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Antibody Formation definition: The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.
antibody formation definition: synthesis of antibodies in response to B-cell activation by antigens; includes genetic regulation, recombination, all aspects of gene expression of the antibodies as well as the proliferation and differentiation of the B lymphocytes into plasma cells or memory cells.
immunoglobulin production definition: The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
Evoked Potentials, Auditory definition: The electric response evoked in the CEREBRAL CORTEX by ACOUSTIC STIMULATION or stimulation of the AUDITORY PATHWAYS.
Evoked Potentials, Visual definition: The electric response evoked in the cerebral cortex by visual stimulation or stimulation of the visual pathways.
Galvanic Skin Response definition: A change in electrical resistance of the skin, occurring in emotion and in certain other conditions.
galvanic skin response definition: change in electrical resistance of the skin, occurring during changing emotional states and in certain other conditions.
Individuality definition: Those psychological characteristics which differentiate individuals from one another.
Reflex, Babinski definition: An abnormal reflex consisting of dorsiflexion of the great toe and abduction of the other toes in response to cutaneous stimulation of the plantar surface of the foot.
Satiety Response definition: Behavioral response associated with the achieving of gratification.
SOS Response (Genetics) definition: An error-prone mechanism or set of functions for repairing damaged microbial DNA. SOS functions (a concept reputedly derived from the SOS of the international distress signal) are involved in DNA repair and mutagenesis, in cell division inhibition, in recovery of normal physiological conditions after DNA repair, and possibly in cell death when DNA damage is extensive.
SOS response definition: An error-prone process for repairing damaged microbial DNA. [GOC:jl, http://cancerweb.ncl.ac.uk/]
SOS Function definition: A series of erroneous bacterial processes that are utilized to maintain the integrity of DNA during cellular metabolism. These functions are involved in maintenance activities such as DNA repair, but they are also involved in apoptosis and mitotic inhibition.
Evoked Potentials, Auditory, Brain Stem definition: Electrical waves in the CEREBRAL CORTEX generated by BRAIN STEM structures in response to auditory click stimuli. These are found to be abnormal in many patients with CEREBELLOPONTINE ANGLE lesions, MULTIPLE SCLEROSIS, or other DEMYELINATING DISEASES.
Dysfunctional Grieving definition: Prolonged feeling of great sorrow.
Heat-Shock Response definition: A constellation of responses that occur when an organism is exposed to excessive heat and other environmental stressors. Responses include synthesis of some proteins, repression of other proteins, and expression of new proteins. (From Segen, Dictionary of Modern Medicine, 1992)
Heat-Shock Response definition: A constellation of responses that occur when an organism is exposed to excessive heat and other environmental stresses. Responses include synthesis of some proteins, repression of other proteins, and expression of new proteins. (From Segen, Dictionary of Modern Medicine, 1992)
mucosal immune response definition: An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract. [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
Graft vs Leukemia Effect definition: Immunological rejection of leukemia cells following bone marrow transplantation.
Graft-vs-Leukemia Effect definition: an advantageous side-effect of a graft-vs-host reaction in which a leukemia patient is first irradiated to kill residual leukemic cells and is then given a bone marrow graft to replenish the immune system. If cytotoxic T cells are not depleted from the bone marrow graft, these alloreactive T cells can attack the host's cells (graft-vs-host reaction) but can also attack the host's residual leukemic cells, thereby assisting in preventing recurrence of disease.
Graft vs Tumor Effect definition: Immunological rejection of tumor tissue/cells following bone marrow transplantation.
response to unfolded protein definition: A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus. [GOC:jl]
Unfolded Protein Response definition: A cellular response to environmental insults that cause disruptions in PROTEIN FOLDING and/or accumulation of defectively folded protein in the ENDOPLASMIC RETICULUM. It consists of a group of regulatory cascades that are triggered as a response to altered levels of calcium and/or the redox state of the endoplasmic reticulum. Persistent activation of the unfolded protein response leads to the induction of APOPTOSIS.
Immobility Response, Tonic definition: An induced response to threatening stimuli characterized by complete loss of muscle strength.
B-Cell Immune Response Pathway definition: APRIL and BAFF (also called TALL-I and BLyS) are TNF family members that act as ligands for the BCMA and TACI receptors. Both APRIL and BAFF bind to both the BCMA and TACI receptors to activate the humoral immune response, stimulating B cell immunoglobulin production and proliferation. BAFF is found as a membrane bound form in T cells and a soluble form that is released from the cell to stimulate B cell proliferation and differentiation. As members of the TNF receptor gene family, BCMA and TACI interact with TRAF family members to transduce signals downstream to NF-kappaB activation and MAP kinase pathways. Abnormally active BAFF or APRIL signaling may play a role in autoimmune disorders such as lupus. (BioCarta)
Sumoylation in Modulation of CtBP-Dependent Gene Response Pathway definition: Covalent attachment of one eukaryotic protein to another is a prominent posttranslational modification and Ubiquitin is the most familiar of the protein modifiers. Recently a new group of ubiquitin-like (Ubl) proteins have come to light. One of the most intriguing of them is SUMO (small ubiquitin-like modifier, ~12kDa) also known as Sentrin. SUMO family has been described in vertebrates: SUMO-1 and the closest homologs SUMO-2 and SUMO-3. SUMO have been shown to bind and regulate mammalian SP-RINGs (such as Mdm2, PIAS and PML), RanGAP1, RanBP2, p53, p73, HIPK2, TEL, c-Jun, CtBP, Fas, Daxx, TNFRI, Topo-I, Topo-II, WRN, Sp100, IkB-alpha, Androgen receptor (AR), GLUT1/4, Drosophila Ttk69, Dorsal, CaMK, yeast Septins, and viral CMV-IE1/2, EBV-BZLF1, HPV/BPV-E1. In the case of the transcription co-repressor CtBP, which can be recruited to the target promoter via interaction with a conserved PxDLS motif in the interacting repressor, CtBP SUMOylation profoundly affected its subcellular localization. SUMOylation occurred at a single Lys residue, Lys428, of CtBP1. Mutating Lys428 into Arg (K428R) shifted CtBP1 from the nucleus to the cytoplasm, while it had little effect on its interaction with the PxDLS motif. The K428R mutation also abolished the ability of CtBP1 to repress the E-cadherin promoter activity. Consistent with the known inhibitory effect of nNOS on the nuclear accumulation of CtBP1, PDZ domain of nNOS inhibits the SUMOylation of CtBP1. The current data indicates that SUMOylation can regulate CtBP1-dependent transcriptional repression. (BioCarta)
The patient demonstrates knowledge of the expected responses to the operative or invasive procedure. definition: The patient/family members communicate an understanding of the operative or other invasive procedure and effects they can expect. This is evidenced by their consent for the procedure and description of the perioperative sequence of events and outcomes.