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Definition
 
enEnglish
Diuretics, Thiazide definition: Diuretics characterized as analogs of 1,2,4-benzothiadiazine-1,1-dioxide. All have a common mechanism of action and differ primarily in the dose required to produce a given effect. They act directly on the kidney to increase the excretion of sodium chloride and water and also increase excretion of potassium ions.
Macular Degeneration definition: Degenerative changes in the RETINA usually of older adults which results in a loss of vision in the center of the visual field (the MACULA LUTEA) because of damage to the retina. It occurs in dry and wet forms.
macular degeneration definition: deterioration of the macula lutea in the retina; may be inherited, drug induced, or due to aging; leads to a severe loss of central vision while peripheral vision is retained.
Presbycusis definition: Gradual bilateral hearing loss associated with aging that is due to progressive degeneration of cochlear structures and central auditory pathways. Hearing loss usually begins with the high frequencies then progresses to sounds of middle and low frequencies.
presbycusis definition: progressive bilateral loss of hearing that occurs in the aged.
Relationship definition: A state of connectedness between people, objects, or events; to be associated or connected with something.
Actin-Related Protein 2 definition: A PROFILIN binding domain protein that is part of the Arp2-3 complex. It is related in sequence and structure to ACTIN and binds ATP.
Actin-Related Protein 3 definition: A component of the Arp2-3 complex that is related in sequence and structure to ACTIN and that binds ATP. It is expressed at higher levels than ARP2 PROTEIN and does not contain a PROFILIN binding domain.
ABL2 Gene definition: This gene plays a role in signal transduction.
SWP59 definition: A component of the SWI/SNF global transcription activator complex and the RSC chromatin remodeling complex, SWP59 assists gene-specific activators through nucleosome/chromatin remodeling. The SWI/SNF complex is required for induced expression of many genes and alters chromatin structure to facilitate binding of gene-specific dedicated transcription factors. Actin-related SWP59 is a non-specific DNA-binding RNA polymerase II transcription factor ATPase. (from SGD S0004636 and NCI)
SWP61 definition: A component of the SWI/SNF global transcription activator complex and the RSC chromatin remodeling complex, SWP61 assists gene-specific activators through nucleosome/chromatin remodeling. The SWI/SNF complex is required for induced expression of many genes and alters chromatin structure to facilitate binding of gene-specific dedicated transcription factors. Actin-related SWP61 is a non-specific DNA-binding RNA polymerase II transcription factor. (from SGD S0006238 and NCI)
HIV related definition: HIV and AIDS related item
related definition:

An action taken with respect to a subject Entity by a regulatory or authoritative body with supervisory capacity over that entity. The action is taken in response to behavior by the subject Entity that body finds to be undesirable.

Suspension, license restrictions, monetary fine, letter of reprimand, mandated training, mandated supervision, etc.Examples:

work related definition:

A person becomes eligible for insurance or a program because of a work related health condition or injury.

Example: A person is a claimant under the U.S. Black Lung Program.

Definitely Related to Intervention definition: A characteristic used to qualify the adverse event as certainly related to the medical intervention. According to WHO causality assessment criteria of suspected adverse reactions it is applicable to a clinical event, including laboratory test abnormality, occurring in a plausible time relationship to medical intervention, and which cannot be explained by concurrent disease or other interventions. The response to withdrawal of the medical product (dechallenge) should be clinically plausible. The event must be definitive pharmacologically or phenomenologically, using a satisfactory rechallenge procedure if necessary.
Possibly Related to Intervention definition: A characteristic indicating that an adverse event may be related to the medical intervention. According to WHO causality assessment criteria of suspected adverse reactions it is applicable to a clinical event, including laboratory test abnormality, with a reasonable time sequence to administration of the drug, but which could also be explained by concurrent disease or other drugs or chemicals. Information on drug withdrawal may be lacking or unclear.
ABL2 wt Allele definition: Human ABL2 wild-type allele is located within 1q24-q25 and is approximately 126 kb in length. This allele, which encodes tyrosine-protein kinase ABL2 protein, is involved in signal transduction. The ABL2 gene is translocated in acute myelogenous leukemia.
Probably Related to Intervention definition: A characteristic used to qualify the adverse event as likely related to the medical intervention. According to WHO causality assessment criteria of suspected adverse reactions it is applicable to a clinical event, including laboratory test abnormality, with a reasonable time sequence to the medical intervention, unlikely to be attributed to concurrent disease or other medical interventions, and which follows a clinically reasonable response on withdrawal (dechallenge). Rechallenge information is not required to fulfill this definition.
Unlikely Related to Intervention definition: A characteristic used to qualify the adverse event as unlikely related to the medical intervention. According to WHO causality assessment criteria of suspected adverse reactions it is applicable to a clinical event, including laboratory test abnormality, with a temporal relationship to the medical intervention which makes a causal relationship improbable, and in which other interventions or underlying disease provide plausible explanations.
ALPHA BLOCKERS/RELATED definition: ALL SINGLE AGENT ALPHA BLOCKERS ARE LISTED IN THIS CATEGORY.INCLUDES BOTH PERIPHERAL AND CENTRAL
BETA BLOCKERS/RELATED definition: THIS CLASSIFICATION WILL INCLUDE SINGLE AGENT BETA BLOCKERS ANDALPHA-BETA BLOCKERS. SINGLE AGENTS ONLY. COMBINATIONS WILL BEINCLUDED IN CA400 ANTIHYPERTENSIVES,COMBINATIONS.
Nuclear Receptor Subfamily 4, Group A, Member 2 definition: An orphan nuclear receptor that is found at high levels in BRAIN tissue. The protein is believed to play a role in development and maintenance of NEURONS, particularly dopaminergic neurons.
alcohol-related definition: [1] alkoholbedingt
 
 
deGerman
verwandt definition: [1] genealogisch zusammengehörig; von gleicher Abstammung [2] gleich, ähnlich
ophthalmisch definition: [1] Anatomie: zum Auge gehörend, das Auge betreffend
 
frFrench
parent definition: Le père et la mère, collectivement (c’est la signification étymologique et propre).
parent definition: Le père ou la mère d’une personne, d’un enfant.
parent definition: Ceux de qui on descend.
parent definition: Membre de la même famille, de la parentèle. Dans cette acception, il s'utilise aussi au féminin.