type switching; exemplified by the HML locus and surrounding sequences on Chromosome III in Saccharomyces cerevisiae. [GOC:mah, PMID:9928492]
inactivation of recombination (HML) definition: The inactivation of recombination at sequences around a mating type donor locus, with the consequence that the other donor is the only one available for mating type switching; exemplified by the HML locus and surrounding sequences on Chromosome III in Saccharomyces cerevisiae. [GOC:mah, PMID:9928492]
recombination nodule definition: An electron dense structure that is associated with meiotic chromosomes. [GOC:elh]
early recombination nodule definition: An electron dense structure that is associated with meiotic chromosomes in leptotene or zygotene during meiosis I. [GOC:elh]
late recombination nodule definition: An electron dense structure that is associated with meiotic chromosomes in pachytene during meiosis I. [GOC:elh]
Recombination, Interspecies definition: Recombination occurring between genes from different species.
negative regulation of DNA recombination at telomere definition: Any process that stops, prevents or reduces the frequency, rate or extent of genetic recombination within the telomere. [GOC:jic, PMID:9635193]
RAG2 Gene definition: This gene plays a role in immunoglobulin diversity.
Immunoglobulin Switch Recombination definition: B-lymphocytes can selectively switch to express different immunoglobulin (Ig) isotypes during the course of an immune response. Selective expression of an Ig isotype is regulated by a sequence-specific rearrangement process that replaces the first active set of Ig heavy-chain (IgH) constant-region exons with one of several other downstream constant-region (CH) genes.
Radiation-Induced Recombination definition: Radiation-Induced Recombination involves double-stranded breaks in DNA caused by ionizing radiation, e.g., X-rays or gamma rays, that induce cellular repair functions and rejoining of the fragments in new combinations.
Recombination Fraction definition: The percentage of individuals in a population with a non-parental genotype.
Telomere Recombination definition: Recombination can lead to the net elongation of telomeres. The sequence at the ends of chromosomes is highly repetitive and is identical on all telomeres in a given species. The 3-prime end of one chromosome can invade a second chromosome and use the sequence of the second chromosome as a template for telomere elongation by DNA polymerase. The lagging strand can then be filled in by conventional replication mechanisms.
Tissue Recombination definition: A technique used in developmental biology to investigate the effects of one tissue upon another in induction of differentiation and tissue and organ formation. Basically, a piece of tissue is transplanted from its normal location to a new location. This helps to distinguish between intrinsic and extrinsic influences in organ formation.
meiotic recombination checkpoint definition: A checkpoint during late prophase I (pachytene) which prevents segregation of homologous chromosomes until recombination is completed and ensures proper distribution of the genetic material to the gametes. [PMID:14718568]
immunoglobulin V(D)J recombination definition: The process by which immunoglobulin heavy chain V, D, and J gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). For immunoglobulin light chains the same process is used to join V and J gene segments directly. [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
negative regulation of reciprocal meiotic recombination definition: Any process that decreases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate. [GOC:ai, GOC:dph, GOC:tb]
RC-1 DNA recombination complex definition: A protein complex that contains DNA ligase III, DNA polymerase epsilon, a 5'-3' exonuclease, and the SMC1 and SMC2 proteins, and is involved in recombinational repair of deletions and gaps in DNA. [PMID:8392064, PMID:8670910]
regulation of reciprocal meiotic recombination definition: Any process that modulates the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate. [GOC:dph, GOC:tb]
recombination hotspot binding definition: Interacting selectively with a region in a genome which promotes recombination. [GOC:dph, GOC:tb]
activation of reciprocal meiotic recombination definition: Any process that starts the inactive process of reciprocal meiotic recombination. Reciprocal meiotic recombination is the cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate. [GOC:dph, GOC:tb]
 
 
frFrench
recombinaison definition: Action de recombiner, résultat de cette action.