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Amino Acid Sequence definition: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
protein sequence definition: order of amino acids as they occur in a polypeptide chain.
amino acid sequence definition: The arrangement of amino acids in a protein. Proteins can be made from 20 different kinds of amino acids, and the structure and function of each type of protein are determined by the kinds of amino acids used to make it and how they are arranged.
Amino Acid Sequence definition: The sequence of amino acids along a polypeptide chain.
AT Rich Sequence definition: A nucleic acid sequence that contains an above average number of ADENINE and THYMINE bases.
Base Sequence definition: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
nucleic acid sequence definition: order of purines and pyrimidines in nucleic acids and polynucleotides.
Nucleotide Sequence definition: The sequence of nucleotide residues along an RNA or DNA chain.
Carbohydrate Sequence definition: The sequence of carbohydrates within POLYSACCHARIDES; GLYCOPROTEINS; and GLYCOLIPIDS.
carbohydrate sequence definition: sequence of carbohydrates within polysaccharides, glycoproteins, and glycolipids.
Conserved Sequence definition: A sequence of amino acids in a polypeptide or of nucleotides in DNA or RNA that is similar across multiple species. A known set of conserved sequences is represented by a CONSENSUS SEQUENCE. AMINO ACID MOTIFS are often composed of conserved sequences.
DiGeorge's syndrome definition: congenital syndrome with the absence of the thymus and parathyroids causing impairment of cellular immunity; immunoglobulin levels are normal.
DiGeorge Syndrome definition: Congenital syndrome characterized by a spectrum of malformations including the absence of the THYMUS and PARATHYROID GLANDS resulting in T-cell immunodeficiency and HYPOCALCEMIA. Other features include defects in the outflow tract of the HEART and craniofacial anomalies (velocardiofacial syndrome). Most cases result from a deletion of chromosome 22q11.2 or mutation in the TBX1 gene.
DiGeorge Syndrome definition: A congenital anomaly characterized by immunodeficiency, abnormal facies, congenital heart disease, hypocalcemia, and increased susceptibility to infections. Pathologic characteristics include conotruncal abnormalities and absence or hypoplasia of thymus and parathyroid glands. DiGeorge syndrome is associated with abnormalities of chromosome 22. Also known as DiGeorge anomaly.
branchial arch syndrome definition: Branchial arch defects with craniofacial abnormalities, hearing loss, short stature, and learning difficulty.
DiGeorge syndrome (DGS) definition: A developmental defect of derivatives of the third and fourth pharyngeal pouches, almost always associated with agenesis or hypoplasia of the thymus and parathyroid gland, characteristic facies with downslanting palpebral fissures and ocular and nasal anomalies, hypocalcemia, cardiovascular anomalies, immunodeficiency, and other variable abnormalities. Patients who survive infancy are usually mentally retarded. DiGeorge syndrome is considered by some researchers as a developmental field defect consisting of several casually distinct disorders, rather than a distinct syndromic entity. Conditions associated with the development of DiGeorge syndrome include diabetic embryopathy, fetal alcohol syndrome, and Zellweger syndrome. Major features of this syndrome have been designated by the Newcastle Upon Tyne Group CATCH 22 (Cardiac, Abnormal facies, Thymic hypoplasia, Cleft palate, and Hypocalcemia), the number 22 indicating deletion of the long arm of chromosome 22 (22q11).
genetic enhancer element definition: cis-acting DNA sequences which can increase transcription of genes; enhancers can usually function in either orientation and at various distances from a promoter.
Enhancer Elements, Genetic definition: Cis-acting DNA sequences which can increase transcription of genes. Enhancers can usually function in either orientation and at various distances from a promoter.
Introns definition: Sequences of DNA in the genes that are located between the EXONS. They are transcribed along with the exons but are removed from the primary gene transcript by RNA SPLICING to leave mature RNA. Some introns code for separate genes.
intron definition: noncoding intervening sequence in a gene; separates the coding sequences.
Intron definition: Non-coding, intervening sequences of DNA that are transcribed, but are removed from within the primary gene transcript and rapidly degraded during maturation of messenger RNA.
Pierre Robin Syndrome definition: An autosomal recessive disorder characterized by brachygnathia and cleft palate, often associated with glossoptosis, backward and upward displacement of the larynx, and angulation of the manubrium sterni. Cleft palate makes sucking and swallowing difficult, permitting easy access of fluids into the larynx. It may appear in several syndromes or as an isolated hypoplasia. (Dorland, 27th ed)
Poland Syndrome definition: A syndrome which is characterized by symbrachydactyly and aplasia of the sternal head of pectoralis major.
protein signal sequence definition: N-terminal, hydrophobic sequences which mediate the attachment of newly translated polypeptide chains to intracellular membranes; in some membrane proteins the signal peptide remains as a permanent anchor, while in secretory proteins it is cleaved.
Signal Peptide definition: The N-terminal sequence of a secreted protein that interacts with a signal recognition particle and is required for transport through the cell membrane.
Signal Peptides definition: Highly hydrophobic amino acid sequences of proteins that must cross through membranes to arrive at their functioning cellular location (such as secreted and membrane proteins). They are 15 to 60 amino acids long and reside at the amino-terminus (leader signal peptides) or internally. By binding to signal recognition particles, these sequences direct nascent protein-ribosome complexes to a membrane where the protein is inserted during translation. Signal peptides direct translational uptake of the protein by various membranes -endoplamic reticulum, mitochondrial, chloroplast, peroxisomal, etc. Leader signal sequences on non-membrane proteins are ultimately removed by specific peptidases.
Situs Inversus definition: A congenital abnormality in which organs in the THORAX and the ABDOMEN are opposite to their normal positions (situs solitus) due to lateral transposition. Normally the STOMACH and SPLEEN are on the left, LIVER on the right, the three-lobed right lung is on the right, and the two-lobed left lung on the left. Situs inversus has a familial pattern and has been associated with a number of genes related to microtubule-associated proteins.
heterotaxia syndrome definition: A laterization defect marked by asymmetric position of visceral organs usually occurring as a component of a wide variety of abnormalities. Transposition may be complete, with the heart, lungs and all abdominal organs reversed, or incomplete, manifesting itself as a simple reversal of the stomach or spleen. Associated malformations are variable and may include tetralogy of Fallot, transposition of great vessels, pulmonary valve stenosis, ventricular and atrial septal defects, asplenia-polysplenia. and other defects.
RGD Motif definition: A consensus tripeptide that is recognized by and for binding to proteins of the integrin family, including many cell adhesion molecules. The one-letter codes for arginine - glycine - aspartic acid. This motif can be found in proteins of the extracellular matrix and it is recognized by different members of the integrin family. The structure of the tenth type III module of fibronectin has shown that the RGD motif lies on a flexible loop.
Consensus Sequence definition: A theoretical representative nucleotide or amino acid sequence in which each nucleotide or amino acid is the one which occurs most frequently at that site in the different sequences which occur in nature. The phrase also refers to an actual sequence which approximates the theoretical consensus. A known CONSERVED SEQUENCE set is represented by a consensus sequence. Commonly observed supersecondary protein structures (AMINO ACID MOTIFS) are often formed by conserved sequences.
Consensus Sequence definition: A sequence pattern derived from the alignment of multiple sequences that represents the nucleotide or amino acid most likely to occur at each position in a sequence. (Drug Discovery & Development, www.dddmag.com glossary)
Open Reading Frames definition: A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).
open reading frame definition: sequences of structural genes devoid of termination codons and therefore continuously "readable" by RNA polymerase.
Coding Region definition: The sequences on a gene or messenger RNA that are translated into protein.
Open Reading Frame definition: A sequence of nucleotides in that contains no termination codons and so can potentially translate as a polypeptide chain.
Sequence Alignment definition: The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Repetitive Sequence definition: Nucleotide sequences present in multiple copies in the genome. There are several types of repeated sequences. Interspersed (or dispersed) DNA repeats (Interspersed Repetitive Sequences) are copies of transposable elements interspersed throughout the genome. Flanking (or terminal) repeats (Terminal Repeat Sequences) are sequences that are repeated on both ends of a sequence, for example, the long terminal repeats (LTRs) on retroviruses. Direct terminal repeats are in the same direction and inverted terminal repeats are opposite to each other in direction. Tandem repeats (Tandem Repeat Sequences) are repeated copies which lie adjacent to each other. These can also be direct or inverted. The ribosomal RNA and transfer RNA genes belong to the class of middle repetitive DNA.
DNA Sequence definition: The sequence of nucleotide residues along a DNA chain.
Sequence Deletion definition: Deletion of sequences of nucleic acids from the genetic material of an individual.
Sequence Homology definition: The degree of similarity between sequences. Studies of AMINO ACID SEQUENCE HOMOLOGY and NUCLEIC ACID SEQUENCE HOMOLOGY provide useful information about the genetic relatedness of genes, gene products, and species.
Sequence Analysis definition: A multistage process that includes the determination of a sequence (protein, carbohydrate, etc.), its fragmentation and analysis, and the interpretation of the resulting sequence information.
Sequence Analysis definition: The determination of the sequence of component residues in a macromolecule, e.g. amino acids in a protein or nucleotide bases in DNA/RNA or the computational analysis performed to determine the similarities between nonidentical proteins or molecules of DNA or RNA.
transposon/insertion element definition: endogenous DNA sequences able to be excised from one place and inserted at another place in the genome (transposons), or exogenous, usually viral sequences able to be inserted regardless of complementarity to endogenous genes.
Mobius Syndrome definition: A syndrome of congenital facial paralysis, frequently associated with abducens palsy and other congenital abnormalities including lingual palsy, clubfeet, brachial disorders, cognitive deficits, and pectoral muscle defects. Pathologic findings are variable and include brain stem nuclear aplasia, facial nerve aplasia, and facial muscle aplasia, consistent with a multifactorial etiology. (Adams et al., Principles of Neurology, 6th ed, p1020)
blepharophimosis-ptosis-epicanthus inversus (BPEI) syndrome (BPES) definition: Abnormal narrowing of the palpebral fissures with drooping and epicanthus inversus are the principal characteristics of this syndrome. Associated disorders may include mental retardation, ovarian and uterine atrophy with infertility, and lacrimal abnormalities. Type I occurs in females and is associated with infertility. Type II occurs in both males and females.
Goldenhar Syndrome definition: Mandibulofacial dysostosis with congenital eyelid dermoids.
oculo-auriculovertebral (OAV) dysplasia definition: A complex syndrome characterized mainly by aural, oral, and mandibular developmental anomalies which may vary from mild to severe and frequently involve one side of the body. Vertebral anomalies, epibulbar epidermoids, mental retardation, and numerous other anomalies are frequently associated. Orofacial anomalies differ from those in mandibulofacial dysostosis which are usually symmetrical. The presence of hypertelorism may indicate aneuploidy.
gene mutation definition: any detectable and heritable change in the genetic material that causes a change in the genotype and which is transmitted to daughter cells and to succeeding generations.
Gene Mutation definition: A gene mutation is an alteration in the nucleotide sequence of a gene, involving a single or multiple nucleotide substitution, deletion, insertion, or rearrangement that is perpetuated in subsequent divisions of the cell in which it occurs.
Sequence definition: A serial arrangement in which things follow in logical order or a recurrent pattern.
Composite Sequence definition: A collection of Reporter or CompositeSequence Design Elements, annotated through the association to BioSequence. (caMAGE)
Interval Scale definition: A scale that uses ordered numbers with a constant difference but with no natural zero and where difference makes sense but ratios do not.
Ordinal Scale definition: A scale that uses ordered numbers where the difference between successive designations may not be constant.
Ratio Scale definition: A scale that uses ordered numbers with a constant difference and which has a natural zero.
Sequence Logo definition: A graph of the data from a position weight matrix using the letters of the residues drawn in a size that corresponds to their likelihood in the sequence. It is an alternative representation of the CONSENSUS SEQUENCE, including more information, specifically, the information about the less frequently occurring residues as well as the most frequently occurring residues.
Sequence Inversion definition: The deletion and reinsertion of a segment of a nucleic acid sequence in the same place, but flipped in an opposite orientation.
sequence definition: Chaîne.
sequence definition: Séquence, succession, suite, enchaînement.
sequence definition: Série.
sequence definition: Suite.
Folge definition: [1] Ergebnis oder Wirkung einer Handlung oder eines Geschehens. [2] Reihe von aufeinanderfolgenden Dingen oder Ereignissen [3] Teil einer Serie, insbesondere bei Büchern, Zeitschriften und Fernsehserien [4] Mathematik: in ihrer Reihenfolge festgelegte Liste von Zahlen; genauer: eine Abbildung der natürlichen Zahlen auf eine andere Menge
Reihenfolge definition: [1] geregelte, ordnungsgemäße Aufeinanderfolge
Ablauf definition: [1] Allgemein: Prozess, Abfolge [2] Wasserablauf, eine Vorrichtung zum Ablaufen von Flüssigkeiten [3] Ein Verbindungsbauteil [4] Beendigung einer Zeitspanne, zu Ende gehen
Sequenz definition: [1] ein Folge von gleichartigen Dingen [2] Film: filmische Einheit, bei der die Abfolge der Ereignisse in Ort und/oder Zeit nicht durchgängig ist, aber in einem gedanklichen Zusammenhang stehen
roman-fleuve definition: Roman en plusieurs tomes (souvent plus d’une dizaine) dont les histoires se déroulent autour des mêmes personnages, et qui constitue un commentaire d’une société ou d’une époque.
série definition: Suite, succession.
série definition: Suite de grandeurs qui croissent ou décroissent suivant une certaine loi.
série definition: Divisions dans lesquelles on classe, on distribue des objets nombreux.
suite definition: Ce ou ceux qui suivent, ce ou ceux qui vont après.
suite definition: Ceux qui accompagnent quelqu’un pour lui faire honneur.
suite definition: Choses qui sont la continuation, le développement de choses du même ordre.
suite definition: Continuation, ce qui est ajouté à un ouvrage pour le continuer.
suite definition: Époque postérieure à celle dont on parle.
suite definition: Série, enchaînement, succession.
suite definition: Série de choses de même espèce, que l’on range selon l’ordre des temps ou des matières.
suite definition: Série de gravures d’un ouvrage tirées à part.
suite definition: Œuvre composée de plusieurs pièces successives.
suite definition: Certain nombre de personnes qui ont succédé les unes aux autres.
suite definition: Termes qui se succèdent suivant une loi précise.
suite definition: Ordre, liaison.
suite definition: Action de suivre le gibier.
suite definition: Possibilité de poursuite, de saisie.
rangée definition: Suite d'objet ou de personnes sur un même rang, sur une même file.
séquence definition: Suite ordonnée d’éléments.
séquence definition: Réunion de trois cartes au moins de la même couleur et dont les valeurs se suivent.
séquence definition: Série de plans continus qui forment une unité narrative.
séquence definition: Pièce en vers mesurés et rimés, que l’on chante aux messes solennelles après le graduel et l’alléluia.
enchainement definition: Action d’enchainer.
enchainement definition: Ensemble, réunion de choses qui forment une chaine.
enchainement definition: Liaison ou suite de plusieurs choses de même nature, de même qualité, ou de choses qui ont entre elles certains rapports.