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Calmodulin definition: A heat-stable, low-molecular-weight activator protein found mainly in the brain and heart. The binding of calcium ions to this protein allows this protein to bind to cyclic nucleotide phosphodiesterases and to adenyl cyclase with subsequent activation. Thereby this protein modulates cyclic AMP and cyclic GMP levels.
calmodulin definition: intracellular protein that mediates the calcium dependence of many enzymes and cell functions.
Cyclic AMP Receptor Protein definition: A transcriptional regulator in prokaryotes which, when activated by binding cyclic AMP, acts at several promoters. Cyclic AMP receptor protein was originally identified as a catabolite gene activator protein. It was subsequently shown to regulate several functions unrelated to catabolism, and to be both a negative and a positive regulator of transcription. Cell surface cyclic AMP receptors are not included (CYCLIC AMP RECEPTORS), nor are the eukaryotic cytoplasmic cyclic AMP receptor proteins, which are the regulatory subunits of CYCLIC AMP-DEPENDENT PROTEIN KINASES.
Genes, Regulator definition: Genes which regulate or circumscribe the activity of other genes; specifically, genes which code for PROTEINS or RNAs which have GENE EXPRESSION REGULATION functions.
regulatory gene definition: structural genes that code for proteins which bind to DNA and regulate genetic events; compare with GENETIC REGULATORY ELEMENT and STRUCTURAL GENE.
Regulatory Gene definition: Regulatory Genes encode products that regulate or circumscribe the activity of diverse cellular functions.
Proto-Oncogene Proteins c-crk definition: Signal transducing adaptor proteins that contain SRC HOMOLOGY DOMAINS and play a role in CYTOSKELETON reorganization. c-crk protein is closely related to ONCOGENE PROTEIN V-CRK and includes several alternatively spliced isoforms.
TATA-Binding Protein-Associated Phosphoprotein definition: Encoded by human DR1 Gene, TATA-Binding Protein-Associated Phosphoprotein represses both basal and activated levels of transcription. DR1 phosphorylation affects its interaction with TBP. The DR1 protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region and represses transcription with DRAP1 by inhibiting pre-initiation complex formation through interaction with TFIID and DNA. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. (NCI)
REGULATOR, VACUUM definition: A vacuum-powered body fluid suction apparatus is a device used to aspirate, remove, or sample body fluids. The device is powered by an external source of vacuum. This generic type of device includes vacuum regulators, vacuum collection bottles, suction catheters and tips, connecting flexible aspirating tubes, rigid suction tips, specimen traps, noninvasive tubing, and suction regulators (with gauge).
BCL2-Associated X Protein definition: The BAX gene produces at least four proteins by alternate splicing: membrane-bound alpha and cytoplasmic beta, gamma, and delta; all bind and antagonize BCL2, which represses programmed cell death. Pro-apoptotic BAX acts as a partner of BCL2, shows extensive homology with BCL2, and forms homodimers and heterodimers with BCL2. Pro-apoptotic BAX and BAK proteins accelerate opening of the mitochondrial porin channel, VDAC. BAX appears to interact, and cooperate, with the constitutive pro-apoptotic ANT mitochondrial protein within the pore complex to increase mitochondrial permeability, allowing cytochrome C passage and triggering cell death. Expression of BAX is a significant prognostic factor in patients with gastric lymphoma. Its prognostic value increases significantly when studied in BCL2-negative patients. (from OMIM 600040 and NCI)
bcl-2-Associated X Protein definition: A member of the Bcl-2 protein family and homologous partner of C-BCL-2 PROTO-ONCOGENE PROTEIN. It regulates the release of CYTOCHROME C and APOPTOSIS INDUCING FACTOR from the MITOCHONDRIA. Several isoforms of BCL2-associated X protein occur due to ALTERNATIVE SPLICING of the mRNA for this protein.
oncoprotein p21 definition: cyclin dependent kinase inhibitor which prevents cells from progressing into S phase of the cell cycle; also, causes a G1 block to cell cycle progression in response to antimitogenic stimuli or other environmental cues.
Cyclin-Dependent Kinase Inhibitor 1A definition: May mediate p53 inhibition of cell proliferation in response to DNA damage. CIP1 appears to be a tight-binding inhibitor of CDKs. CDKN1A expression is tightly regulated by p53 and IFN-Beta. The CIP1 N-terminus is similar to KIP1. CIP1 is truncated by CASP3 in apoptosis. (from SWISS-PROT P38936, OMIM 116899, and NCI)
Cyclin-Dependent Kinase Inhibitor p21 definition: A cyclin-dependent kinase inhibitor that mediates TUMOR SUPPRESSOR PROTEIN P53-dependent CELL CYCLE arrest. p21 interacts with a range of CYCLIN-DEPENDENT KINASES and associates with PROLIFERATING CELL NUCLEAR ANTIGEN and CASPASE 3.
BCL2-Antagonist/Killer 1 definition: A BCL2 related protein that induces apoptosis. May cause the mitochondrial voltage-dependent anion channel to open and release cytochrome c into the cytoplasm resulting in caspase activation. (from RefSeq Summary)
bcl-2 Homologous Antagonist-Killer Protein definition: A multi-domain mitochondrial membrane protein and member of the bcl-2 Protein family. Bak protein interacts with TUMOR SUPPRESSOR PROTEIN P53 and promotes APOPTOSIS.
REGULATOR, TEMPERATURE definition: General purpose laboratory equipment labeled or promoted for a specific medical use is a device that is intended to prepare or examine specimens from the human body and that is labeled or promoted for a specific medical use.
SPT5 Protein definition: Believed to be part of a transcriptional-repression protein complex involved in modulating chromatin structure. The SPT5 amino terminus is highly acidic, while the C-terminus contains seven Mitogen-Activated Protein (MAP) Kinase consensus sequences. (OMIM 602102 and NCI)
apoptosis regulator activity definition: OBSOLETE. The function held by products which directly regulate any step in the process of apoptosis. [GOC:jl]
chaperone regulator activity definition: OBSOLETE. Modulates the activity of a molecular chaperone. [GOC:mah]
cytoskeletal regulator activity definition: OBSOLETE (was not defined before being made obsolete). [GOC:mah]
acetylcholine receptor regulator activity definition: Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is changed. [GOC:mah]
channel regulator activity definition: Modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. [GOC:mah]
calcium channel regulator activity definition: Modulates the activity of a calcium channel. [GOC:mah]
chloride channel regulator activity definition: Modulates the activity of a chloride channel. [GOC:mah]
SPT6 Protein definition: A nuclear protein that may regulate transcription through control of chromatin structure. SPT6 contains a highly acidic region, a degenerate SH2 domain, and a leucine zipper. (from OMIM 601333 and NCI)
caspase regulator activity definition: Modulates the activity of a caspase, any of a group of cysteine proteases involved in apoptosis. [GOC:jl, Wikipedia:Caspase]
1-phosphatidylinositol-3-kinase regulator activity definition: Modulates the activity of the enzyme 1-phosphatidylinositol-3-kinase activity. [GOC:ai]
cell cycle regulator definition: OBSOLETE (was not defined before being made obsolete). [GOC:krc]
Apoptosis Regulator definition: Encoded by Apoptosis Regulation Genes, Apoptosis Regulator proteins either promote or impede the initiation, progress, or rate of apoptosis.
BCL2-Related 2 Protein definition: This protein is a member of the BCL-2 protein family. Expression of this protein in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. (from RefSeq Summary)
AraC Transcription Factor definition: A transcription factor found in BACTERIA that positively and negatively regulates the expression of proteins required for the uptake and catabolism of L-ARABINOSE.
regulation of nitric-oxide synthase activity definition: Any process that modulates the activity of the enzyme nitric-oxide synthase. [GOC:ai]
regulation of ligase activity definition: Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. [EC:6.-.-.-, GOC:ai]
regulation of hydrolase activity definition: Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. [EC:3.-.-.-, GOC:ai]
regulation of transferase activity definition: Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. [EC:2.-.-.-, GOC:ai]
regulation of oxidoreductase activity definition: Any process that modulates the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. [EC:1.-.-.-, GOC:ai]
regulation of lyase activity definition: Any process that modulates the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. [EC:4.-.-.-, GOC:ai]
Regulator definition: Something that controls the rate or manner in which a process progresses or a product is formed.
regulation of telomerase activity definition: Any process that modulates the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Telomerases catalyze extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence. [EC:2.-.-.-, GOC:ai]
acetylglutamate kinase regulator activity definition: Modulates the enzyme activity of acetylglutamate kinase. [PMID:16377628]
cyclase regulator activity definition: Modulates the activity of an enzyme that catalyzes a ring closure reaction. [GOC:dph, GOC:tb]
adenylate cyclase regulator activity definition: Modulates the activity of the enzyme that catalyzes the reaction: ATP = 3',5'-cyclic AMP + diphosphate. [GOC:dph, GOC:tb]
Säureregulator definition: [1] Lebensmittelchemie: Lebensmittelzusatzstoff, der den Säuregehalt des Lebensmittels konstant hält
kompas definition: Boussole.
regulator definition: Régulateur.