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osteopontin definition: bone-associated phosphorylated cell attachment glycoprotein; may be involved in bone metabolism; also found in chondrocytes, kidney, intestine, ovary, and the inner ear.
Osteopontin definition: Human osteopontin ( 314 aa, ~32,000 kD) is a bone phosphoprotein that interacts with the extracellular matrix. Osteopontin exists in 4 isoforms, and is secreted by secretory phase ductal epithelium. Implicated in the pathogenesis of several cancers. 2005
Osteopontin definition: A negatively-charged extracellular matrix protein that plays a role in the regulation of BONE metabolism and a variety of other biological functions. Cell signaling by osteopontin may occur through a cell adhesion sequence that recognizes INTEGRIN ALPHA-V BETA-3.
Ephrin-A1 definition: An ephrin that was originally identified as the product of an early response gene induced by TUMOR NECROSIS FACTORS. It is linked to the CELL MEMBRANE via a GLYCOINOSITOL PHOSPHOLIPID MEMBRANE ANCHOR and binds EPHA2 RECEPTOR with high affinity. During embryogenesis high levels of ephrin-A1 are expressed in LUNG; KIDNEY; SALIVARY GLANDS; and INTESTINE.
Melanocyte Lineage-Specific Antigen gp100 definition: Expressed in melanocytes and melanomas by human SILV Gene (PMEL17/NMB Family), 661-aa 70-kDa (precursor) Melanocyte Lineage-Specific Antigen gp100is a probable type I membrane protein containing a putative leader sequence, a potential membrane anchor segment, 5 potential N-glycosylation sites, high levels of serine and threonine, a PKD domain, and amino acid similarity to tyrosinase and CAS2 protein. PMEL17 cross reacts with antityrosinase antibodies and expression correlates with melanin content. The soluble ME20-S form is a probable proteolytic cleavage product. CD8 T lymphocytes recognize a noncontiguous spliced nonameric sequence of gp100 on melanoma cells. Splicing appears to occur by transpeptidation involving an acyl-enzyme intermediate. (NCI)
Follistatin-Like 3 Glycoprotein definition: Secreted Follistatin-Like 3 Glycoprotein binds to activin and is highly homologous to follistatin, an activin ligand. It is a member of the follistatin-module protein family, which is composed of extracellular matrix-associated glycoproteins thought to act in a paracrine manner to bind morphogens or growth/differentiation factors and regulate their activity during development. In addition to the t(11;19) translocation in a case of B-cell chronic lymphocytic leukemia from which FSTL3 was isolated, rearrangement of the FSTL3 gene was also observed in a case of B-cell non-Hodgkin lymphoma and in a case of B-cell mantle zone lymphoma, suggesting that FSTL3 may be involved in the leukemogenesis process.
Follistatin-Like Protein 3 definition: A secreted glycoprotein of approximately 28 kD, encoded by the FLRG or FSTL3 gene.
Beta-Microseminoprotein definition: Encoded by human MSMB Gene (Ig Binding Factor Family, Beta-Microseminoprotein Family), 12.8 kD (precursor) secreted Beta-Microseminoprotein (isoforms PSP94 and PSP57) is expressed in prostate, liver, kidney, breast, penis, pancreas, esophagus, stomach, duodenum, colon, trachea, lung, salivary glands, and fallopian tube. PSP94 is also expressed in lung and breast; PSP57 is found in kidney and bladder. The 94-amino acid seminal protein is derived from a pre-polypeptide of 114 amino acids. Specific receptors are found on spermatozoa and in the prostate. The protein may have inhibin-like activity; it may act as an autocrine paracrine factor in uterine, breast, and other female reproductive tissues and may inhibit pituitary secretion of FSH. (from Swiss-Prot, OMIM, and NCI)
Secreted and Transmembrane 1 Protein definition: Widely expressed (highest in myeloid leukocytes) by human SECTM1 Gene, 248-aa 27-kDa (precursor) Secreted and Transmembrane 1 Protein is an integral type 1a transmembrane protein (extracellular N terminus and cleaved signal peptide) found in the Golgi apparatus and thought to be involved in hematopoietic and/or immune system processes. K12 interacts with CD7 and an approximately 20-kD soluble form is secreted by cells. (NCI)
WNT2 Gene definition: This gene plays a role in signal transduction and intercellular communication. It is involved in the mediation of cell behavior and fate during vertebrate development.
Secreted Frizzled-Related Protein 4 definition: Encoded by human SFRP4 Gene (SFRP Family), Secreted Frizzled-Related Protein 4 is a soluble modulator of WNT signaling that contains an N-terminal signal peptide, no transmembrane domain, a hydrophilic C terminus, and a Cys-rich domain homologous to the putative WNT-binding site of Frizzled proteins. Involved in cytoskeletal regulation, apoptosis, and proliferation, WNT-mediated simulation of 'Frizzled' receptors can activate beta-catenin, MAPK kinase, and G protein pathways. Bound to WNTs or frizzled receptors, secreted frizzled-related proteins antagonize WNT/frizzled pathways. SFRP4 may inhibit WNT8-mediated development of secondary axes. (NCI)
Resistin definition: A 12-kDa cysteine-rich polypeptide hormone secreted by FAT CELLS in the ADIPOSE TISSUE. It is the founding member of the resistin-like molecule (RELM) hormone family. Resistin suppresses the ability of INSULIN to stimulate cellular GLUCOSE uptake.
secreted phospholipase A2 activity definition: OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion. [EC:]
calcium-dependent secreted phospholipase A2 activity definition: OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion. [EC:]
secretion definition: The controlled release of a substance by a cell, a group of cells, or a tissue. [GOC:ai]
secretion by cell definition: The controlled release of a substance by a cell. [GOC:mah]
Cellular Secretion definition: Production by a cell or aggregation of cells (a gland) of a physiologically active substance and its movement out of the cell or organ in which it is formed. Discharge across the cell membrane, into the intracellular space or ducts, of endogenous substances resulting from the activity of intact cells of glands, tissues, or organs.
AGR2 Protein definition: Encoded by human AGR2 Gene, soluble Anterior Gradient 2 Homologue Protein is 47% identical to the cement gland anterior gradient protein (Xenopus laevis) and 91% identical to the mouse protein. Strongest expression is seen in the lung; weaker expression in the pancreas and other tissues. Strong expression is also detected in trachea, stomach, colon, prostate, and small intestine. (from OMIM, and NCI)
CCL1 Gene definition: This gene is involved in the regulation and modulation of inflammatory processes.
FSTL3 Gene definition: This gene plays a role in a variety of processes including transcription.
SECTM1 Gene definition: This gene plays a role in hematopoetic and immune system processes.
SFRP4 Gene definition: This gene plays a role in signal transduction, apoptosis and cell proliferation.
Tumor-Secreted Protein definition: Proteins or protein fragments secreted from, or shed by, tumor cells.
Small Inducible Cytokine A1 definition: A CCR8-ligand, the inflammatory CXC cytokine I-309 is a small inducible chemotactic factor produced by activated T-lymphocytes, mast cells, and monocytes that appears to also promote angiogenesis. (from OMIM 182281 and NCI)
WNT1 Inducible Signaling Pathway Protein 1 definition: Associated with cell survival and expressed in fibroblasts (high), heart, kidney, lung, pancreas, placenta, ovary, small intestine, and spleen by human WISP1 Gene (WISP/CCN/CTGF Family), 367-aa 40-kDa (precursor) and 280-aa isoforms of secreted WNT1 Inducible Signaling Pathway Protein 1 contain 4 conserved Cys-rich domains: a IGFBP domain, a VWFC domain, a TSP type-1 domain, and a CTCK domain. WISP1 up-regulates anti-apoptotic BCL-X(L) protein and attenuates p53-mediated apoptosis induced by DNA damage through activation of AKT kinase. WISP1 binds to, and may prevent the anti-proliferation activity of, decorin and biglycan, small leucine-rich connective tissue extracellular matrix proteoglycans. WISP1 may act as a downstream regulator in the WNT/Frizzled signaling pathway. (NCI)
SECTM1 wt Allele definition: Human SECTM1 wild-type allele is located within 17q25 and is approximately 13 kb in length. This allele, which encodes secreted and transmembrane protein 1, is involved in hematopoietic and immune system processes.
PLA2G2A wt Allele definition: Human PLA2G2A wild-type allele is located within 1p35 and is approximately 5 kb in length. This allele, which encodes phospholipase A2, membrane associated protein, is involved in the regulation of phospholipid metabolism in biomembranes.
Phospholipases A2, Secretory definition: A subcategory of phospholipases A2 that are secreted from cells. They are 14 kDa proteins containing multiple disulfide-bonds and access their substrate via an interfacial binding site that interacts with phospholipid membranes. In addition specific PHOSPHOLIPASE A2 RECEPTORS can bind to and internalize the enzymes.
FSTL3 wt Allele definition: Human FSTL3 wild-type allele is located within 19p13 and is approximately 7 kb in length. This allele, which encodes follistatin-related protein 3, plays a role in transcription, cell signaling and leukemogenesis.
Matrix Metalloproteinases, Secreted definition: A subclass of matrix metalloproteinases that are secreted into the pericellular space.
interaction with host via secreted substance definition: An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]
interaction with symbiont via secreted substance definition: An interaction with the symbiont organism mediated by a substance secreted by the other (host) organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. [GOC:mtg_pamgo_17jul06]
detection of cell density by secreted molecule definition: The series of events in which information about the density of cells in a population is received by the detection of a secreted molecule and is converted into a molecular signal. [GOC:dph]