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fibroblast growth factor definition: family of structurally related polypeptides which have important roles in cell development, differentiation, and motility, as well as angiogenesis, neurogenesis, wound healing, and tumor growth.
Fibroblast Growth Factors definition: A family of small polypeptide growth factors that share several common features including a strong affinity for HEPARIN, and a central barrel-shaped core region of 140 amino acids that is highly homologous between family members. Although originally studied as proteins that stimulate the growth of fibroblasts this distinction is no longer a requirement for membership in the fibroblast growth factor family.
Fibroblast Growth Factor definition: Peptide isolated from the pituitary gland and from the brain. It is a potent mitogen which stimulates growth of a variety of mesodermal cells including chondrocytes, granulosa, and endothelial cells. The peptide may be active in wound healing and animal limb regeneration.
Genes, Regulator definition: Genes which regulate or circumscribe the activity of other genes; specifically, genes which code for PROTEINS or RNAs which have GENE EXPRESSION REGULATION functions.
regulatory gene definition: structural genes that code for proteins which bind to DNA and regulate genetic events; compare with GENETIC REGULATORY ELEMENT and STRUCTURAL GENE.
Regulatory Gene definition: Regulatory Genes encode products that regulate or circumscribe the activity of diverse cellular functions.
Regulatory Sequences, Nucleic Acid definition: Nucleic acid sequences involved in regulating the expression of genes.
genetic regulatory element definition: binding sites on DNA for proteins that control genetic events; compare with STRUCTURAL GENE and REGULATORY GENE.
Regulatory Element definition: Any DNA sequence involved in the regulation of genetic processes such as transcription and replication.
Interferon Regulatory Factor-1 definition: An interferon regulatory factor that binds upstream TRANSCRIPTIONAL REGULATORY ELEMENTS in the GENES for INTERFERON-ALPHA and INTERFERON-BETA. It functions as a transcriptional activator for the INTERFERON TYPE I genes.
Interferon Regulatory Factor-2 definition: An interferon regulatory factor that represses transcription of TYPE I INTERFERONS and activates transcription of HISTONE H4.
COUP Transcription Factor 2 definition: COUP transcription factor 2 (414 aa, ~46 kDa) is encoded by the human NR2F2 gene. This protein is involved in the mediation of transcription.
COUP Transcription Factor II definition: A COUP transcription factor that negatively regulates GENETIC TRANSCRIPTION and competes with other hormone receptors for the common response element AGGTCA. It can also stimulate transcription of genes involved in the metabolism of GLUCOSE and CHOLESTEROL.
Heparin-Binding Neurotrophic Factor definition: Heparin-Binding Neurotrophic Factors are a family of polypeptide growth factors produced by peripheral target tissues, as well as the nervous system, that block apoptosis and promote neuronal growth, regeneration, survival, and differentiation. Many growth factors appear to temporarily and non-covalently interact with the glycosaminoglycan heparin, which may affect growth factor activity.
Pleiotrophin definition: Heparin-binding neurite outgrowth-promoting factor is a member of a highly conserved human gene family of proteins. It exhibits neurite outgrowth-promoting activity and may play a role in nervous tissue development and/or maintenance. It was renamed pleiotrophin (PTN) to reflect its diverse activities. Expression of this factor is developmentally regulated, increasing in the brain during embryogenesis and reaching its maximum expression at the time of birth. The gene codes for a 168-residue protein that is a precursor for a previously described brain-derived heparin-binding protein of 136 amino acids. (from OMIM)
Pleiotrophin definition: A secreted growth factor that is mitogenic for endothelial, epithelial, and fibroblast cells but can also induce neurite outgrowth. It functions as a growth factor during neonatal brain development, for primate trophoblast formation, and during tumor invasion, angiogenesis, and metastasis.
GTP-Binding Proteins definition: Regulatory proteins that act as molecular switches. They control a wide range of biological processes including: receptor signaling, intracellular signal transduction pathways, and protein synthesis. Their activity is regulated by factors that control their ability to bind to and hydrolyze GTP to GDP. EC 3.6.1.-.
G protein definition: family of small membrane-bound proteins which, in the presence of GTP/GDP, transduce signals from receptor to effector molecules across the membrane; do not use for other guanine nucleotide binding proteins.
G Protein definition: G Proteins are a family of small membrane-bound regulatory proteins that act as GTP/GDP-binding molecular switches controlling a wide range of biological processes including: transmembrane receptor signaling, intracellular signal transduction pathways, and protein synthesis. Their activity is regulated by factors that control their ability to bind to and hydrolyze GTP to GDP.
appetite regulatory center definition: group of cells in the hypothalamus that when stimulated cause or suppress the sensation of hunger; the lateral hypothalamus contains the group of cells that when stimulated cause hunger sensation; the ventromedial hypothalamus contains the group of cells that when stimulated suppress the desire for food.
Myogenic Regulatory Factors definition: A family of muscle-specific transcription factors which bind to DNA in control regions and thus regulate myogenesis. All members of this family contain a conserved helix-loop-helix motif which is homologous to the myc family proteins. These factors are only found in skeletal muscle. Members include the myoD protein (MYOD PROTEIN); MYOGENIN; myf-5, and myf-6 (also called MRF4 or herculin).
Cell Cycle Proteins definition: Proteins that control the CELL DIVISION CYCLE. This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS.
cell cycle protein definition: family of proteins that control the cell divisions cycle; includes a wide variety of classes, including cyclin dependent kinases, mitogen activated kinases, cyclins, and phosphoprotein phosphatases as well as their putative substrates such as chromatin associated proteins, cytoskeletal proteins, and transcription factors.
Cell Cycle Protein definition: Proteins involved in the process of cell division. Numerous proteins of different functionality and type are involved in this process.
Antigens, CD98 definition: A heterodimeric protein that is a cell surface antigen associated with lymphocyte activation. The initial characterization of this protein revealed one identifiable heavy chain (ANTIGENS, CD98 HEAVY CHAIN) and an indeterminate smaller light chain. It is now known that a variety of light chain subunits (ANTIGENS, CD98 LIGHT CHAINS) can dimerize with the heavy chain. Depending upon its light chain composition a diverse array of functions can be found for this protein. Functions include: type L amino acid transport, type y+L amino acid transport and regulation of cellular fusion.
Integrin alpha3 definition: An integrin alpha subunit that occurs as alternatively spliced isoforms. The isoforms are differentially expressed in specific cell types and at specific developmental stages. Integrin alpha3 combines with INTEGRIN BETA1 to form INTEGRIN ALPHA3BETA1 which is a heterodimer found primarily in epithelial cells.
Interferon Regulatory Factor 4 definition: Interferon regulatory factor 4 is a transcriptional activator that binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter and to the immunoglobulin lambda light chain enhancer, together with PU.1. IRF4 probably plays a role in the ISRE-targeted signal transduction mechanisms of lymphoid cells. Two isoforms are produced by alternative splicing. (from OMIM 601900 and NCI)
Interferon-Stimulated Gene Factor 3, gamma Subunit definition: An interferon regulatory factor that recruits STAT1 PROTEIN and STAT2 PROTEIN heterodimers to interferon-stimulated response elements and functions as an immediate-early protein.
Interferon Regulatory Factor 3 definition: IRF3 encodes interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. (from LocusLink)
brain regulatory center definition: collection of neurons in the central nervous system concerned with performance of a particular regulatory function.
Interferon Regulatory Factor-7 definition: An interferon regulatory factor that is induced by INTERFERONS as well as LMP-1 protein from EPSTEIN-BARR VIRUS. IRF-7 undergoes PHOSPHORYLATION prior to nuclear translocation and it activates GENETIC TRANSCRIPTION of multiple interferon GENES.
Apoptosis Inducing Factor definition: A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. It translocates to the CELL NUCLEUS and binds DNA to stimulate CASPASE-independent CHROMATIN condensation.
IRF4 Gene definition: This gene is involved in the regulation of B-cell differentiation and proliferation. It also plays a role in mediating the proliferation of mitogen-stimulated T cells.
Regulatory Protein definition: Encoded by Regulatory Genes, Regulatory Proteins regulate or circumscribe the activity of many cellular functions.
cytoskeletal regulatory protein binding definition: Interacting selectively with any protein involved in modulating the reorganization of the cytoskeleton. [GOC:go_curators, PMID:15163540]
IRF2 Gene definition: This gene is involved in the repression of IRF1-activated transcription. It also plays a role in the transcriptional activation of target genes.
IRF3 Gene definition: This gene plays a role in the transcriptional activation of target genes.
IRF1 Gene definition: This gene plays a role in the transcriptional activation of target genes. It is also involved in promoting apoptosis.
GCLM Gene definition: This gene is involved in the detoxification of endogenous reactive oxygen species. It also plays a role in drug and xenobiotic metabolism.
Interferon Regulatory Factor 6 definition: Interferon regulatory factor 6 (467 aa, ~53 kDa) is encoded by the human IRF6 gene. This protein plays a role in the regulation of transcription.
IRF6 Gene definition: This gene plays a role in transcriptional regulation and the development of the palate.
NR2F2 Gene definition: This gene is involved in transcriptional regulation.
Interferon Regulatory Factor 2 definition: Encoded by human IRF2 Gene (IRF Family), transcription factor Interferon Regulatory Factor 2 competitively inhibits IRF1-transcriptional activation of interferons alpha and beta, and perhaps other IRF1-activated genes. IRF2 also functions as a transcriptional activator of histone H4. (NCI)
Interferon Regulatory Factor-3 definition: An interferon regulatory factor that is expressed constitutively and undergoes POST-TRANSLATIONAL MODIFICATION following viral infection. PHOSPHORYLATION of IRF-3 causes the protein to be translocated from the CYTOPLASM to CELL NUCLEUS where it binds DNA, and activates transcription.
CDC25 and CHK1 Regulatory Pathway definition: Cdc25 is a protein phosphatase responsible for dephosphorylating and activating cdc2, a crucial step in regulating the entry of all eukaryotic cells into the M-phase of the cell cycle. Cdc25 is phosphorylated throughout interphase but not in mitosis. The primary site for phosphorylation of cdc25 is Ser216. Phosphorylated cdc25 binds to members of the 14-3-3 family of proteins which prevents its activation of cdc2. Chk1, a protein kinase involved in the DNA damage checkpoint response in fission yeast, has been shown to phosphorylate cdc25 at Ser216 in vitro. (BioCarta)
Regulatory Affairs definition: The business of a regulatory agency
Regulatory Pathway definition: An elaboration of the known or inferred interactions controlling the expression of a product.
Recombinant Pleiotrophin definition: A recombinant form of the heparin-binding cytokine pleiotrophin. Developmentally regulated, pleiotrophin functions as a growth factor during embryogenesis and the neonatal period, contributing to trophoblast formation, organ development, bone formation, and early brain development by inducing the differentiation and proliferation of neuronal tissue. Expressed in certain tumor cell types, this agent may stimulate tumor cell growth, angiogenesis, and metastasis. (NCI04)
Interferon Regulatory Factor 1 definition: Encoded by human IRF1 Gene (IRF Family), transcription factor Interferon Regulatory Factor 1 activates transcription of interferon genes alpha and beta, as well as genes induced by interferons alpha, beta, and gamma. IRF1 also regulates apoptosis and tumor-suppression. (NCI)
regulatory requirement definition: Indicates that the decision to substitute or to not substitute was driven by a jurisdictional regulatory requirement mandating or prohibiting substitution.
Regulatory Elements, Transcriptional definition: Nucleotide sequences of a gene that are involved in the regulation of GENETIC TRANSCRIPTION.
Apoptosis Regulatory Proteins definition: A large group of proteins that control APOPTOSIS. This family of proteins includes many ONCOGENE PROTEINS as well as a wide variety of classes of INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS such as CASPASES.
ER proteasome regulatory particle definition: The regulatory subcomplex of a proteasome located in the endoplasmic reticulum of a cell. [GOC:mah]
cytosolic proteasome regulatory particle definition: A multisubunit complex located in the cytosol of a cell, which caps one or both ends of the proteasome core complex. This complex recognizes, unfolds ubiquitinated proteins and translocates them to the proteasome core complex. [GOC:mah, GOC:mtg_sensu, GOC:proteasome]
Regulator definition: Something that controls the rate or manner in which a process progresses or a product is formed.
Regulatory Coordinator definition: A person that is responsible for ensuring compliance with government regulations and interacts with the regulatory agencies regarding toxicity, protocol administration, and drug approval procedures.
Gene Regulatory Networks definition: Interacting DNA-encoded regulatory subsystems in the GENOME that coordinate input from activator and repressor TRANSCRIPTION FACTORS during development, cell differentiation, or in response to environmental cues. The networks function to ultimately specify expression of particular sets of GENES for specific conditions, times, or locations.
Regulatory Application definition: A collection of submissions related to a particular regulated product that are grouped together for regulatory purposes and can be referenced in making one or more regulatory decisions.
Regulatory Assessment definition: A regulatory action or inaction undertaken by the regulatory authority as a result of a submission analysis and evaluation.
Regulatory Submission definition: An assembly of one or more regulatory submission units supporting a specific regulatory purpose or decision. In most cases, the compilation of the submission units is utilized in the assessment of a regulated medical product quality, safety and/or effectiveness.
régulateur definition: Agent d'une compagnie aérienne ou d'une société d'assistance chargé de l'affectation et du suivi des aéronefs en fonction des programmes d'exploitation.
régulateur definition: Personne chargée de répartir les missions des équipes d'intervention en fonction des demandes (appels de particuliers, demandes de renfort d'équipes en intervention…).