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Definition
 
enEnglish
Required Organ Donation Request definition: An organ procurement policy based on the requirement that health personnel routinely make inquiry of family members about the possibility of removing organs from a patient who has been declared legally dead.
Not Applicable definition: Determination of a value is not relevant in the current context.
NOT APPLICABLE definition: Determination of a value is not relevant in the current context. (NCI)
Cofactor Required for Sp1 Transcriptional Activation Subunit 2 definition: Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. A multisubunit cofactor, CRSP (cofactor required for SP1 activation), which, along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD. Nine polypeptides have been identified as CRSP subunits. The CRSP2 gene at Xp11.4-p11.2 encodes a 150-kD protein that is subunit 2 of the CRSP complex. This CRSP2 protein is required for Sp1 mediated transcriptional activation with TAF(II)s. CRSP2 contains a cytochrome C family heme-binding motif and a bipartite nuclear localization signal. (from OMIM 300182, LocusLink 9282)
Cofactor Required for Sp1 Transcriptional Activation Subunit 3 definition: Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. A multisubunit cofactor, CRSP (cofactor required for SP1 activation) along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD. Nine polypeptides have been identified as CRSP subunits. The CRSP3 gene encodes this 130-kD protein that is subunit 3 of the CRSP complex. The CRSP3 protein is required for Sp1 mediated transcriptional activation with TAF(II)s. (from OMIM 605042, LocusLink 9439)
Cofactor Required for Sp1 Transcriptional Activation Subunit 4 definition: Encoded by human CRSP4 Gene, Cofactor Required for Sp1 Transcriptional Activation Subunit 4 is 100-kD protein of the CRSP (Cofactor Required for SP1 activation) complex, which, along with TFIID, is required for efficient activation of gene transcription by SP1, a transcription factor that recognizes enhancer sites in target DNA. Many CRSP complex proteins are also components of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins that interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. (NCI)
Cofactor Required for Sp1 Transcriptional Activation Subunit 6 definition: Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. A multisubunit cofactor, CRSP (cofactor required for SP1 activation), which, along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD. Nine polypeptides have been identified as CRSP subunits. The CRSP6 gene at 11q14 encodes this 80-kD protein that is subunit 6 of the CRSP complex. This CRSP6 protein is required for Sp1 mediated transcriptional activation with TAF(II)s.
Cofactor Required for Sp1 Transcriptional Activation Subunit 7 definition: Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. A multisubunit cofactor, CRSP (cofactor required for SP1 activation), which, along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD. Nine polypeptides have been identified as CRSP subunits. The CRSP6 gene at 11q14 encodes this 80-kD protein that is subunit 6 of the CRSP complex. This CRSP6 protein is required for Sp1 mediated transcriptional activation with TAF(II)s.
Cofactor Required for Sp1 Transcriptional Activation Subunit 8 definition: Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. A multisubunit cofactor, CRSP (cofactor required for SP1 activation), which, along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD. Nine polypeptides have been identified as CRSP subunits. The CRSP8 gene encodes this 34-kD protein that is subunit 8 of the CRSP complex. The CRSP8 protein is required for Sp1-mediated transcriptional activation with TAF(II)s. (from OMIM 605044, LocusLink 9442)
Cofactor Required for Sp1 Transcriptional Activation Subunit 9 definition: Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. A multisubunit cofactor, CRSP (cofactor required for SP1 activation), along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD and 9 polypeptides have been identified as CRSP subunits. The CRSP9 gene encodes this 33-kD protein that is subunit 9of the CRSP complex. The CRSP9 protein is required with the TAF(II)s for Sp1-mediated transcriptional activation. (from OMIM 605045, LocusLink 9443)
MED14 Gene definition: This gene plays a role in activation of Sp1 transcription. It is also involved in vitamin D and thyroid hormone binding.
MED23 Gene definition: This gene is involved in activation of Sp1 transcription. It also plays a role in suppression of metastasis.
MED17 Gene definition: This gene is involved in coactivation of Sp1 transcription. It also plays a role in vitamin D and thyroid hormone binding.
MED26 Gene definition: This gene plays a role in the activation of Sp1 transcription.
MED27 Gene definition: This gene is involved in the transcriptional activation of Sp1.
MED7 Gene definition: This gene plays a role in coactivation of Sp1 transcription.
Cofactor Required for SP1 Activation definition: A protein complex, which, along with TFIID, is required for efficient transcriptional activation by SP1.
MED1 Gene definition: This gene plays a role in the transcriptional activation of target genes. It is involved in embryonic fibroblast differentiation and normal development of vital organs.
Requirement definition: Something that is necessary; condition, something that is obligatory.
Not required definition: The message element may be populated or used by one system sponsor (or profile), but not by another. Each system sponsor or profile is required to state the ability to accept or send the message element as part of a conformance claim.
required definition: A signature for the service is required of this actor.
Required may be empty definition: Pursuant to a profile or vendor conformance claim, the message element must appear every time the message is communicated, but the value may be communicated as null.
Missing required element. definition: A required message element is missing.
referral not required definition: Rules of practice do not require a physician's referral for the provider to perform a billable service.
Required definition: The message element must appear every time the message is communicated, but the value may be communicated as null.
Required - V2.x definition: The message element must appear every time the message is communicated and its value must not be null. This condition is subject to the rules of multiplicity and conditionality. If a non-null default value is defined for the element, a null value may be communicated.
Mandatory definition: The message element must appear every time the message is communicated and its value must not be null. This condition is subject to the rules of multiplicity and conditionality. If a non-null default value is defined for the element, a null value may be communicated.
Required attribute missing definition: A required attribute is missing in a class.
Required association missing definition: Required association missing in message; or the sequence of the classes is different than required by the standard or one of the conformance profiles identified in the message.
Intervention Required definition: A patient condition when action or ministration whose purpose is to improve health or to alter the course of a disease is considered essential and mandatory in order to prevent permanent impairment or damage.
Endosomal Sorting Complexes Required for Transport definition: A set of protein subcomplexes involved in PROTEIN SORTING of UBIQUITINATED PROTEINS into intraluminal vesicles of MULTIVESICULAR BODIES and in membrane scission during formation of intraluminal vesicles, during the final step of CYTOKINESIS, and during the budding of enveloped viruses. The ESCRT machinery is comprised of the protein products of Class E vacuolar protein sorting genes.
Recommended Intake definition: A property indicating that the Food and Nutrition Board of the National Academy of Science has established an average daily intake for this nutrient that is sufficient to meet the nutritional requirements of most individuals in the general U.S. population.
 
 
frFrench
requis definition: Personne contrainte à effectuer une tâche par les autorités lors d’une guerre.